Umbilical cord blood as a source for allogeneic stem cell transplantation in children (the experience of Moscow Stem Cell Bank)

T V Shamanskaya; T A Astrelina; Z A Podkolzina; E E Karpova; L L Lebedeva; E E Skorobogatova; O B Paina; M B Yakovleva; T V Shamanskaya; Т А Astrelina; E A Podkolzina; E E Karpova; L L Lebedeva; E V Skorobogatova; O V Paina; M V Yakovleva

doi:10.23868/gc121465

Genes & Cells ›› 2010, Vol. 5 ›› Issue (2) : 29 -35. DOI: 10.23868/gc121465

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Umbilical cord blood as a source for allogeneic stem cell transplantation in children (the experience of Moscow Stem Cell Bank)

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Stem Cell Bank, MoscowFederal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow

Stem Cell Bank, Moscow

Federal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, MoscowRussian Children Clinical Hospital, Moscow

St. Peterburg Pavlov State Medical University, Memorial R.M. Gorbacheva Institute of Children Hematology, St. Peterburg

Stem Cell Bank, MoscowFederal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, Moscow

Stem Cell Bank, Moscow

Federal Clinical Research Center of Pediatric Hematology, Oncology and Immunology, MoscowRussian Children Clinical Hospital, Moscow

St. Peterburg Pavlov State Medical University, Memorial R.M. Gorbacheva Institute of Children Hematology, St. Peterburg

Stem Cell Bank, Moscow

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Abstract

The results of hematopoetic stem cell transplantation [HSCTJ of cord blood units collected by Stem Cell Bank of Moscow are described. From August 200Б till August 2009 1Б children with malignant hematological and non-malignant diseases have undergone umbilical cord blood transplantation ШСВТ). The median number of total nucleated cells and CD34+ cells infused was B,Ox107/kg [range 0,2-21,5) and 7,7x105/kg [range 0,5-40), accordingly. 9 (5B,25%) patients showed engraftment. The median time to neutrophil engraftment was 24 days [range 15-ЗБ). Acute GVHD grade l-ll was observed in 7[43,75%) patients, there were no cases of severe GVHD. Chronic GVHD was noted in KB,25%) patient. The transplant-related mortality at 100 days was 28,5%. The overall survival was 5B,2%, with a median time of observation of 11Б days. The results of our study showed that UCB is an alternative source of stem cells for HSCT in patients with malignant and non-malignant diseases.

Keywords

umbilical cord blood bank / umbilical cord blood / umbilical cord blood transplantation

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T V Shamanskaya, T A Astrelina, Z A Podkolzina, E E Karpova, L L Lebedeva, E E Skorobogatova, O B Paina, M B Yakovleva, T V Shamanskaya, Т А Astrelina, E A Podkolzina, E E Karpova, L L Lebedeva, E V Skorobogatova, O V Paina, M V Yakovleva. Umbilical cord blood as a source for allogeneic stem cell transplantation in children (the experience of Moscow Stem Cell Bank). Genes & Cells, 2010, 5(2): 29-35 DOI:10.23868/gc121465

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