EXPERIMENTAL ESTIMATION OF COMPOSITE MATERIAL CONTAINING THE PROTEIN-MINERAL COMPONENTS AND RECOMBINANT BONE MORPHOGENETIC PROTEIN-2 AS A COVERING OF TITANIUM IMPLANTS
M. Z. Fedorova , S. V. Nadezhdin , A. S. Semikhin , M. A. Lazebnaya , G. V. Khramov , Y. R. Kolobov , A. V. Gromov , M. S. Bartov , V. G. Lunin , A. S. Karyagina , D. V. Gunderov
Traumatology and Orthopedics of Russia ›› 2011, Vol. 17 ›› Issue (2) : 101 -106.
EXPERIMENTAL ESTIMATION OF COMPOSITE MATERIAL CONTAINING THE PROTEIN-MINERAL COMPONENTS AND RECOMBINANT BONE MORPHOGENETIC PROTEIN-2 AS A COVERING OF TITANIUM IMPLANTS
The influence of both, the composite material based on the protein-mineral components including the prolonged form of the recombinant human bone morphogenetic protein 2 (rhBMP-2) and the method of the titanium implant’s surface treatment, on the reparative osteogenesis and adhesion strength of the bone tissue – implant’s surface contact was evaluated. Covering of implants with the composite coating promotes significant acceleration of the bone tissue regeneration processes in the site of implants loading. The composition coating with prolonged form of the rhBMP-2 promoted increasing of the neogenic bone tissue’s adhesion with the implants, as compared with the coating without recombinant human bone morphogenetic protein. The implants treated with microarc oxidation demonstrated higher values of the breakout force during the separation of the implants from the bone than the implants treated with sandblasting method.
titanium implant / recombinant bone morphogenetic human protein-2
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