Amplified pain and complex regional pain syndrome in children: clinical cases and literature review

Abstract

BACKGROUND: Musculoskeletal pain is a common reason for visiting pediatric clinics. Causes of chronic musculoskeletal pain include various inflammatory or noninflammatory conditions. Amplified pain syndrome refers to a wide range of conditions manifested by chronic pain, the common feature of which is central and/or peripheral sensory amplification of pain. Complex regional pain syndrome is characterized by spontaneously occurring or provoked by irritating stimuli pain of high intensity, disproportionate to the actual injury or other stimulus, and the presence of several concomitant vegetative and motor disorders.

CLINICAL CASES: This article presents three clinical cases of pediatric patients with chronic musculoskeletal pain and an analysis of the current literature on chronic pain in children.

DISCUSSION: Complex regional pain syndrome is more common in adolescent girls, and conflict or psychological trauma is a common trigger. Symptoms of disproportionate burning pain (causalgia) with trophic changes may indicate complex regional pain syndrome. To date, there are no generally accepted pharmacological treatments recommended for children with complex regional pain syndrome. Nonsteroidal anti-inflammatory drugs (ibuprofen) and paracetamol and their combination are commonly administered in cases wherein symptoms of chronic pain first appear.

CONCLUSIONS: Currently, a multidisciplinary approach, including physical, psychological, medical, and invasive methods, appears to be the most adequate treatment method for musculoskeletal pain. The use of analgesics should comply with approved protocols of pain management in pediatric practice.

Keywords

amplified pain / complex regional pain syndrome / children

References

[1] Kenis VM. Current concepts in the diagnosis and management of acute pain in children. Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2024;12(1):139–150. EDN: BUXLML doi: 10.17816/PTORS627283

[2] Кенис В.М. Современные представления о диагностике и лечении острой боли у детей // Ортопедия, травматология и восстановительная хирургия детского возраста. 2024. Т. 12, № 1. C. 139–150. EDN: BUXLML doi: 10.17816/PTORS627283

[3] Hoffart CM, Wallace DP. Amplified pain syndromes in children: treatment and new insights into disease pathogenesis. Curr Opin Rheumatol. 2014;26(5):592–603. doi: 10.1097/BOR.0000000000000097

[4] Hoffart C.M., Wallace D.P. Amplified pain syndromes in children: treatment and new insights into disease pathogenesis // Curr Opin Rheumatol. 2014. Vol. 26, N 5. P. 592–603. doi: 10.1097/BOR.0000000000000097

[5] Weissmann R, Uziel Y. Pediatric complex regional pain syndrome: a review. Pediatr Rheumatol Online J. 2016;14(1):29. doi: 10.1186/s12969-016-0090-8

[6] Weissmann R., Uziel Y. Pediatric complex regional pain syndrome: a review // Pediatr Rheumatol Online J. 2016. Vol. 14, N 1. P. 29. doi: 10.1186/s12969-016-0090-8

[7] Kulyaba TA, Koryachkin AV, Kornilov NN, et al. Reflex sympathetic dystrophy (complex regional pain pain syndrome type I) – etiopathogenesis, diagnosis, treatment (literature review). Department of traumatology and orthopedics. 2019;(1):22–29. EDN: SUVZUV doi: 10.17238/issn2226-2016.2019.1.22-29

[8] Куляба Т.А., Корячкин. А.В., Корнилов Н.Н., и др. Рефлекторная симпатическая дистрофия (комплексный регионарный болевой синдром I типа) – этиопатогенез, диагностика, лечение (обзор литературы) // Кафедра травматологии и ортопедии. 2019. № 1(35). С. 22–29. EDN: SUVZUV doi: 10.17238/issn2226-2016.2019.1.22-29

[9] Rubashkin SA, Sertakova AV, Rubashkin AS. Complex regional pain syndrome in children: literature review and clinical observation from the practice of a traumatologist-orthopedist. Pediatrics. Journal named after G.N. Speransky. 2023;102(5):230–236. EDN: HBCJJL doi: 10.24110/0031-403X-2023-102-5-230-236

[10] Рубашкин С.А., Сертакова А.В., Рубашкин А.С. Комплексный регионарный болевой синдром у детей: обзор литературы и клиническое наблюдение из практики врача — травматолога-ортопеда // Педиатрия. Журнал им. Г.Н. Сперанского. 2023. Т. 102, № 5. С. 230–236. EDN: HBCJJL doi: 10.24110/0031-403X-2023-102-5-230-236

[11] Merkulov VN, Dorokhin AI, Krupatkin AI, et al. Treatment of type 1 complex regional pain syndrome in 14 years old child. N.N. Priorov Journal of Traumatology and Orthopedics. 2014;21(4):79–82. EDN: TIGMGX doi: 10.17816/vto20140479-82

[12] Меркулов В.Н., Дорохин А.И., Крупаткин А.И., др. Лечение комплексного регионарного болевого синдрома 1 типа у ребенка 14 лет // Вестник травматологии и ортопедии им Н.Н. Приорова. 2014. Т. 21, № 4. C. 79–82. EDN: TIGMGX doi: 10.17816/vto20140479-82

[13] Ho ES, Ponnuthurai J, Clarke HM. The incidence of idiopathic musculoskeletal pain in children with upper extremity injuries. J Hand Ther. 2014;27(1):38–43. doi: 10.1016/j.jht.2013.10.002

[14] Ho E.S., Ponnuthurai J., Clarke H.M. The incidence of idiopathic musculoskeletal pain in children with upper extremity injuries // J Hand Ther. 2014. Vol. 27, N 1. P. 38–43. doi: 10.1016/j.jht.2013.10.002

[15] Borucki AN, Greco CD. An update on complex regional pain syndromes in children and adolescents. Curr Opin Pediatr. 2015;27(4):448–452. doi: 10.1097/MOP.0000000000000250

[16] Borucki A.N., Greco C.D. An update on complex regional pain syndromes in children and adolescents // Curr Opin Pediatr. 2015. Vol. 27, N 4. P. 448–452. doi: 10.1097/MOP.0000000000000250

[17] Cruz N, O’Reilly J, Slomine BS, et al. Emotional and neuropsychological profiles of children with complex regional pain syndrome type I in an inpatient rehabilitation setting. Clin J Pain. 2011;27(1):27–34. doi: 10.1097/AJP.0b013e3181f15d95

[18] Cruz N., O’Reilly J., Slomine B.S., et al. Emotional and neuropsychological profiles of children with complex regional pain syndrome type I in an inpatient rehabilitation setting // Clin J Pain. 2011. Vol. 27, N 1. P. 27–34. doi: 10.1097/AJP.0b013e3181f15d95

[19] Logan DE, Williams SE, Carullo VP, et al. Children and adolescents with complex regional pain syndrome: more psychologically distressed than other children in pain? Pain Res Manag. 2013;18(2):87–93. doi: 10.1155/2013/964352

[20] Logan D.E., Williams S.E., Carullo V.P., et al. Children and adolescents with complex regional pain syndrome: more psychologically distressed than other children in pain? // Pain Res Manag. 2013. Vol. 18, N 2. P. 87–93. doi: 10.1155/2013/964352

[21] Aasland A, Flatö B, Vandvik IH. Psychosocial factors in children with idiopathic musculoskeletal pain: a prospective, longitudinal study. Acta Paediatr. 1997;86(7):740–746. doi: 10.1111/j.1651-2227.1997.tb08578.x

[22] Aasland A., Flatö B., Vandvik I.H. Psychosocial factors in children with idiopathic musculoskeletal pain: a prospective, longitudinal study // Acta Paediatr. 1997. Vol. 86, N 7. P. 740–746. doi: 10.1111/j.1651-2227.1997.tb08578.x

[23] Geertzen JH, de Bruijn-Kofman AT, de Bruijn HP, et al. Stressful life events and psychological dysfunction in complex regional pain syndrome type I. Clin J Pain. 1998;14(2):143–147. doi: 10.1097/00002508-199806000-00009

[24] Geertzen J.H., de Bruijn-Kofman A.T., de Bruijn H.P., et al. Stressful life events and psychological dysfunction in complex regional pain syndrome type I // Clin J Pain. 1998. Vol. 14, N 2. P. 143–147. doi: 10.1097/00002508-199806000-00009

[25] Sherry DD, Weisman R. Psychologic aspects of childhood reflex neurovascular dystrophy. Pediatrics. 1988;81(4):572–578.

[26] Sherry D.D., Weisman R. Psychologic aspects of childhood reflex neurovascular dystrophy // Pediatrics. 1988. Vol. 81, N 4. P. 572–578.

[27] Nicol AL, Sieberg CB, Clauw DJ, et al. The association between a history of lifetime traumatic events and pain severity, physical function, and affective distress in patients with chronic pain. J Pain. 2016;17(12):1334–1348. doi: 10.1016/j.jpain.2016.09.003

[28] Nicol A.L., Sieberg C.B., Clauw D.J., et al. The association between a history of lifetime traumatic events and pain severity, physical function, and affective distress in patients with chronic pain // J Pain. 2016. Vol. 17, N 12. P. 1334–1348. doi: 10.1016/j.jpain.2016.09.003

[29] Sethna NF, Meier PM, Zurakowski D, et al. Cutaneous sensory abnormalities in children and adolescents with complex regional pain syndromes. Pain. 2007;131(1–2):153–161. doi: 10.1016/j.pain.2006.12.028

[30] Sethna N.F., Meier P.M., Zurakowski D., et al. Cutaneous sensory abnormalities in children and adolescents with complex regional pain syndromes // Pain. 2007. Vol. 131, N 1–2. P. 153–161. doi: 10.1016/j.pain.2006.12.028

[31] Low AK, Ward K, Wines AP. Pediatric complex regional pain syndrome. J Pediatr Orthop. 2007;27(5):567–572. doi: 10.1097/BPO.0b013e318070cc4d

[32] Low A.K., Ward K., Wines A.P. Pediatric complex regional pain syndrome // J Pediatr Orthop. 2007. Vol. 27, N 5. P. 567–572. doi: 10.1097/BPO.0b013e318070cc4d

[33] Agrawal SK, Rittey CD, Harrower NA, et al. Movement disorders associated with complex regional pain syndrome in children. Dev Med Child Neurol. 2009;51(7):557–562. doi: 10.1111/j.1469-8749.2008.03181.x

[34] Agrawal S.K., Rittey C.D., Harrower N.A., et al. Movement disorders associated with complex regional pain syndrome in children // Dev Med Child Neurol. 2009. Vol. 51, N 7. P. 557–562. doi: 10.1111/j.1469-8749.2008.03181.x

[35] Krupatkin AI, Golubev VG, Merkulov MV. Neurovascular aspects of post-traumatic complex regional pain syndrome (CRPS). Regional blood circulation and microcirculation. 2007;6(1):93–94. EDN: HZGUBZ (In Russ.)

[36] Крупаткин А.И., Голубев В.Г., Меркулов М.В. Нейро-сосудистые аспекты посттравматического комплексного регионарного болевого синдрома (КРБС) // Регионарное кровообращение и микроциркуляция. 2007. Т. 6, № 1(21). С. 93–94. EDN: HZGUBZ

[37] Lebel A, Becerra L, Wallin D, et al. fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children. Brain. 2008;131(Pt 7):1854–1879. doi: 10.1093/brain/awn123

[38] Lebel A., Becerra L., Wallin D., et al. fMRI reveals distinct CNS processing during symptomatic and recovered complex regional pain syndrome in children // Brain. 2008. Vol. 131, Pt. 7. P. 1854–1879. doi: 10.1093/brain/awn123

[39] Suponeva NA, Belova NV, Zaitseva NI. Small fiber neuropathy. Annals of clinical and experimental neurology. 2017;11(1):73–79. EDN: YJJZFR

[40] Супонева Н.А., Белова Н.В., Зайцева Н.И. Невропатия тонких волокон / // Анналы клинической и экспериментальной неврологии. 2017. Т. 11, № 1. С. 73–79. EDN: YJJZFR

[41] Oaklander AL, Fields HL. Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? Ann Neurol. 2009;65(6):629–638. doi: 10.1002/ana.21692

[42] Oaklander A.L., Fields H.L. Is reflex sympathetic dystrophy/complex regional pain syndrome type I a small-fiber neuropathy? // Ann Neurol. 2009. Vol. 65, N 6. P. 629–638. doi: 10.1002/ana.21692

[43] Alexander GM, Peterlin BL, Perreault MJ, et al. Changes in plasma cytokines and their soluble receptors in complex regional pain syndrome. J Pain. 2012;13(1):10–20. doi: 10.1016/j.jpain.2011.10.003

[44] Alexander G.M., Peterlin B.L., Perreault M.J., et al. Changes in plasma cytokines and their soluble receptors in complex regional pain syndrome // J Pain. 2012. Vol. 13, N 1. P. 10–20. doi: 10.1016/j.jpain.2011.10.003

[45] Alexander GM, van Rijn MA, van Hilten JJ, et al. Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS. Pain. 2005;116(3):213–219. doi: 10.1016/j.pain.2005.04.013

[46] Alexander G.M., van Rijn M.A., van Hilten J.J., et al. Changes in cerebrospinal fluid levels of pro-inflammatory cytokines in CRPS // Pain. 2005. Vol. 116, N 3. P. 213–219. doi: 10.1016/j.pain.2005.04.013

[47] Parkitny L, McAuley JH, Di Pietro F, et al. Inflammation in complex regional pain syndrome: a systematic review and meta-analysis. Neurology. 2013 80(1):106–117. doi: 10.1212/WNL.0b013e31827b1aa1

[48] Parkitny L., McAuley J.H., Di Pietro F., et al. Inflammation in complex regional pain syndrome: a systematic review and meta-analysis // Neurology. 2013. Vol. 80, N 1. P. 106–17. doi: 10.1212/WNL.0b013e31827b1aa1

[49] Goldschneider KR. Complex regional pain syndrome in children: asking the right questions. Pain Res Manag. 2012;17(6):386–390. doi: 10.1155/2012/854159

[50] Goldschneider K.R. Complex regional pain syndrome in children: asking the right questions // Pain Res Manag. 2012. Vol. 17, N 6. P. 386–390. doi: 10.1155/2012/854159

[51] Huygen FJ, De Bruijn AG, De Bruin MT, et al. Evidence for local inflammation in complex regional pain syndrome type 1. Mediators Inflamm. 2002;11(1):47–51. doi: 10.1080/09629350210307

[52] Huygen F.J., De Bruijn A.G., De Bruin M.T., et al. Evidence for local inflammation in complex regional pain syndrome type 1 // Mediators Inflamm. 2002. Vol. 11, N 1. P. 47–51. doi: 10.1080/09629350210307

[53] Sherry DD, McGuire T, Mellins E, et al. Psychosomatic musculoskeletal pain in childhood: clinical and psychological analyses of 100 children. Pediatrics. 1991;88(6):1093–1099.

[54] Sherry D.D., McGuire T., Mellins E., et al. Psychosomatic musculoskeletal pain in childhood: clinical and psychological analyses of 100 children // Pediatrics. 1991. Vol. 88, N 6. P. 1093–1099.

[55] Cappello ZJ, Kasdan ML, Louis DS. Meta-analysis of imaging techniques for the diagnosis of complex regional pain syndrome type I. J Hand Surg Am. 2012;37(2):288–296. doi: 10.1016/j.jhsa.2011.10.035

[56] Cappello Z.J., Kasdan M.L., Louis D.S. Meta-analysis of imaging techniques for the diagnosis of complex regional pain syndrome type I // J Hand Surg Am. 2012. Vol. 37, N 2. P. 288–296. doi: 10.1016/j.jhsa.2011.10.035

[57] Harden NR, Bruehl S, Perez RSGM, et al. Validation of proposed diagnostic criteria (the “Budapest сriteria”) for complex regional pain syndrome. Pain. 2010;150(2):268–274. doi: 10.1016/j.pain.2010.04.030

[58] Harden N.R., Bruehl S., Perez R.S.G.M., et al. Validation of proposed diagnostic criteria (the “Budapest сriteria”) for complex regional pain syndrome // Pain. 2010. Vol. 150, N 2. P. 268–274. doi: 10.1016/j.pain.2010.04.030

[59] Krupatkin AI, Golubev VG, Berglezov MA. Early diagnostics of posttraumatic complex regional pain syndrome. N.N. Priorov Journal of Traumatology and Orthopedics. 2006;(1):39–43. EDN: HUMLJP

[60] Крупаткин А.И., Голубев В.Г., Берглезов М.А. Ранняя диагностика посттравматического комплексного регионарного болевого синдрома // Вестник травматологии и ортопедии им. Н.Н. Приорова. 2006. № 1. С. 39–43. EDN: HUMLJP

[61] Winston P. Early treatment of acute complex regional pain syndrome after fracture or injury with prednisone: why is there a failure to treat? A case series. Pain Res Manag. 2016;2016. doi: 10.1155/2016/7019196

[62] Winston P. Early treatment of acute complex regional pain syndrome after fracture or injury with prednisone: why is there a failure to treat? A case series // Pain Res Manag. 2016. Vol. 2016. doi: 10.1155/2016/7019196

[63] O’Connell NE, Wand BM, McAuley J, Marston L, Moseley GL. Interventions for treating pain and disability in adults with complex regional pain syndrome. Cochrane Database Syst Rev. 2013;2013(4). doi: 10.1002/14651858.CD009416.pub2

[64] O’Connell N.E., Wand B.M., McAuley J., et al. Interventions for treating pain and disability in adults with complex regional pain syndrome // Cochrane Database Syst Rev. 2013. Vol. 2013, N 4. doi: 10.1002/14651858.CD009416.pub2

[65] Harden RN, Oaklander AL, Burton AW, et al.; Reflex Sympathetic Dystrophy Syndrome Association. Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition. Pain Med. 2013;14(2):180–229. doi: 10.1111/pme.12033

[66] Harden R.N., Oaklander A.L., Burton A.W., et al; Reflex Sympathetic Dystrophy Syndrome Association. Complex regional pain syndrome: practical diagnostic and treatment guidelines, 4th edition // Pain Med. 2013. Vol. 14, N 2. P. 180–229. doi: 10.1111/pme.12033

[67] Donado C, Lobo K, Velarde-Álvarez MF, et al. Continuous regional anesthesia and inpatient rehabilitation for pediatric complex regional pain syndrome. Reg Anesth Pain Med. 2017;42(4):527–534. doi: 10.1097/AAP.0000000000000593

[68] Donado C., Lobo K., Velarde-Álvarez M.F., et al. Continuous regional anesthesia and inpatient rehabilitation for pediatric complex regional pain syndrome // Reg Anesth Pain Med. 2017. Vol. 42, N 4. P. 527–534. doi: 10.1097/AAP.0000000000000593

[69] Lascombes P, Mamie C. Complex regional pain syndrome type I in children: what is new? Orthop Traumatol Surg Res. 2017;103(1S):S135–S142. doi: 10.1016/j.otsr.2016.04.017

[70] Lascombes P., Mamie C. Complex regional pain syndrome type I in children: what is new? // Orthop Traumatol Surg Res. 2017. Vol. 103, N 1S. P. S135–S142. doi: 10.1016/j.otsr.2016.04.017

[71] Lynch-Jordan AM, Sil S, Peugh J, et al. Differential changes in functional disability and pain intensity over the course of psychological treatment for children with chronic pain. Pain. 2014;155(10):1955–1961. doi: 10.1016/j.pain.2014.06.008

[72] Lynch-Jordan A.M., Sil S., Peugh J., et al. Differential changes in functional disability and pain intensity over the course of psychological treatment for children with chronic pain // Pain. 2014. Vol. 155, N 10. P. 1955–1561. doi: 10.1016/j.pain.2014.06.008

[73] Fisher E, Law E, Palermo TM, et al. Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children and adolescents. Cochrane Database Syst Rev. 2015;3(3). doi: 10.1002/14651858.CD011118.pub2

[74] Fisher E., Law E., Palermo T.M., et al. Psychological therapies (remotely delivered) for the management of chronic and recurrent pain in children and adolescents // Cochrane Database Syst Rev. 2015. Vol. 3, N 3. doi: 10.1002/14651858.CD011118.pub2

[75] Murray CS, Cohen A, Perkins T, et al. Morbidity in reflex sympathetic dystrophy. Arch Dis Child. 2000;82(3):231–233. doi: 10.1136/adc.82.3.231

[76] Murray C.S., Cohen A., Perkins T., et al. Morbidity in reflex sympathetic dystrophy // Arch Dis Child. 2000. Vol. 82, N 3. P. 231–233. doi: 10.1136/adc.82.3.231

[77] Wilder RT, Berde CB, Wolohan M, et al. Reflex sympathetic dystrophy in children. Clinical characteristics and follow-up of seventy patients. J Bone Joint Surg Am. 1992;74(6):910–919.

[78] Wilder R.T., Berde C.B., Wolohan M., et al. Reflex sympathetic dystrophy in children. Clinical characteristics and follow-up of seventy patients // J Bone Joint Surg Am. 1992. Vol. 74, N 6. P. 910–919.

[79] Badri T, Ben Jennet S, Fenniche S, et al. Reflex sympathetic dystrophy syndrome in a child. Acta Dermatovenerol Alp Pannonica Adriat. 2011;20(2):77–79.

[80] Badri T., Ben Jennet S., Fenniche S., et al. Reflex sympathetic dystrophy syndrome in a child // Acta Dermatovenerol Alp Pannonica Adriat. 2011. Vol. 20, N 2. P. 77–79.

[81] Kachko L, Efrat R, Ben Ami S, et al. Complex regional pain syndromes in children and adolescents. Pediatr Int. 2008;50(4):523–527. doi: 10.1111/j.1442-200X.2008.02625.x

[82] Kachko L., Efrat R., Ben Ami S., et al. Complex regional pain syndromes in children and adolescents // Pediatr Int. 2008. Vol. 50, N 4. P. 523–527. doi: 10.1111/j.1442-200X.2008.02625.x

[83] Martínez-Silvestrini JA, Micheo WF. Complex regional pain syndrome in pediatric sports: a case series of three young athletes. Bol Asoc Med P R. 2006;98(1):31–37.

[84] Martínez-Silvestrini J.A., Micheo W.F. Complex regional pain syndrome in pediatric sports: a case series of three young athletes // Bol Asoc Med P R. 2006. Vol. 98, N 1. P. 31–37.

[85] Kryzhanovsky SA, Otteva EN. Relief of neuropathic pain with gabapentin in patients with rheumatic diseases. Modern Problems of Rheumatology. 2007;(3):50–52. EDN: PEXRFZ

[86] Крыжановский С.А., Оттева Э.Н. Купирование невропатической боли габапентином у больных с ревматическими заболеваниями // Современные проблемы ревматологии. 2007. № 3. С. 50–52. EDN: PEXRFZ

[87] Ruggeri SB, Athreya BH, Doughty R, et al. Reflex sympathetic dystrophy in children. Clin Orthop Relat Res. 1982;(163):225–230.

[88] Ruggeri S.B., Athreya B.H., Doughty R., et al. Reflex sympathetic dystrophy in children // Clin Orthop Relat Res. 1982. N. 163. P. 225–230.

[89] Petje G, Radler C, Aigner N, et al. Treatment of reflex sympathetic dystrophy in children using a prostacyclin analog: preliminary results. Clin Orthop Relat Res. 2005;(433):178–182. doi: 10.1097/01.blo.0000151877.67386.45

[90] Petje G., Radler C., Aigner N., et al. Treatment of reflex sympathetic dystrophy in children using a prostacyclin analog: preliminary results // Clin Orthop Relat Res. 2005. N. 433. P. 178–182. doi: 10.1097/01.blo.0000151877.67386.45

[91] Brown S, Johnston B, Amaria K, et al. A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children. Scand J Pain. 2016;13:156–163. doi: 10.1016/j.sjpain.2016.05.039

[92] Brown S., Johnston B., Amaria K., et al. A randomized controlled trial of amitriptyline versus gabapentin for complex regional pain syndrome type I and neuropathic pain in children // Scand J Pain. 2016. Vol. 13. P. 156–163. doi: 10.1016/j.sjpain.2016.05.039

[93] Cossins L, Okell RW, Cameron H, et al. Treatment of complex regional pain syndrome in adults: a systematic review of randomized controlled trials published from June 2000 to February 2012. Eur J Pain. 2013;17(2):158–173. doi: 10.1002/j.1532-2149.2012.00217.x

[94] Cossins L., Okell R.W., Cameron H., et al. Treatment of complex regional pain syndrome in adults: a systematic review of randomized controlled trials published from June 2000 to February 2012 // Eur J Pain. 2013. Vol. 17, N 2. P. 158–173. doi: 10.1002/j.1532-2149.2012.00217.x

[95] Zotkin EG. Complex regional pain syndrome: possibilities of antiresorptive drugs. Effective pharmacotherapy. 2014;(53):64–68. EDN: TGWXBN

[96] Зоткин Е.Г. Комплексный региональный болевой синдром: возможности антирезорбтивных лекарственных средств // Эффективная фармакотерапия. 2014. № 53. С. 64–68. EDN: TGWXBN

[97] Kuznetsova NL, Yakovenko SP, Menzorova NV. Periarterial cryosympatodestraction in complex treatment CRBS (a Syndrome of Zudeka). Ural Medical Journal. 2010;(4):86–88. EDN: MVLNNJ

[98] Кузнецова Н.Л., Яковенко С.П., Мензорова Н.В. Периартериальная криосимпатодеструкция в комплексном лечении КРБС (синдрома Зудека) // Уральский медицинский журнал. 2010. № 4(69). С. 86–88. EDN: MVLNNJ

[99] Zernikow B, Wager J, Brehmer H, et al. Invasive treatments for complex regional pain syndrome in children and adolescents: a scoping review. Anesthesiology. 2015;122(3):699–707. doi: 10.1097/ALN.0000000000000573

[100] Zernikow B., Wager J., Brehmer H., et al. Invasive treatments for complex regional pain syndrome in children and adolescents: a scoping review // Anesthesiology. 2015. Vol. 122, N 3. P. 699–707. doi: 10.1097/ALN.0000000000000573

[101] Donado C, Lobo K, Velarde-Álvarez MF, et al. Continuous regional anesthesia and inpatient rehabilitation for pediatric complex regional pain syndrome. Reg Anesth Pain Med. 2017;42(4):527–534. doi: 10.1097/AAP.0000000000000593

[102] Donado C., Lobo K., Velarde-Álvarez M.F., et al. Continuous regional anesthesia and inpatient rehabilitation for pediatric complex regional pain syndrome // Reg Anesth Pain Med. 2017. Vol. 42, N 4. P. 527–534. doi: 10.1097/AAP.0000000000000593

[103] Sherry DD, Wallace CA, Kelley C, et al. Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy. Clin J Pain. 1999;15(3):218–223. doi: 10.1097/00002508-199909000-00009

[104] Sherry D.D., Wallace C.A., Kelley C., et al. Short- and long-term outcomes of children with complex regional pain syndrome type I treated with exercise therapy // Clin J Pain. 1999. Vol. 15, N 3. P. 218–223. doi: 10.1097/00002508-199909000-00009

[105] Brooke V, Janselewitz S. Outcomes of children with complex regional pain syndrome after intensive inpatient rehabilitation. PM R. 2012;4(5):349–354. doi: 10.1016/j.pmrj.2012.01.014

[106] Brooke V., Janselewitz S. Outcomes of children with complex regional pain syndrome after intensive inpatient rehabilitation // PM R. 2012. Vol. 4, N 5. P. 349–354. doi: 10.1016/j.pmrj.2012.01.014

[107] Takahashi Y, Tominaga T, Okawa K, et al. Recovery from acute pediatric complex regional pain syndrome type I after ankle sprain by early pharmacological and physical therapies in primary care: a case report. J Pain Res. 2018;11:2859–2866. doi: 10.2147/JPR.S164708

[108] Takahashi Y., Tominaga T., Okawa K., et al. Recovery from acute pediatric complex regional pain syndrome type I after ankle sprain by early pharmacological and physical therapies in primary care: a case report // J Pain Res. 2018. Vol. 11. P. 2859–2866. doi: 10.2147/JPR.S164708

[109] Berde CB, Lebel A. Complex regional pain syndromes in children and adolescents. Anesthesiology. 2005;102(2):252–255. doi: 10.1097/00000542-200502000-00003

[110] Berde C.B., Lebel A. Complex regional pain syndromes in children and adolescents // Anesthesiology. 2005. Vol. 102, N 2. P. 252–255. doi: 10.1097/00000542-200502000-00003

[111] Rastogi S, McCarthy KF. Complex pain in children and young people; part 2: management. BJA Educ. 2018;18(3):82–88. doi: 10.1016/j.bjae.2017.12.001

[112] Rastogi S., McCarthy K.F. Complex pain in children and young people; part 2: management // BJA Educ. 2018. Vol. 18, N 3. P. 82–88. doi: 10.1016/j.bjae.2017.12.001

[113] Kenis VM, Baindurashvili AG, Sapogovskiy AV, et al. Musculoskeletal injuries and pain in children involved in sports: a literature review. Pediatric Traumatology, Orthopaedics and Reconstructive Surgery. 2024;12(2):271–283. doi: 10.17816/PTORS633296

[114] Кенис В.М., Баиндурашвили А.Г., Сапоговский А.В., и др. Травмы опорно-двигательного аппарата и болевой синдром у детей, занимающихся спортом (обзор литературы) // Ортопедия, травматология и восстановительная хирургия детского возраста. 2024. Т. 12, № 2. C. 271–283. doi: 10.17816/PTORS633296

[115] WHO Guidelines on the pharmacological treatment of persisting pain in children with medical illnesses. Geneva: World Health Organization; 2012.

[116] WHO Guidelines on the pharmacological treatment of persisting pain in children with medical illnesses. Geneva: World Health Organization, 2012.

[117] Chang AK, Bijur PE, Esses D, et al. Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a randomized clinical trial. JAMA. 2017;318(17):1661–1667. doi: 10.1001/jama.2017.16190

[118] Chang A.K., Bijur P.E., Esses D., et al. Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a randomized clinical trial // JAMA. 2017.Vol. 318, N 17. P. 1661–1667. doi: 10.1001/jama.2017.16190

Funding

Dr. Reddy’s Laboratories LtdDr. Reddy’s Laboratories Ltd