Search of an optimum variant of cell therapy of a critical limbs ischemia in experiment
O V Maslyanyuk, , V N Alexandrov, , V S Chirsky, , A V Kriventsov, , A G Maximov, , V P Rumakin, , L I Kalyuzhnaya
Genes & Cells ›› 2011, Vol. 6 ›› Issue (3) : 41 -45.
Search of an optimum variant of cell therapy of a critical limbs ischemia in experiment
The search of new way of cell injection that can providemaximal angiogenesis in ischemic limbs is urgent aim ofinvestigation for the right way of cell delivery other thingsbeing equal is the main request for cell therapy efficiency.On experimental model of critical ischemia (by angiographicmethod and evaluation of capillary density on histologicalsections) it was shown that cell therapy independently fromthe way of cell injection (intramuscularly, intra-arterialy andcombined) induces angiogenesis, the rate and intensity ofwhich depend on the way of cell delivery. The optimum variantof cell therapy of critical ischemia is combined (intramusculararterial)method of cell injection, uniting the advantages ofintramuscular and intra-arterial ways.
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