Efficiency of autofibroblasts in surgical treatment of parodontitis

A. I Grudyanov; V. L Zorin; R. V Pereverzev; A. I Zorina; I. Y Bozo

doi:10.23868/gc120544

Genes & Cells ›› 2013, Vol. 8 ›› Issue (3) : 72 -77. DOI: 10.23868/gc120544

Articles

research-article

Efficiency of autofibroblasts in surgical treatment of parodontitis

Author information +

History +

PDF

Abstract

The destructive forms of periodontal disease have a high prevalence. Our study was aimed to evaluate the effectiveness of tissue-engineering osteoplastic material in treatment of patients with periodontal pathology. We have obtained autologous gingival fibroblasts of patients, combined with the hydroxyapatite carriage and transplanted on a standard surgical treatment of periodontitis destructive forms. As a control we used the material without cells implanted into periodontal defects of other affected teeth of the same patients. We have shown the better effect of tissue-engineering osteoplastic material regarding the periodontal pockets depth, but significant difference in bone regeneration and other indicators has not been revealed. Thus, a continuation of researches is required to modify the technology of tissueengineering osteoplastic material creation and to choice the more optimal carrier for gingival fibroblasts.

Keywords

gingival fibroblasts / tissue-engineering osteoplastic material / periodontal disease / clinical study

Cite this article

Download citation ▾

A. I Grudyanov, V. L Zorin, R. V Pereverzev, A. I Zorina, I. Y Bozo. Efficiency of autofibroblasts in surgical treatment of parodontitis. Genes & Cells, 2013, 8(3): 72-77 DOI:10.23868/gc120544

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Безрукова И.В. Быстропрогрессирующий пародонтит. М.: Медицинская книга; 2004.

[2]	Григорьян А.С., Грудянов А.И., Фролова О.А. и др. Видовой состав анаэробной микрофлоры пародонтального кармана в зависимости от стадии пародонтита. Стоматология 2009; 4: 43-7.

[3]	Грудянов А.И. Заболевания пародонта. М.: Медицинское информационное агентство; 2009.

[4]	Petersen P.E., Ogawa H. Strengthening the prevention of periodontal disease: the WHO approach. Periodontol 2005; 76: 2187-93.

[5]	Григорьян А.С., Грудянов А.И., Рабухина Н.А. Болезни паро-донта: патогенез, диагностика, лечение. М.: Медицинское информационное агентство; 2004.

[6]	Bowers G.M., Chadroff B., Carnevale R. et al. Histologic evaluation of new attachment apparatus formation in humans. Part III. Periodontol. 1989; 60(12): 683-93.

[7]	Cortellini P, Bowers G. Periodontal regeneration of intrabony defects: An evidence based treatment approach. Int. J. Periodontol. Rest. Dent. 1995; 15:128-45.

[8]	Гололобов В.Г., Дулаев А.К., Деев Р.В. и д.р. Морфофункциональная организация, реактивность и регенерация костной ткани. СПб: 2006; 47 с.

[9]	Зорин В.Л., Зорина А.И., Воложин Г.А. и др. Изучение фенотипического профиля и остеогенных свойств фибробластов десны. Саратовский научно-медицинский журнал 2013; 9(3): 393-7.

[10]	Lorenz K., Sicker M., Schmelzer E. et al. Multilineage differentiation potential of human dermal skin-derived fibroblasts. Exp. Dermatol. 2008; 17(11): 925-32

[11]	Mostafa N.Z., Uludag H., Varkey M. et al. In vitro osteogenic induction of human gingival fibroblasts for bone regeneration. Open Dent J. 2011;5:139-45.

[12]	Huang G.T., Gronthos S., Shi S. Mesenchymal stem cells derived from dental tissues vs. those from other sources: their biology and role in regenerative medicine. J. Dent. Res. 2009; 88(9): 792806.

[13]	Guo W., Chen L., Gong K. et al. Heterogeneous dental follicle cells and the regeneration of complex periodontal tissues. Tissue Eng. Part A. 2012; 18(5-6): 459-70.