The role of cytokine system RANKL/RANK/OPG in the regulation of bone metabolism

Abstract

The review describes the modern data concerning the cellular and molecular mechanisms of mineral metabolism disturbance in bone tissue. Cytokine system consisting of receptor activator of nuclear factor к-b, its ligand and osteoprotegerin (RANKL/RANK/OPG) has a key role in understanding of bone remodeling regulation. We discuss a significance of the cytokine system in osteoblasto- and osteoclastogenesis. Molecular processes of histogenesis and bone resorption have been analyzed.

Keywords

osteoporosis / cytokine system RANKL/RANK/ OPG / bone tissue / mineral metabolism / remodeling / osteoblast / osteoclast

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