Benign fibrous histiocytoma of the femur: A rare pediatric case report

Abstract

BACKGROUND: Benign fibrous histiocytoma is known to be a frequent skin tumor but its occurrence in bone remains very rare especially in pediatric population. This entity is a subject of interest also because histologically it can mimic other fibrohistiocytic lesions of bone such as non-ossifying fibroma.

CLINICAL CASE: An 11-year-old patient admitted with swelling of the right thigh and intermittent pain. Radiological evaluation shows cystic lesion of the femur with a soap-bubble and a border of condensation. Histopathological examination of the biopsy sample established the diagnosis of benign fibrous histiocytoma. The patient underwent complete curettage of the lesion with bone graft. There is no recurrence 16 months after surgery.

DISCUSSION: Benign fibrous histiocytoma is a rare bone tumor especially in children. Histologically it can mimic non-ossifying fibroma. Thus clinical and radiological features are important to differentiate these tumors in order to choose adequate treatment.

CONCLUSIONS: Benign fibrous histiocytoma is probably underestimated in pediatric population. This diagnosis should be considered in any child or teenager who presents with a non-ossifying fibroma accompanied by unexplainable pain or a rapid growing.

Keywords

benign fibrous histiocytoma / children / bone tumour / surgical treatment

References

[1] Zizah S, Benabid M, Bennani A, et al. Un cas rare d’histiocytofibrome bénin de la cheville. Med Chir Pied. 2010;26(4):113–116.

[2] Zizah S., Benabid M., Bennani A., et al. Un cas rare d’histiocytofibrome bénin de la cheville // Med. Chir. Pied. 2010. Vol. 26. No. 4. P. 113–116.

[3] Mondal SK. Cytodiagnosis of benign fibrous histiocytoma of rib and diagnostic dilemma: A case report. Diagn Cytopathol. 2010;38(6):457−460. DOI: 10.1002/dc.21245

[4] Mondal S.K. Cytodiagnosis of benign fibrous histiocytoma of rib and diagnostic dilemma: A case report // Diagn. Cytopathol. 2010. Vol. 38. No. 6. P. 457−460. DOI: 10.1002/dc.21245

[5] Smaranda D, Stefana M, Doina M, et al. Benign fibrous histiocytoma in a child − A case report. American Journal of Medical Case Reports. 2016;4(1):19−21. DOI: 10.12691/ajmcr-4-1-6

[6] Smaranda D., Stefana M., Doina M., et al. Benign fibrous histiocytoma in a child − A case report // American Journal of Medical Case Reports. 2016. Vol. 4. No. 1. P. 19−21. DOI: 10.12691/ajmcr-4-1-6

[7] Kuruvath S, O’Donovan DG, Aspoas AR, David KM. Benign fibrous histiocytoma of the thoracic spine: case report and review of the literature. J Neurosurg Spine. 2006;4(3):260–264. DOI: 10.3171/spi.2006.4.3.260

[8] Kuruvath S., O’Donovan D.G., Aspoas A.R., David K.M. Benign fibrous histiocytoma of the thoracic spine: case report and review of the literature // J. Neurosurg. Spine. 2006. Vol. 4. No. 3. P. 260–264. DOI: 10.3171/spi.2006.4.3.260

[9] Hamada T, Ito H, Araki Y, et al. Benign fibrous histiocytoma of the femur: review of three cases. Skeletal Radiology. 1996;25(1):25–29.

[10] Hamada T., Ito H., Araki Y., et al. Benign fibrous histiocytoma of the femur: review of three cases // Skeletal Radiology. 1996. Vol. 25. No. 1. P. 25–29.

[11] El hyaoui H, Toua T, El koumiti N, et al. L’histiocytofibrome osseux bénin: une localisation humérale rare. J Afr Cancer. 2014;6(3):181–185.

[12] El hyaoui H., Toua T., El koumiti N., et al. L’histiocytofibrome osseux bénin: une localisation humérale rare // J. Afr. Cancer. 2014. Vol. 6. No. 3. P. 181–185.

[13] Campanacci M, Enneking WF. Benign fibrous histiocytoma. In: Campanacci M. (ed.). Bone and soft tissue tumors: clinical features, imaging, pathology and treatment. Wien, New York: Springer; 1999. P. 93–98.

[14] Campanacci M., Enneking W.F. Benign fibrous histiocytoma. In: Campanacci M. (ed.). Bone and soft tissue tumors: clinical features, imaging, pathology and treatment. Wien, New York: Springer, 1999. P. 93–98.

[15] Ceroni D, Dayer R, De Coulon G, Kaelin A. Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases. Musculoskelet Surg. 2011;95(2):107–114. DOI: 10.1007/s12306-011-0115-x

[16] Ceroni D., Dayer R., De Coulon G., Kaelin A. Benign fibrous histiocytoma of bone in a paediatric population: a report of 6 cases // Musculoskelet. Surg. 2011. Vol. 95. No. 2. P. 107–114. DOI: 10.1007/s12306-011-0115-x

[17] Macdonald D, Fornasier V, Holtby R. Benign fibrohistiocytoma (Xanthomatous variant) of the Acromion. A case report and review of the literature. Arch Pathol Lab Med. 2002;126(5):599−601. DOI: 10.5858/2002-126-0599-BFXVOT

[18] Macdonald D., Fornasier V., Holtby R. Benign fibrohistiocytoma (Xanthomatous variant) of the Acromion. A case report and review of the literature // Arch. Pathol. Lab. Med. 2002. Vol. 126. No. 5. P. 599−601. DOI: 10.5858/2002-126-0599-BFXVOT

[19] Sanatkumar S, Rajagopalan N, Mallikarjunaswamy B, et al. Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: A case report. J Orthop Surg (Hong Kong). 2005;13(1):83–87. DOI:10.1177/230949900501300116

[20] Sanatkumar S., Rajagopalan N., Mallikarjunaswamy B., et al. Benign fibrous histiocytoma of the distal radius with congenital dislocation of the radial head: A case report // J. Orthop. Surg. (Hong Kong). 2005. Vol. 13. No. 1. P. 83–87. DOI:10.1177/230949900501300116

[21] Amghar J. Rare case of benign bone histiocytofibroma of the proximal end of the tibia. 2020;6(3):1−3.

[22] Amghar J. Rare case of benign bone histiocytofibroma of the proximal end of the tibia. 2020. Vol. 6. No. 3. P. 1−3.

[23] Shimizu J, Emori M, Okada Y, et al. Arthroscopic resection for benign fibrous histiocytoma in the epiphysis of the femur. Case Rep Orthop. 2018;2018:8030862. DOI: 10.1155/2018/8030862

[24] Shimizu J., Emori M., Okada Y., et al. Arthroscopic resection for benign fibrous histiocytoma in the epiphysis of the femur // Case Rep. Orthop. 2018. Vol. 2018. P. 8030862. DOI: 10.1155/2018/8030862

[25] Bertoni F, Calderoni P, Bacchini P, et al. Benign fibrous histiocytoma of bone. J Bone Joint Surg Am. 1986;68(8):1225–1230.

[26] Bertoni F., Calderoni P., Bacchini P., et al. Benign fibrous histiocytoma of bone // J. Bone Joint Surg. Am. 1986. Vol. 68. No. 8. P. 1225–1230.

[27] Matsuno T. Benign fibrous histiocytoma involving the ends of long bone. Skeletal Radiol. 1990;19(8):561–566. DOI: 10.1007/BF00241277

[28] Matsuno T. Benign fibrous histiocytoma involving the ends of long bone // Skeletal. Radiol. 1990. Vol. 19. No. 8. P. 561–566. DOI: 10.1007/BF00241277

[29] Al-Jamali J, Gerlach UV, Zajonc H. Benign fibrous histocytoma of the distal radius: a report of a case and a review of the literature. Hand Surg. 2010;15(02):127–129. DOI: 10.1142/S0218810410004722

[30] Al-Jamali J., Gerlach U.V., Zajonc H. Benign fibrous histocytoma of the distal radius: a report of a case and a review of the literature // Hand. Surg. 2010. Vol. 15. No. 2. P. 127–129. DOI: 10.1142/S0218810410004722

[31] Keskinbora M, Köse Ö, Karslioglu Y, et al. Another cystic lesion in the calcaneus: Benign fibrous histiocytoma of bone. J Am Pediatr Med Assoc. 2013;103(2):141–144. DOI: 10.7547/1030141

[32] Keskinbora M., Köse Ö., Karslioglu Y., et al. Another cystic lesion in the calcaneus: Benign fibrous histiocytoma of bone // J. Am. Pediatr. Med. Assoc. 2013. Vol. 103. No. 2. P. 141–144. DOI: 10.7547/1030141

[33] Herget GW, Mauer D, Krauß T, et al. Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up. BMC Musculoskeletal Disorders. 2016;17(1):147. DOI: 10.1186/s12891-016-1004-0

[34] Herget G.W., Mauer D., Krauß T., et al. Non-ossifying fibroma: natural history with an emphasis on a stage-related growth, fracture risk and the need for follow-up // BMC Musculoskeletal. Disorders. 2016. Vol. 17. No. 1. P. 147. DOI: 10.1186/s12891-016-1004-0

[35] Fletcher CD, Hogendoorn CW, Mertens F, et al. WHO classification of tumours of soft tissue and bone. Lyon: IARC Press; 2013.

[36] Fletcher C.D., Hogendoorn C.W., Mertens F., et al. WHO classification of tumours of soft tissue and bone. Lyon: IARC Press, 2013.

[37] The WHO classification of tumours editorial board. WHO classification of tumours soft tissue and bone tumours. Lyon: IARC Press; 2020.

[38] The WHO classification of tumours editorial board. WHO classification of tumours soft tissue and bone tumours. Lyon: IARC Press, 2020.

[39] Clarke BE, Xipell JM, Thomas DP. Benign fibrous histiocytoma of bone. Am J Surg Pathol. 1985;9(11):806–815.

[40] Clarke B.E., Xipell J.M., Thomas D.P. Benign fibrous histiocytoma of bone // Am. J. Surg. Pathol. 1985. Vol. 9. No. 11. P. 806–815.

[41] Grohs JG, Nicolakis M, Kainberger F, et al. Benign fibrous histiocytoma of bone: a report of ten cases and review of literature. Wien Klin Wochenschr. 2002;114(1–2):56–63.

[42] Grohs J.G., Nicolakis M., Kainberger F., et al. Benign fibrous histiocytoma of bone: a report of ten cases and review of literature // Wien Klin. Wochenschr. 2002. Vol. 114. No. 1–2. P. 56–63.

RIGHTS & PERMISSIONS

Abdellaoui H., Tazi Charqui M., Balde F., Atarraf K., My Abderrahmane A.