Changes of the inflammatory activity and fibrosis in patients with alcoholic liver cirrhosis after autologoushematopoietic stem cell transplantation
G R Burganova , S R Abdulkhakov , A A Gumerova , I M Gazizov , T S Yylmaz , M A Titova , A Kh Odintsova , A P Kiyasov , G R Burganova , S R Abdulkhakov , A A Gumerova , I M Gazizov , T S Yilmaz , M A Titova , A Kh Odintcova , A P Kiassov
Genes & Cells ›› 2012, Vol. 7 ›› Issue (3) : 34 -36.
Changes of the inflammatory activity and fibrosis in patients with alcoholic liver cirrhosis after autologoushematopoietic stem cell transplantation
Evaluation of treatment results of chronic liver diseasesshould be made on the basis of morphological analysis ofliver biopsies. The aim of our study was to investigate theeffect of autologous hematopoietic stem cell transplantationon histology activity index and grade of fibrosis in alcoholicliver cirrhosis patients. The study was performed on liverbiopsies of 11 patients with alcoholic liver cirrhosis. Biopsieswere taken before the injection of autologous peripheralblood stem cells into celiac trunk, 3 and 12 months afterthe procedure. Liver biopsy specimens were stained withhematoxylin-eosin and Van Gieson's. Results showedimprovement of liver structure and decrease in histologyactivity index in liver biopsies performed 3 and 12 monthsafter transplantation. Our data suggest that autologoustransplantation of hematopoietic stem cell in patients withalcoholic liver cirrhosis is effective method that is capableto reduce inflammation activity in the liver, improve itsstructure and decrease liver fibrogenesis.
alcoholic liver cirrhosis / hematopoietic stem cells / transplantation / regeneration / liver fibrosis
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