The effect of mesenchymal stromal cells and the mobilization of stem cells in bone marrow on the development of nephrosclerosis

Abstract

The effects of autologous mesenchymal stromal cell CMSC) transplantation and of bone marrow IBM) hematopoietic cells mobilization on the course of rhabdomyolysis-induced nephropathy in mice were studied. Both MSC transplantation and mobilization of hematopoietic BM cells were demonstrated to improve function and to inhibit fibrotic transformation of the kidney. At the same time MSC transplantation had no impact on the levels of mononuclear infiltration and on the casts formation, but decreased systemic proinflammatory responsiveness. Mobilization of BM hematopoietic cells, on the contrary, enhanced the levels of mononuclear infiltration and casts formation in renal tissue, but did not alter the systemic proinflammatory responsiveness. Both MSC transplantation and BM hematopoietic cells mobilization were concluded to be the most promising approaches to the development of novel therapeutic methods to treat progressive nephropathy.

Keywords

nehprosclerosis / mesenchymal stromal cell / hematopoietic cell mobilization

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