Genomic and non-genomic effects of glucocorticoids

N. M Todosenko , Yu. A Koroleva , O. G Khaziakhmatova , K. A Yurova , L. S Litvinova

Genes & Cells ›› 2017, Vol. 12 ›› Issue (1) : 27 -33.

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Genes & Cells ›› 2017, Vol. 12 ›› Issue (1) : 27 -33. DOI: 10.23868/gc120636
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Genomic and non-genomic effects of glucocorticoids

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Abstract

The overview describes the structure of a classic nuclear glucocorticoid receptor associated bound in inactive form to proteins chaperone complex. We analyzed genomic mechanisms regulated the gene expression, as well as a fastacting glucocorticoid effects of not genomic nature.

Keywords

glucocorticoids / nuclear receptors / gene expression / inflammation

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N. M Todosenko, Yu. A Koroleva, O. G Khaziakhmatova, K. A Yurova, L. S Litvinova. Genomic and non-genomic effects of glucocorticoids. Genes & Cells, 2017, 12(1): 27-33 DOI:10.23868/gc120636

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References

[1]

Jiang Ch.L., Liu L., Li Zh. et al. The novel strategy of glucocorticoid drug development via targeting nongenomic mechanisms. Steroids 2015; 102: 27-31.

[2]

Adcock I.M., Caramori G. Cross-talk between pro-inflammatory transcription factors and glucocorticoids. Immunology and Cell Biology 2001; 79(4): 376-84.

[3]

Garcia-Magallon B., Silva-Fernandez L., Andreu-Sanchez J.L. et al. Update on the Use of Steroids in Rheumatoid Arthritis. Reumatol. Clin. 2013; 9(5): 297-302.

[4]

Saleh K.J., Kurdi A.J., El-Othmani M.M. et al. Perioperative Treatment of Patients with Rheumatoid Arthritis. J. Am. Acad. Orthop. Surg. 2015; 23(9): 38-48.

[5]

Zampeli E., Vlachoyiannopoulos P.G., Tzioufas A.G. Treatment of rheumatoid arthritis: Unraveling the conundrum. Journal of Autoimmunity 2015; 65: 1-18.

[6]

Black R.J., Joseph R.M., Brown B. et al. Half of UK patients with rheumatoid arthritis are prescribed oral glucocorticoid therapy in primary care: a retrospective drug utilisation study. Arthritis Research & Therapy 2015; 17: 375.

[7]

Oppong E., Cato A.C.B. Effects of Glucocorticoids in the Immune System. In: Wang J.C., Harris Ch., editors. Glucocorticoid signaling from molecules to mice to man. Advances in Experimental Medicine and Biology. New York: Springer; 2015. p. 217-33.

[8]

John K., Marino J.S., Sanchez E.R. et al. The glucocorticoid receptor: cause of or cure for obesity? Am. J. Physiol. Endocrinol. Metab. 2016; 310(4): 249-57.

[9]

Cruz-Topete D., Cidlowski J.A. One hormone, two actions: anti- and pro-Inflammatory effects of glucocorticoids. Neuroimmunomodulation 2015; 22(1-2): 20-32.

[10]

Baschant U., Tuckermann J. The role of the glucocorticoid receptor in inflammation and immunity. Journal of Steroid Biochemistry & Molecular Biology 2010; 120(2-3): 69-75.

[11]

Revollo J.R., Cidlowski J.A. Mechanisms generating diversity in glucocorticoid receptor signaling. Glucocorticoids and Mood: Ann. N.Y. Acad. Sci. 2009; 1179: 167-78.

[12]

Ratman D., Berghe W.V., Dejager L. et al. How glucocorticoid receptors modulate the activity of other transcription factors: A scope beyond tethering. Molecular and Cellular Endocrinology 2013; 380(1-2): 41-54.

[13]

Bazso A., Szappanos A., Patocs A. et al. The importance of glucocorticoid receptors in systemic lupus erythaematosus. A systematic review. Autoimmun. Rev. 2015; 14(4): 349-51.

[14]

Ayroldi E., Macchiarulo A., Riccardi C. Targeting glucocorticoid side effects: selective glucocorticoid receptor modulator or glucocorticoidinduced leucine zipper? A perspective. Faseb J. 201 4; 28(12): 5055-70.

[15]

Hartmann K., Koenen M., Schauer S. et al. Molecular Actions of Glucocorticoids in Cartilage and Bone During Health, Disease, and Steroid Therapy. Physiol. Rev. 2016; 96(2): 409-47.

[16]

Silverman M.N., Sternberg E.M. Glucocorticoid regulation of inflammation and its functional correlates: from HPA axis to glucocorticoid receptor dysfunction. Ann. N.Y. Acad. Sci. 2012; 1261: 55-63.

[17]

Ingawale D.K., Mandlik S.K., Patel S.S. An emphasis on molecular mechanisms of anti-inflammatory effects and glucocorticoid resistance. J. Complement Integr. Med. 2015; 12(1): 1-13.

[18]

Bamberger C.M., Bamberger A.M., de Castro M. et al. Glucocorticoid receptor beta, a potential endogenous inhibitor of glucocorticoid action in humans. J. Clin. Invest. 1995; 95(6): 2435-41.

[19]

Nicolaides N.C., Galata Z., Kino T. et al. The human glucocorticoid receptor: molecular basis of biologic function. Steroids 2010; 75(1): 1-12.

[20]

Oakley R.H., Sar M., Cidlowski J.A. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J. Biol. Chem. 1996; 271(16): 9550-9.

[21]

Ray D.W., Davis J.R., White A. et al. Glucocorticoid receptor structure and function in glucocorticoid-resistant small cell lung carcinoma cells. Cancer Res. 1996; 56(14): 3276-80.

[22]

Kelly A., Bowen H., Jee Y.K. et al. The glucocorticoid receptor beta isoform can mediate transcriptional repression by recruiting histone deacetylases. J. Allergy Clin. Immunol. 2008; 121(1): 203-8.

[23]

Kim S.H., Kim D.H., Lavender P. et al. Repression of TNF -а-induced IL-8 expression by the glucocorticoid receptor involves inhibition of histone H4 acetylation. Exp. Mol. Med. 2009; 41(5): 297-306.

[24]

Li L.B., Leung D.Y.M., Martin R.J. et al. Inhibition of histone deacetylase 2 expression by elevated glucocorticoid receptor in steroid-resistant asthma. Am. J. Respir. Crit. Care Med. 2010; 182(7): 877-83.

[25]

Lui J.C., Nilsson O., Baron J. Growth plate senescence and catch-up growth. Endocr. Dev. 2011; 21: 23-9.

[26]

Grad I., Picard D. The glucocorticoid responses are shaped by molecular chaperones. Mol. Cell Endocrinol. 2007; 275(1-2): 2-12.

[27]

Pratt W.B. The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor. J. Biol. Chem. 1993; 268(29): 21455-8.

[28]

Pratt W.B., Toft D.O. Regulation of signaling protein function and trafficking by the hsp90/hsp70-based chaperone machinery. Exp. Biol. Med. 2003; 228(2): 111-33.

[29]

Pratt W.B., Toft D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 1997; 18(3): 306-60.

[30]

Riggs D.L., Roberts P.J., Chirillo S.C. et al. The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo. EMBO J. 2003; 22(5): 1158-67.

[31]

Vermeer H., Hendriks-Stegeman B.I., van der Burg B. et al. Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability. J. Clin. Endocrinol. Metab. 2003; 88(1): 277-84.

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