The effect of overweight and obesity on the severity of manifestations of chronic nonbacterial prostatitis with an inflammatory component

Abstract

BACKGROUND: Chronic prostatitis is one of the most common urological diseases of young and middle-aged men. The variety of pathogenetic mechanisms and clinical manifestations, the tendency to recurrence necessitates the search for new methods of examination and monitoring of this disease.

AIM: To identify the characteristics of the clinical manifestations of chronic non-bacterial prostatitis with an inflammatory component in men of the first period of adulthood, depending on the body mass index.

MATERIALS AND METHODS: A comprehensive urological examination was carried out on 150 men with CNVC in the first period of adulthood, aged 22 to 35 years. All patients were assessed for hormonal status, as well as anthropometric parameters.

RESULTS: Men with normal body mass index had milder clinical symptoms of prostatitis compared with overweight and obese patients. The results of laboratory studies demonstrated a more pronounced inflammatory process and dysfunction of the prostate in patients with a higher body mass index. Analysis of hormonal status revealed high levels of total and free testosterone and low levels of estradiol in men with normal body mass index. The content of sex hormone-binding globulin was significantly lower in obese patients. Overweight and obese men also had larger prostate volume according to TRUS.

CONCLUSIONS: More severe manifestations of prostatitis are associated with an increase in body mass index.

Keywords

chronic prostatitis / body mass index / somatometry

References

[1] Menshikova LV, Babanskaya EB. Age and sex epidemiology of obesity. Obesity and metabolism. 2018;15(2):17–22. EDN: XUNGRN doi: 10.14341/omet8782

[2] Меньшикова Л.В., Бабанская Е.Б. Половозрастная эпидемиология ожирения // Ожирение и метаболизм. 2018. Т. 15, № 2. С. 17–22. EDN: XUNGRN doi: 10.14341/omet8782

[3] Razina AO, Runenko SD, Achkasov EE. Obesity: current global and Russian trends. Annals of the Russian Academy of Medical Sciences. 2016;71(2):154–159. EDN: VYQBYN doi: 10.15690/vramn655

[4] Разина А.О., Руненко С.Д., Ачкасов Е.Е. Проблема ожирения: современные тенденции в России и в мире // Вестник РАМН. 2016. Т. 71, № 2. С. 154–159. EDN: VYQBYN doi: 10.15690/vramn655

[5] NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. Lancet. 2016;387(10026):1377–1396. doi: 10.1016/S0140-6736(16)30054-X

[6] NCD Risk Factor Collaboration (NCD-RisC). Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants // Lancet. 2016. Vol. 387, N. 10026. P. 1377–1396. doi: 10.1016/S0140-6736(16)30054-X

[7] National Health and Medical Research Council. Clinical practice guidelines for the management of overweight and obesity in adults, adolescents and children: draft clinical practice guidelines for primary healthcare professionals. Canberra: NHMRC, 2013. 229 p.

[8] Cabrera-Fuentes HA, Alba-Alba C, Aragones J, et al. Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside. Basic Res Cardiol. 2016;111(1):7. doi: 10.1007/s00395-015-0527-0

[9] Cabrera-Fuentes H.A., Alba-Alba C., Aragones J., et al. Meeting report from the 2nd International Symposium on New Frontiers in Cardiovascular Research. Protecting the cardiovascular system from ischemia: between bench and bedside // Basic Res Cardiol. 2016. Vol. 111, N. 1. ID 7. doi: 10.1007/s00395-015-0527-0

[10] Bondarenko VM, Pimanov SI, Makarenko EV, Bondarenko EF. Metabolically healthy obesity: epidemiology, criteria and pathogenetic mechanisms. Vitebsk medical journal. 2023;22(3):19–28. EDN: AWVIAL doi: 10.22263/2312-4156.2023.3.19

[11] Бондаренко В.М., Пиманов С.И., Макаренко Е.В., Бондаренко Е.Ф. Метаболически здоровое ожирение: эпидемиология, критерии и патогенетические механизмы // Вестник Витебского государственного медицинского университета. 2023. Т. 22, № 3. С. 19–28. EDN: AWVIAL doi: 10.22263/2312-4156.2023.3.19

[12] Bozhedomov VA, Semenov AV, Konyshev AV, et al. Reproductive function in men with chronic prostatitis: clinical, disease history and microbiological risk aspects. Urologiia. 2015;(1):70–78. EDN: TWQFTN

[13] Божедомов В.А., Семенов А.В., Пацановская Г.М., и др. Репродуктивная функция мужчин при хроническом простатите: клинико-анамнестические и микробиологические аспекты // Урология. 2015. № 1. С. 70–78. EDN: TWQFTN

[14] Apolihin OI, Komarova VA, Nikushina AA, Sivkov AV. Prostate diseases in the Russian Federation: statistical data for 2008–2017. Experimental and clinical urology. 2019;(2):4–13. EDN: DHXMJP doi: 10.29188/2222-8543-2019-11-2-4-12

[15] Аполихин О.И., Комарова В.А., Никушина А.А., Сивков А.В. Болезни предстательной железы в Российской Федерации: статистические данные 2008–2017 гг. // Экспериментальная и клиническая урология. 2019. № 2. C. 4–13. EDN: DHXMJP doi: 10.29188/2222-8543-2019-11-2-4-12

[16] Loran OB, Segal AS. The chronic prostatitis symptom summative assessment system (CPS-CP). Urologiia. 2001;(5):16–19. EDN: SLUUYL (In Russ.)

[17] Лоран О.Б., Сегал А.С. Система суммарной оценки симптомов при хроническом простатите (СОС-ХП) // Урология. 2001. № 5. С. 16–19. EDN: SLUUYL

[18] Vasil’chenko GS, Botneva IL, Vinnik YuYu, et al. General sexopathology: a guide for physicians. Moscow: Meditsina Publ., 2005. 512 p. (In Russ.)

[19] Васильченко Г.С., Ботнева И.Л., Винник Ю.Ю., и др. Общая сексопатология: руководство для врачей. Москва: Медицина, 2005. 512 с.

[20] Kivimäki M, Strandberg T, Pentti J, et al. Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study. Lancet Diabetes Endocrinol. 2022;10(4):253–263. doi: 10.1016/S2213-8587(22)00033-X

[21] Kivimäki M., Strandberg T., Pentti J., et al. Body-mass index and risk of obesity-related complex multimorbidity: an observational multicohort study // Lancet Diabetes Endocrinol. 2022. Vol. 10, N. 4. P. 253–263. doi: 10.1016/S2213-8587(22)00033-X

[22] Leisegang K, Sengupta P, Agarwal A, Henkel R. Obesity and male infertility: Mechanisms and management. Andrologia. 2021;53(1): e13617. doi: 10.1111/and.13617

[23] Leisegang K., Sengupta P., Agarwal A., Henkel R. Obesity and male infertility: Mechanisms and management // Andrologia. 2021. Vol. 53, N. 1. ID e13617. doi: 10.1111/and.13617

[24] Lutov YuV, Novikova EG, Selyatitskaya VG. The role of abdominal obesity in the development of prostate diseases. International Journal of Experiential Education. 2014;(1–2):73–77. EDN: RTEVAN

[25] Лутов Ю.В., Новикова Е.Г., Селятицкая В.Г. Роль абдоминального ожирения в развитии заболеваний предстательной железы // Международный журнал экспериментального образования. 2014. № 1–2. С. 73–77. EDN: RTEVAN

[26] Vinnik YuYu, Prokhorenkov VI. Evaluation of pathogenetic factors of chronic prostatitis development. Russian journal of skin and venereal disease. 2013;(1):61–65. EDN: PWLHNB

[27] Винник Ю.Ю., Прохореноков В.И. Оценка патогенетических факторов развития хронического простатита // Российский журнал кожных и венерических болезней. 2013. № 1. С. 61–65. EDN: PWLHNB

[28] He Q, Wang Z, Liu G, et al. Metabolic syndrome, inflammation and lower urinary tract symptoms: Possible translational links. Prostate Cancer Prostatic Dis. 2016;19:7–13. doi: 10.1038/pcan.2015.43

[29] He Q., Wang Z., Liu G., et al. Metabolic syndrome, inflammation and lower urinary tract symptoms: Possible translational links // Prostate Cancer Prostatic Dis. 2016. Vol. 19. P. 7–13. doi: 10.1038/pcan.2015.43

[30] Pozdnyak AO, Fatkhullin AG. Features of androgen metabolism in common diseases in men of reproductive age. University Therapeutic Journal. 2021;3(1):49–57. EDN: FKBBWT

[31] Поздняк А.О., Фатхуллин А.Г. Особенности метаболизма андрогенов при распространенных заболеваниях у мужчин репродуктивного возраста // University Therapeutic Journal. 2021. Т. 3, № 1. С. 49–57. EDN: FKBBWT

[32] Pirola GM, Verdacchi T, Rosadi S, et al. Chronic prostatitis: current treatment options. Res Rep Urol. 2019;11:165–174. doi: 10.2147/RRU.S194679

[33] Pirola G.M., Verdacchi T., Rosadi S., et al. Chronic prostatitis: current treatment options // Res Rep Urol. 2019. Vol. 11. P. 165–174. doi: 10.2147/RRU.S194679

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