Current concepts in the diagnosis and management of acute pain in children
Vladimir M. Kenis
Pediatric Traumatology, Orthopaedics and Reconstructive Surgery ›› 2024, Vol. 12 ›› Issue (1) : 139 -150.
Current concepts in the diagnosis and management of acute pain in children
BACKGROUND: In children, injuries are the focus of attention both for the increasing incidence and necessity of pain management, and pain can be indicate the severity of injuries or serious complications that worsens the treatment results. Despite the obvious problem, information available in the literature regarding the theoretical and practical aspects of acute pain in children is often contradictory and needs to be systematized.
AIM: To present current information about the epidemiology, physiology, diagnosis, and treatment of acute pain in children to pediatric orthopedic and trauma specialists.
MATERIALS AND METHODS: Selective analysis and narrative review of relevant studies analyzing the epidemiology, diagnosis, and management of acute pain in children were performed.
RESULTS: Although various pain assessment tools are available, the clinical assessment of acute pain in children remains challenging. The use of these tools depends on the child’s age, cognitive and communication skills, and pain location. The term oligoanalgesia has been used to describe inadequate pain relief in the emergency department. Oligoanalgesia in children has negative physiological and psychological effects, sometimes with long-term consequences, and may negatively affect their future pain experiences. Parents often underestimate their child’s pain level and have serious misunderstandings about how children express pain. The World Health Organization has developed recommendations for pain management in children. Ibuprofen and paracetamol are recommended as analgesics for mild-to-moderate pain in children aged >3 months. This choice considered extensive data on the effectiveness and safety.
CONCLUSIONS: Personalized management strategies utilizing biopsychosocial approach will ensure that children are treated comprehensively according to their unique pain status.
trauma / pain / children / oligoanalgesia / analgesics
| [1] |
Sterchen TH. Management of pain in the Emergency Department. ISRN Emergency Medicine. 2013;2013. doi: 10.1155/2013/583132 |
| [2] |
Sterchen T.H. Management of pain in the Emergency Department // ISRN Emergency Medicine. 2013. Vol. 2013. doi: 10.1155/2013/583132 |
| [3] |
Sterchen TH. Management of pain in the Emergency Department. ISRN Emergency Medicine. 2013;2013. doi: 10.1155/2013/583132 |
| [4] |
Krauss BS, Calligaris L, Green SM, et al. Current concepts in management of pain in children in the emergency department. Lancet. 2016;387(10013):83–92. doi: 10.1016/S0140-6736(14)61686-X |
| [5] |
Krauss B.S., Calligaris L., Green S.M., et al. Current concepts in management of pain in children in the emergency department // Lancet. 2016. Vol. 387, N. 10013. P. 83–92. doi: 10.1016/S0140-6736(14)61686-X |
| [6] |
Krauss BS, Calligaris L, Green SM, et al. Current concepts in management of pain in children in the emergency department. Lancet. 2016;387(10013):83–92. doi: 10.1016/S0140-6736(14)61686-X |
| [7] |
Selbst SM, Clark M. Analgesic use in the emergency department. Ann Emerg Med. 1990;19(9):1010–1013. doi: 10.1016/s0196-0644(05)82565-x |
| [8] |
Selbst S.M., Clark M. Analgesic use in the emergency department // Ann Emerg Med. 1990. Vol. 19, N. 9. P. 1010–1013. doi: 10.1016/s0196-0644(05)82565-x |
| [9] |
Selbst SM, Clark M. Analgesic use in the emergency department. Ann Emerg Med. 1990;19(9):1010–1013. doi: 10.1016/s0196-0644(05)82565-x |
| [10] |
Karreman E, Krause CS, Smith S. Children receive less analgesia in general ERs than adults: a retrospective study. JEMTAC. 2016;2016(1):1–5. doi: 10.5339/jemtac.2016.1 |
| [11] |
Karreman E., Krause C.S., Smith S. Children receive less analgesia in general ERs than adults: a retrospective study // JEMTAC. 2016. Vol. 2016, N. 1. P. 1–5. doi: 10.5339/jemtac.2016.1 |
| [12] |
Karreman E, Krause CS, Smith S. Children receive less analgesia in general ERs than adults: a retrospective study. JEMTAC. 2016;2016(1):1–5. doi: 10.5339/jemtac.2016.1 |
| [13] |
Drendel AL, Brousseau DC, Gorelick MH. Pain assessment for pediatric patients in the emergency department. Pediatrics. 2006;117(5):1511–1518. doi: 10.1542/peds.2005-2046 |
| [14] |
Drendel A.L., Brousseau D.C., Gorelick M.H. Pain assessment for pediatric patients in the emergency department // Pediatrics. 2006. Vol. 117, N. 5. P. 1511–1518. doi: 10.1542/peds.2005-2046 |
| [15] |
Drendel AL, Brousseau DC, Gorelick MH. Pain assessment for pediatric patients in the emergency department. Pediatrics. 2006;117(5):1511–1518. doi: 10.1542/peds.2005-2046 |
| [16] |
Albertyn R, Rode H, Millar AJ, et al. Challenges associated with paediatric pain management in Sub Saharan Africa. Int J Surg. 2009;7(2):91–93. doi: 10.1016/j.ijsu.2009.01.005 |
| [17] |
Albertyn R., Rode H., Millar A.J., et al. Challenges associated with pediatric pain management in Sub Saharan Africa // Int J Surg. 2009. Vol. 7, N. 2. P. 91–93. doi: 10.1016/j.ijsu.2009.01.005 |
| [18] |
Albertyn R, Rode H, Millar AJ, et al. Challenges associated with paediatric pain management in Sub Saharan Africa. Int J Surg. 2009;7(2):91–93. doi: 10.1016/j.ijsu.2009.01.005 |
| [19] |
Eccleston C, Fisher E, Howard RF, et al. Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission. Lancet Child Adolesc Health. 2021;5(1):47–87. doi: 10.1016/S2352-4642(20)30277-7 |
| [20] |
Eccleston C., Fisher E., Howard R.F., et al. Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission // Lancet Child Adolesc Health. 2021. Vol. 5, N. 1. P. 47–87. doi: 10.1016/S2352-4642(20)30277-7 |
| [21] |
Eccleston C, Fisher E, Howard RF, et al. Delivering transformative action in paediatric pain: a Lancet Child & Adolescent Health Commission. Lancet Child Adolesc Health. 2021;5(1):47–87. doi: 10.1016/S2352-4642(20)30277-7 |
| [22] |
American Academy of Pediatrics. Committee on Psychosocial Aspects of Child and Family Health; Task Force on Pain in Infants, Children, and Adolescents. The assessment and management of acute pain in infants, children, and adolescents. Pediatrics. 2001;108(3):793–797. doi: 10.1542/peds.108.3.793 |
| [23] |
American Academy of Pediatrics. Committee on psychosocial aspects of child and family health; task force on pain in infants, children, and adolescents. The assessment and management of acute pain in infants, children, and adolescents // Pediatrics. 2001. Vol. 108, N. 3. P. 793–797. doi: 10.1542/peds.108.3.793 |
| [24] |
American Academy of Pediatrics. Committee on Psychosocial Aspects of Child and Family Health; Task Force on Pain in Infants, Children, and Adolescents. The assessment and management of acute pain in infants, children, and adolescents. Pediatrics. 2001;108(3):793–797. doi: 10.1542/peds.108.3.793 |
| [25] |
Beltramini A, Milojevic K, Pateron D. Pain Assessment in newborns, infants, and children. Pediatr Ann. 2017;46(10):e387–e395. doi: 10.3928/19382359-20170921-03 |
| [26] |
Beltramini A., Milojevic K., Pateron D. Pain assessment in newborns, infants, and children // Pediatr Ann. 2017. Vol. 46, N. 10. P. e387–e395. doi: 10.3928/19382359-20170921-03 |
| [27] |
Beltramini A, Milojevic K, Pateron D. Pain Assessment in newborns, infants, and children. Pediatr Ann. 2017;46(10):e387–e395. doi: 10.3928/19382359-20170921-03 |
| [28] |
Walker SM. Pain in children: recent advances and ongoing challenges. Br J Anaesth. 2008;101(1):101–110. doi: 10.1093/bja/aen097 |
| [29] |
Walker S.M. Pain in children: recent advances and ongoing challenges // Br J Anaesth. 2008. Vol. 101, N. 1. P. 101–110. doi: 10.1093/bja/aen097 |
| [30] |
Walker SM. Pain in children: recent advances and ongoing challenges. Br J Anaesth. 2008;101(1):101–110. doi: 10.1093/bja/aen097 |
| [31] |
Lohman D, Schleifer R, Amon JJ. Access to pain treatment as a human right. BMC Med. 2010;8:8. doi: 10.1186/1741-7015-8-8 |
| [32] |
Lohman D., Schleifer R., Amon J.J. Access to pain treatment as a human right // BMC Med. 2010. Vol. 8. P. 8. doi: 10.1186/1741-7015-8-8 |
| [33] |
Lohman D, Schleifer R, Amon JJ. Access to pain treatment as a human right. BMC Med. 2010;8:8. doi: 10.1186/1741-7015-8-8 |
| [34] |
Craig KD, Grunau RV, Anand KJ, et al, editors. Neonatal pain perception and behavioral measurement. In: Pain research and clinical management. New York: Elsevier, 1993. P. 67–99. |
| [35] |
Craig K.D., Grunau R.V., Anand K.J., et al, editors. Neonatal pain perception and behavioral measurement. In: Pain research and clinical management. New York: Elsevier, 1993. P. 67–99. |
| [36] |
Craig KD, Grunau RV, Anand KJ, et al, editors. Neonatal pain perception and behavioral measurement. In: Pain research and clinical management. New York: Elsevier, 1993. P. 67–99. |
| [37] |
Herr K, Coyne PJ, Ely E, et al. Pain Assessment in the patient unable to self-report: clinical practice recommendations in support of the ASPMN 2019 position statement. Pain Manag Nurs. 2019;20(5):404–417. doi: 10.1016/j.pmn.2019.07.005 |
| [38] |
Herr K., Coyne P.J., Ely E., et al. Pain assessment in the patient unable to self-report: clinical practice recommendations in support of the ASPMN 2019 position statement // Pain Manag Nurs. 2019. Vol. 20, N. 5. P. 404–417. doi: 10.1016/j.pmn.2019.07.005 |
| [39] |
Herr K, Coyne PJ, Ely E, et al. Pain Assessment in the patient unable to self-report: clinical practice recommendations in support of the ASPMN 2019 position statement. Pain Manag Nurs. 2019;20(5):404–417. doi: 10.1016/j.pmn.2019.07.005 |
| [40] |
Izsak E, Moore JL, Stringfellow K, et al. Prehospital pain assessment in pediatric trauma. Prehosp Emerg Care. 2008;12(2);182–186. doi: 10.1080/10903120801907471 |
| [41] |
Izsak E., Moore J.L., Stringfellow K., et al. Prehospital pain assessment in pediatric trauma // Prehosp Emerg Care. 2008. Vol. 12, N. 2. P. 182–186. doi: 10.1080/10903120801907471 |
| [42] |
Izsak E, Moore JL, Stringfellow K, et al. Prehospital pain assessment in pediatric trauma. Prehosp Emerg Care. 2008;12(2);182–186. doi: 10.1080/10903120801907471 |
| [43] |
Herd DW, Babl FE, Gilhotra Y, et al; PREDICT group. Pain management practices in paediatric emergency departments in Australia and New Zealand: a clinical and organizational audit by National Health and Medical Research Council’s National Institute of Clinical Studies and Paediatric Research in Emergency Departments International Collaborative. Emerg Med Australas. 2009;21(3). doi: 10.1111/j.1742-6723.2009.01184.x |
| [44] |
Herd D.W., Babl F.E., Gilhotra Y., et al; PREDICT group. Pain management practices in paediatric emergency departments in Australia and New Zealand: a clinical and organizational audit by National Health and Medical Research Council’s National Institute of Clinical Studies and Paediatric Research in Emergency Departments International Collaborative // Emerg Med Australas. 2009. Vol. 21, N. 3. doi: 10.1111/j.1742-6723.2009.01184.x |
| [45] |
Herd DW, Babl FE, Gilhotra Y, et al; PREDICT group. Pain management practices in paediatric emergency departments in Australia and New Zealand: a clinical and organizational audit by National Health and Medical Research Council’s National Institute of Clinical Studies and Paediatric Research in Emergency Departments International Collaborative. Emerg Med Australas. 2009;21(3). doi: 10.1111/j.1742-6723.2009.01184.x |
| [46] |
Friedrichsdorf SJ, Postier A, Eull D, et al. Pain outcomes in a US children’s hospital: a prospective cross-sectional survey. Hosp Pediatr. 2015;5(1):18–26. doi: 10.1542/hpeds.2014-0084 |
| [47] |
Friedrichsdorf S.J., Postier A., Eull D., et al. Pain outcomes in a US children’s hospital: a prospective cross-sectional survey // Hosp Pediatr. 2015. Vol. 5, N. 1. P. 18–26. doi: 10.1542/hpeds.2014-0084 |
| [48] |
Friedrichsdorf SJ, Postier A, Eull D, et al. Pain outcomes in a US children’s hospital: a prospective cross-sectional survey. Hosp Pediatr. 2015;5(1):18–26. doi: 10.1542/hpeds.2014-0084 |
| [49] |
Wilson JE, Pendleton JM. Oligoanalgesia in the emergency department. Am J Emerg Med. 1989;7(6):620–623. doi: 10.1016/0735-6757(89)90286-6 |
| [50] |
Wilson J.E., Pendleton J.M. Oligoanalgesia in the emergency department // Am J Emerg Med. 1989. Vol. 7, N. 6. P. 620–623. doi: 10.1016/0735-6757(89)90286-6. |
| [51] |
Wilson JE, Pendleton JM. Oligoanalgesia in the emergency department. Am J Emerg Med. 1989;7(6):620–623. doi: 10.1016/0735-6757(89)90286-6 |
| [52] |
Wintgens A, Boileau B, Robaey P. Posttraumatic stress symptoms and medical procedures in children. Can J Psychiatry. 1997;42(6):611–616. doi: 10.1177/070674379704200607 |
| [53] |
Wintgens A., Boileau B., Robaey P. Posttraumatic stress symptoms and medical procedures in children // Can J Psychiatry. 1997. Vol. 42, N. 6. P. 611–616. doi: 10.1177/070674379704200607 |
| [54] |
Wintgens A, Boileau B, Robaey P. Posttraumatic stress symptoms and medical procedures in children. Can J Psychiatry. 1997;42(6):611–616. doi: 10.1177/070674379704200607 |
| [55] |
Taddio A, Katz J. The effects of early pain experience in neonates on pain responses in infancy and childhood. Paediatr Drugs. 2005;7(4);245–257. doi: 10.2165/00148581-200507040-00004 |
| [56] |
Taddio A., Katz J. The effects of early pain experience in neonates on pain responses in infancy and childhood // Paediatr Drugs. 2005. Vol. 7, N. 4. P. 245–257. doi: 10.2165/00148581-200507040-00004 |
| [57] |
Taddio A, Katz J. The effects of early pain experience in neonates on pain responses in infancy and childhood. Paediatr Drugs. 2005;7(4);245–257. doi: 10.2165/00148581-200507040-00004 |
| [58] |
Browne LR, Studnek JR, Shah MI, et al. Prehospital Opioid administration in the emergency care of injured children. Prehosp Emerg Care. 2016;20(1):59–65. doi: 10.3109/10903127.2015.1056897 |
| [59] |
Browne L.R., Studnek J.R., Shah M.I., et al. Prehospital opioid administration in the emergency care of injured children // Prehosp Emerg Care. 2016. Vol. 20, N. 1. P. 59–65. doi: 10.3109/10903127.2015.1056897 |
| [60] |
Browne LR, Studnek JR, Shah MI, et al. Prehospital Opioid administration in the emergency care of injured children. Prehosp Emerg Care. 2016;20(1):59–65. doi: 10.3109/10903127.2015.1056897 |
| [61] |
Singer AJ, Gulla J, Thode HC Jr. Parents and practitioners are poor judges of young children’s pain severity. Acad Emerg Med. 2002;9(6):609–612. doi: 10.1197/aemj.9.6.609 |
| [62] |
Singer A.J., Gulla J., Thode H.C. Parents and practitioners are poor judges of young children’s pain severity // Acad Emerg Med. 2002. Vol. 9, N. 6. P. 609–612. doi: 10.1197/aemj.9.6.609 |
| [63] |
Singer AJ, Gulla J, Thode HC Jr. Parents and practitioners are poor judges of young children’s pain severity. Acad Emerg Med. 2002;9(6):609–612. doi: 10.1197/aemj.9.6.609 |
| [64] |
Manocha S, Taneja N. Assessment of paediatric pain: a critical review. J Basic Clin Physiol Pharmacol. 2016;27(4):323–331. doi: 10.1515/jbcpp-2015-0041 |
| [65] |
Manocha S., Taneja N. Assessment of paediatric pain: a critical review // J Basic Clin Physiol Pharmacol. 2016. Vol. 27, N. 4. P. 323–331. doi: 10.1515/jbcpp-2015-0041 |
| [66] |
Manocha S, Taneja N. Assessment of paediatric pain: a critical review. J Basic Clin Physiol Pharmacol. 2016;27(4):323–331. doi: 10.1515/jbcpp-2015-0041 |
| [67] |
Wong C, Lau E, Palozzi L, et al. Pain management in children: part 1 – pain assessment tools and a brief review of nonpharmacological and pharmacological treatment options. Can Pharm J (Ott). 2012;145(5):222–225. doi: 10.3821/145.5.cpj222 |
| [68] |
Wong C., Lau E., Palozzi L., et al. Pain management in children: Part 1 - Pain assessment tools and a brief review of nonpharmacological and pharmacological treatment options // Can Pharm J (Ott). 2012. Vol. 145, N. 5. P. 222–225. doi: 10.3821/145.5.cpj222 |
| [69] |
Wong C, Lau E, Palozzi L, et al. Pain management in children: part 1 – pain assessment tools and a brief review of nonpharmacological and pharmacological treatment options. Can Pharm J (Ott). 2012;145(5):222–225. doi: 10.3821/145.5.cpj222 |
| [70] |
Peacock S, Patel S. Cultural influences on pain. Rev Pain. 2008;1(2):6–9. doi: 10.1177/204946370800100203 |
| [71] |
Peacock S, Patel S. Cultural influences on pain // Rev Pain. 2008. Vol. 1, N. 2. P. 6–9. doi: 10.1177/204946370800100203 |
| [72] |
Peacock S, Patel S. Cultural influences on pain. Rev Pain. 2008;1(2):6–9. doi: 10.1177/204946370800100203 |
| [73] |
Vetter TR, Bridgewater CL, Ascherman LI, et al. Patient versus parental perceptions about pain and disability in children and adolescents with a variety of chronic pain conditions. Pain Res Manag. 2014;19(1):7–14. doi: 10.1155/2014/736053 |
| [74] |
Vetter T.R., Bridgewater C.L., Ascherman L.I., et al. Patient versus parental perceptions about pain and disability in children and adolescents with a variety of chronic pain conditions // Pain Res Manag. 2014. Vol. 19, N. 1. P. 7–14. doi: 10.1155/2014/736053 |
| [75] |
Vetter TR, Bridgewater CL, Ascherman LI, et al. Patient versus parental perceptions about pain and disability in children and adolescents with a variety of chronic pain conditions. Pain Res Manag. 2014;19(1):7–14. doi: 10.1155/2014/736053 |
| [76] |
Foltin GL, Dayan P, Tunik M, et al. Priorities for pediatric prehospital research. Pediatr Emerg Care. 2010;26(10). doi: 10.1097/PEC.0b013e3181fc4088 |
| [77] |
Foltin G.L., Dayan P., Tunik M., et al. Priorities for pediatric prehospital research // Pediatr Emerg Care. 2010. Vol. 26, N. 10. doi: 10.1097/PEC.0b013e3181fc4088 |
| [78] |
Foltin GL, Dayan P, Tunik M, et al. Priorities for pediatric prehospital research. Pediatr Emerg Care. 2010;26(10). doi: 10.1097/PEC.0b013e3181fc4088 |
| [79] |
Conrad C, Soni P, Coorg V, et al. Prehospital analgesic administration by parents for pain relief in children. Pediatr Emerg Care. 2019;35(5). doi: 10.1097/PEC.0000000000001622 |
| [80] |
Conrad C., Soni P., Coorg V., et al. Prehospital analgesic administration by parents for pain relief in children // Pediatr Emerg Care. 2019. Vol. 35, N. 5. doi: 10.1097/PEC.0000000000001622 |
| [81] |
Conrad C, Soni P, Coorg V, et al. Prehospital analgesic administration by parents for pain relief in children. Pediatr Emerg Care. 2019;35(5). doi: 10.1097/PEC.0000000000001622 |
| [82] |
Twycross AM, Williams AM, Bolland RE, et al. Parental attitudes to children’s pain and analgesic drugs in the United Kingdom. J Child Health Care. 2015;19(3):402–411. doi: 10.1177/1367493513517305 |
| [83] |
Twycross A.M., Williams A.M., Bolland R.E., et al. Parental attitudes to children’s pain and analgesic drugs in the United Kingdom // J Child Health Care. 2015. Vol. 19, N. 3. P. 402–411. doi: 10.1177/1367493513517305 |
| [84] |
Twycross AM, Williams AM, Bolland RE, et al. Parental attitudes to children’s pain and analgesic drugs in the United Kingdom. J Child Health Care. 2015;19(3):402–411. doi: 10.1177/1367493513517305 |
| [85] |
Chambers CT, Reid GJ, Craig KD, et al. Agreement between child and parent reports of pain. Clin J Pain. 1998;14(4):336–342. doi: 10.1097/00002508-199812000-00011 |
| [86] |
Chambers C.T., Reid G.J., Craig K.D., et al. Agreement between child and parent reports of pain // Clin J Pain. 1998. Vol. 14, N. 4. P. 336–342. doi: 10.1097/00002508-199812000-00011 |
| [87] |
Chambers CT, Reid GJ, Craig KD, et al. Agreement between child and parent reports of pain. Clin J Pain. 1998;14(4):336–342. doi: 10.1097/00002508-199812000-00011 |
| [88] |
Spedding RL, Harley D, Dunn FJ, et al. Who gives pain relief to children? J Accid Emerg Med. 1999;16(4). doi: 10.1136/emj.16.4.261 |
| [89] |
Spedding R.L., Harley D., Dunn F.J., et al. Who gives pain relief to children? // J Accid Emerg Med. 1999. Vol. 16, N. 4. doi: 10.1136/emj.16.4.261 |
| [90] |
Spedding RL, Harley D, Dunn FJ, et al. Who gives pain relief to children? J Accid Emerg Med. 1999;16(4). doi: 10.1136/emj.16.4.261 |
| [91] |
Maimon MS, Marques L, Goldman RD. Parental administration of analgesic medication in children after a limb injury. Pediatr Emerg Care. 2007;23(4):223–226. doi: 10.1097/PEC.0b013e31803f5adc |
| [92] |
Maimon M.S., Marques L., Goldman R.D. Parental administration of analgesic medication in children after a limb injury // Pediatr Emerg Care. 2007. Vol. 23, N. 4. P. 223–226. doi: 10.1097/PEC.0b013e31803f5adc |
| [93] |
Maimon MS, Marques L, Goldman RD. Parental administration of analgesic medication in children after a limb injury. Pediatr Emerg Care. 2007;23(4):223–226. doi: 10.1097/PEC.0b013e31803f5adc |
| [94] |
Williams DM, Rindal KE, Cushman JT, et al. Barriers to and enablers for prehospital analgesia for pediatric patients. Prehosp Emerg Care. 2012;16(4):519–526. doi: 10.3109/10903127.2012.695436 |
| [95] |
Williams D.M., Rindal K.E., Cushman J.T., Shah M.N., et al. Barriers to and enablers for prehospital analgesia for pediatric patients // Prehosp Emerg Care. 2012. Vol. 16, N. 4. P. 519–526. doi: 10.3109/10903127.2012.695436 |
| [96] |
Williams DM, Rindal KE, Cushman JT, et al. Barriers to and enablers for prehospital analgesia for pediatric patients. Prehosp Emerg Care. 2012;16(4):519–526. doi: 10.3109/10903127.2012.695436 |
| [97] |
Murphy A, Barrett M, Cronin J, et al. A qualitative study of the barriers to prehospital management of acute pain in children. Emerg Med J. 2014;31(6):493–498. doi: 10.1136/emermed-2012-202166 |
| [98] |
Murphy A., Barrett M., Cronin J., et al. A qualitative study of the barriers to prehospital management of acute pain in children // Emerg Med J. 2014. Vol. 31, N. 6. P. 493–498. doi: 10.1136/emermed-2012-202166 |
| [99] |
Murphy A, Barrett M, Cronin J, et al. A qualitative study of the barriers to prehospital management of acute pain in children. Emerg Med J. 2014;31(6):493–498. doi: 10.1136/emermed-2012-202166 |
| [100] |
Murphy A, McCoy S, O’Reilly K, et al. A Prevalence and management study of acute pain in children attending emergency departments by ambulance. Prehosp Emerg Care. 2016;20(1):52–58. doi: 10.3109/10903127.2015.1037478 |
| [101] |
Murphy A., McCoy S., O’Reilly K., et al. A Prevalence and management study of acute pain in children attending emergency departments by ambulance // Prehosp Emerg Care. 2016. Vol. 20, N. 1. P. 52–58. doi: 10.3109/10903127.2015.1037478 |
| [102] |
Murphy A, McCoy S, O’Reilly K, et al. A Prevalence and management study of acute pain in children attending emergency departments by ambulance. Prehosp Emerg Care. 2016;20(1):52–58. doi: 10.3109/10903127.2015.1037478 |
| [103] |
Krechel SW, Bildner J. CRIES: a new neonatal postoperative pain measurement score. Initial testing of validity and reliability. Paediatr Anaesth. 1995;5(1):53–61. doi: 10.1111/j.1460-9592.1995.tb00242.x |
| [104] |
Krechel S.W., Bildner J. CRIES: a new neonatal postoperative pain measurement score. Initial testing of validity and reliability // Paediatr Anaesth. 1995. Vol. 5, N. 1. P. 53–61. doi: 10.1111/j.1460-9592.1995.tb00242.x |
| [105] |
Krechel SW, Bildner J. CRIES: a new neonatal postoperative pain measurement score. Initial testing of validity and reliability. Paediatr Anaesth. 1995;5(1):53–61. doi: 10.1111/j.1460-9592.1995.tb00242.x |
| [106] |
Ge X, Tao JR, Wang J, et al. Bayesian estimation on diagnostic performance of face, legs, activity, cry, and consolability and neonatal infant pain scale for infant pain assessment in the absence of a gold standard. Paediatr Anaesth. 2015;25(8):834–839. doi: 10.1111/pan.12664 |
| [107] |
Ge X., Tao J.R., Wang J., et al. Bayesian estimation on diagnostic performance of face, legs, activity, cry, and consolability and neonatal infant pain scale for infant pain assessment in the absence of a gold standard // Paediatr Anaesth. 2015. Vol. 25, N. 8. P. 834–839. doi: 10.1111/pan.12664 |
| [108] |
Ge X, Tao JR, Wang J, et al. Bayesian estimation on diagnostic performance of face, legs, activity, cry, and consolability and neonatal infant pain scale for infant pain assessment in the absence of a gold standard. Paediatr Anaesth. 2015;25(8):834–839. doi: 10.1111/pan.12664 |
| [109] |
Savedra M, Gibbons P, Tesler M, et al. How do children describe pain? A tentative assessment. Pain. 1982;14(2):95–104. doi: 10.1016/0304-3959(82)90091-4 |
| [110] |
Savedra M., Gibbons P., Tesler M., et al. How do children describe pain? A tentative assessment // Pain. 1982. Vol. 14, N. 2. P. 95–104. doi: 10.1016/0304-3959(82)90091-4 |
| [111] |
Savedra M, Gibbons P, Tesler M, et al. How do children describe pain? A tentative assessment. Pain. 1982;14(2):95–104. doi: 10.1016/0304-3959(82)90091-4 |
| [112] |
Fortuna RJ, Robbins BW, Caiola E, et al. Prescribing of controlled medications to adolescents and young adults in the United States. Pediatrics. 2010;126(6):1108–1116. doi: 10.1542/peds.2010-0791 |
| [113] |
Fortuna R.J., Robbins B.W., Caiola E., et al. Prescribing of controlled medications to adolescents and young adults in the United States // Pediatrics. 2010. Vol. 126, N. 6. P. 1108–1116. doi: 10.1542/peds.2010-0791 |
| [114] |
Fortuna RJ, Robbins BW, Caiola E, et al. Prescribing of controlled medications to adolescents and young adults in the United States. Pediatrics. 2010;126(6):1108–1116. doi: 10.1542/peds.2010-0791 |
| [115] |
Hewes HA, Dai M, Mann NC, et al. Prehospital pain management: disparity by age and race. Prehosp Emerg Care. 2018;22(2):189–197. doi: 10.1080/10903127.2017.1367444 |
| [116] |
Hewes H.A., Dai M., Mann N.C., et al. Prehospital pain management: disparity by age and race // Prehosp Emerg Care. 2018. Vol. 22, N. 2. P. 189–197. doi: 10.1080/10903127.2017.1367444 |
| [117] |
Hewes HA, Dai M, Mann NC, et al. Prehospital pain management: disparity by age and race. Prehosp Emerg Care. 2018;22(2):189–197. doi: 10.1080/10903127.2017.1367444 |
| [118] |
Srouji R, Ratnapalan S, Schneeweiss S. Pain in children: assessment and nonpharmacological management. Int J Pediatr. 2010;2010. doi: 10.1155/2010/474838 |
| [119] |
Srouji R., Ratnapalan S., Schneeweiss S. Pain in children: assessment and nonpharmacological management // Int J Pediatr. 2010. Vol. 2010. doi: 10.1155/2010/474838 |
| [120] |
Srouji R, Ratnapalan S, Schneeweiss S. Pain in children: assessment and nonpharmacological management. Int J Pediatr. 2010;2010. doi: 10.1155/2010/474838 |
| [121] |
Leahy S, Kennedy RM, Hesselgrave J, et al. On the front lines: lessons learned in implementing multidisciplinary peripheral venous access pain-management programs in pediatric hospitals. Pediatrics. 2008;122(Suppl 3):S161–S170. doi: 10.1542/peds.2008-1055i |
| [122] |
Leahy S., Kennedy R.M., Hesselgrave J., et al. On the front lines: lessons learned in implementing multidisciplinary peripheral venous access pain-management programs in pediatric hospitals // Pediatrics. 2008. Vol. 122, Suppl. 3. P. S161–S170. doi: 10.1542/peds.2008-1055i |
| [123] |
Leahy S, Kennedy RM, Hesselgrave J, et al. On the front lines: lessons learned in implementing multidisciplinary peripheral venous access pain-management programs in pediatric hospitals. Pediatrics. 2008;122(Suppl 3):S161–S170. doi: 10.1542/peds.2008-1055i |
| [124] |
Craig KD, Lilley CM, Gilbert CA. Social barriers to optimal pain management in infants and children. Clin J Pain. 1996;12(3):232–242. doi: 10.1097/00002508-199609000-00011 |
| [125] |
Craig K.D., Lilley C.M., Gilbert C.A. Social barriers to optimal pain management in infants and children // Clin J Pain. 1996. Vol. 12, N. 3. P. 232–242. doi: 10.1097/00002508-199609000-00011 |
| [126] |
Craig KD, Lilley CM, Gilbert CA. Social barriers to optimal pain management in infants and children. Clin J Pain. 1996;12(3):232–242. doi: 10.1097/00002508-199609000-00011 |
| [127] |
Krauss BS, Krauss BA, Green SM. Videos in clinical medicine. Managing procedural anxiety in children. N Engl J Med. 2016;374(16):e19. doi: 10.1056/NEJMvcm1411127 |
| [128] |
Krauss B.S., Krauss B.A., Green S.M. Videos in clinical medicine. Managing procedural anxiety in children // N Engl J Med. 2016. Vol. 374, N. 16. doi: 10.1056/NEJMvcm1411127 |
| [129] |
Krauss BS, Krauss BA, Green SM. Videos in clinical medicine. Managing procedural anxiety in children. N Engl J Med. 2016;374(16):e19. doi: 10.1056/NEJMvcm1411127 |
| [130] |
WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses. Geneva: World Health Organization; 2012. |
| [131] |
WHO Guidelines on the pharmacological treatment of persisting pain in children with medical illnesses. Geneva: World Health Organization; 2012. |
| [132] |
WHO guidelines on the pharmacological treatment of persisting pain in children with medical illnesses. Geneva: World Health Organization; 2012. |
| [133] |
rosminzdrav.ru [Internet]. State register of medicines. Available from: https://grls.rosminzdrav.ru. |
| [134] |
rosminzdrav.ru [Internet]. Государственный реестр лекарственных средств. Режим доступа: https://grls.rosminzdrav.ru. Дата обращения: 15.02.2024. |
| [135] |
rosminzdrav.ru [Internet]. State register of medicines. Available from: https://grls.rosminzdrav.ru. |
| [136] |
Lutz M. Metamizole (dipyrone) and the liver: a review of the literature. J Clin Pharmacol. 2019;59(11):1433–1442. doi: 10.1002/jcph.1512 |
| [137] |
Lutz M. Metamizole (dipyrone) and the liver: a review of the literature // J Clin Pharmacol. 2019. Vol. 59, N. 11. P. 1433–1442. doi: 10.1002/jcph.1512 |
| [138] |
Lutz M. Metamizole (dipyrone) and the liver: a review of the literature. J Clin Pharmacol. 2019;59(11):1433–1442. doi: 10.1002/jcph.1512 |
| [139] |
Saygitov R. Efficacy of ibuprofen in treatment of pain in children: systematic review of randomized controlled studies. Current Pediatrics. 2010;9(6):52–62. EDN: NELVCN |
| [140] |
Сайгитов Р. Эффективность ибупрофена в терапии боли у детей: систематический обзор результатов рандомизированных контролируемых исследований // Вопросы современной педиатрии. 2010. Т. 9, № 6. С. 52–62. EDN: NELVCN |
| [141] |
Saygitov R. Efficacy of ibuprofen in treatment of pain in children: systematic review of randomized controlled studies. Current Pediatrics. 2010;9(6):52–62. EDN: NELVCN |
| [142] |
Ali S, Manaloor R, Johnson DW, Rosychuk RJ, et al; Pediatric Emergency Research Canada. An observational cohort study comparing ibuprofen and oxycodone in children with fractures. PLoS One. 2021;16(9). doi: 10.1371/journal.pone.0257021 |
| [143] |
Ali S., Manaloor R., Johnson D.W., et al; Pediatric Emergency Research Canada. An observational cohort study comparing ibuprofen and oxycodone in children with fractures // PLoS One. 2021. Vol. 16, N. 9. doi: 10.1371/journal.pone.0257021 |
| [144] |
Ali S, Manaloor R, Johnson DW, Rosychuk RJ, et al; Pediatric Emergency Research Canada. An observational cohort study comparing ibuprofen and oxycodone in children with fractures. PLoS One. 2021;16(9). doi: 10.1371/journal.pone.0257021 |
| [145] |
Poonai N, Bhullar G, Lin K, et al. Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial. CMAJ. 2014;186(18):1358–1363. doi: 10.1503/cmaj.140907 |
| [146] |
Poonai N., Bhullar G., Lin K., et al. Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial // CMAJ. 2014. Vol. 186, N. 18. P. 1358–1363. doi: 10.1503/cmaj.140907 |
| [147] |
Poonai N, Bhullar G, Lin K, et al. Oral administration of morphine versus ibuprofen to manage postfracture pain in children: a randomized trial. CMAJ. 2014;186(18):1358–1363. doi: 10.1503/cmaj.140907 |
| [148] |
Jelinek GA. Ketorolac versus morphine for severe pain. Ketorolac is more effective, cheaper, and has fewer side effects. BMJ. 2000;321(7271):1236–1237. doi: 10.1136/bmj.321.7271.1236 |
| [149] |
Jelinek G.A. Ketorolac versus morphine for severe pain. Ketorolac is more effective, cheaper, and has fewer side effects // BMJ. 2000. Vol. 321, N. 7271. P. 1236–1237. doi: 10.1136/bmj.321.7271.1236 |
| [150] |
Jelinek GA. Ketorolac versus morphine for severe pain. Ketorolac is more effective, cheaper, and has fewer side effects. BMJ. 2000;321(7271):1236–1237. doi: 10.1136/bmj.321.7271.1236 |
| [151] |
Chang AK, Bijur PE, Esses D, et al. Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a randomized clinical trial. JAMA. 2017;318(17):1661–1667. doi: 10.1001/jama.2017.16190 |
| [152] |
Chang A.K., Bijur P.E., Esses D., et al. Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a randomized clinical trial // JAMA. 2017. Vol. 318, N. 17. P. 1661–1667. doi: 10.1001/jama.2017.16190 |
| [153] |
Chang AK, Bijur PE, Esses D, et al. Effect of a single dose of oral opioid and nonopioid analgesics on acute extremity pain in the emergency department: a randomized clinical trial. JAMA. 2017;318(17):1661–1667. doi: 10.1001/jama.2017.16190 |
| [154] |
Bailey E, Worthington HV, van Wijk A, et al. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database Syst Rev. doi: 10.1002/14651858.CD004624.pub2 |
| [155] |
Bailey E., Worthington H.V., van Wijk A., et al. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth // Cochrane Database Syst Rev. 2013. N. 12. doi: 10.1002/14651858.CD004624.pub2 |
| [156] |
Bailey E, Worthington HV, van Wijk A, et al. Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database Syst Rev. doi: 10.1002/14651858.CD004624.pub2 |
| [157] |
Smith MD, Spiller HA, Casavant MJ, et al. Out-of-hospital medication errors among young children in the United States, 2002–2012. Pediatrics. 2014;134(5):867–876. doi: 10.1542/peds.2014-0309 |
| [158] |
Smith M.D., Spiller H.A., Casavant M.J., et al. Out-of-hospital medication errors among young children in the United States, 2002–2012 // Pediatrics. 2014. Vol. 134, N. 5. P. 867–876. doi: 10.1542/peds.2014-0309 |
| [159] |
Smith MD, Spiller HA, Casavant MJ, et al. Out-of-hospital medication errors among young children in the United States, 2002–2012. Pediatrics. 2014;134(5):867–876. doi: 10.1542/peds.2014-0309 |
| [160] |
Geppe NA, Kolosova NG, Malakhov AB, et al. Fever management in children with acute respiratory tract infections. Doctor.Ru. 2021;20(10):6–11. EDN: JTZLTU doi: 10.31550/1727-2378-2021-20-10-6-11 |
| [161] |
Геппе Н.А., Колосова Н.Г., Малахов А.Б., и др. Терапия лихорадки у детей при острых инфекциях дыхательных путей // Доктор.Ру. 2021. Т. 20, № 10. С. 6–11. EDN: JTZLTU doi: 10.31550/1727-2378-2021-20-10-6-11 |
| [162] |
Geppe NA, Kolosova NG, Malakhov AB, et al. Fever management in children with acute respiratory tract infections. Doctor.Ru. 2021;20(10):6–11. EDN: JTZLTU doi: 10.31550/1727-2378-2021-20-10-6-11 |
| [163] |
Danilov AB, Danilov AB. Physiological and psychological model and chronic pain. Modern therapy in psychiatry and neurology. 2013;(1):30–36. (in Russ.) EDN: PXUFGF |
| [164] |
Данилов А.Б., Данилов А.Б. Биопсихосоциокультурная модель и хроническая боль // Современная терапия в психиатрии и неврологии. 2013. № 1. С. 30–36. EDN: PXUFGF |
| [165] |
Danilov AB, Danilov AB. Physiological and psychological model and chronic pain. Modern therapy in psychiatry and neurology. 2013;(1):30–36. (in Russ.) EDN: PXUFGF |
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