The influence of P2-receptors on the cytotoxic effect of cisplatine in squamous cell uterine cervix cancer in vitro

I. S Raginov; G. K Muhamedyarova; A. V Panov

doi:10.23868/gc120330

Genes & Cells ›› 2014, Vol. 9 ›› Issue (3) :240 -241. DOI: 10.23868/gc120330

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The influence of P2-receptors on the cytotoxic effect of cisplatine in squamous cell uterine cervix cancer in vitro

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Abstract

To investigate the influence of purinergic signalling in squamous cell uterine cervix cancer in vitro, the effect of combining ATP (nonselective agonist P2-receptor) with the nonselective P2 receptor antagonists PPADS (P2X-receptors), RB2 (P2Y-receptors) and suramin (both P2Y-receptors and P2X-receptors) and the chemotherapeutic drug cisplatin was assessed. ATP effectively reduces up to twofold the growth of uterine cervix cancer cells. RB2 promoted survival of tumor cell by 52,1% compared to the control. Combinations of the cisplatin + ATP demonstrated a strong sensitivity at 2,7 fold. However, this effect of ATP was reversed in the presence of RB2 by 41%. This highlights the potential use of selective P2Y receptor agonists in the treatment of squamous cell uterine cervix cancer.

Keywords

chemotherapeutic drug / P2-receptors / uterine cervix cancer

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I. S Raginov, G. K Muhamedyarova, A. V Panov. The influence of P2-receptors on the cytotoxic effect of cisplatine in squamous cell uterine cervix cancer in vitro. Genes & Cells, 2014, 9(3): 240-241 DOI:10.23868/gc120330

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