THE PROBLEM OF HEART TRANSPLANT REJECTION AND WAYS OF OPTIMIZING THE ASSESSMENT OF ENDOMYOCARDIAL BIOPSY RESULTS

T V Stavenchuk; E D Kosmachova; I A Shelestova; A A Slavinsky; E A Terman; A A Verevkin; L A Medvedeva; K O Barbuhatty; Z G Tatarintseva; V A Porchanov

doi:10.17816/clinpract8328-33

Journal of Clinical Practice ›› 2017, Vol. 8 ›› Issue (3) : 28 -33. DOI: 10.17816/clinpract8328-33

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THE PROBLEM OF HEART TRANSPLANT REJECTION AND WAYS OF OPTIMIZING THE ASSESSMENT OF ENDOMYOCARDIAL BIOPSY RESULTS

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Abstract

The following article describes tactics of recipient management when a rejection episode of a heart transplant is being suspected. We have discovered some new figures to assess biopsy samples through computerised morphometric study, which can both improve and clarify biopsy results. CD3+ (T-cells) and CD 68+ (macrophages) figures make it possible to determine the extent of transplant rejection in accordance with the International Society for Heart and Lung Transplantation diagnostic criteria (sensitivity 91%, specificity 91%).

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computerised morphometric study / endomyocardial biopsy / heart transplant rejection

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T V Stavenchuk, E D Kosmachova, I A Shelestova, A A Slavinsky, E A Terman, A A Verevkin, L A Medvedeva, K O Barbuhatty, Z G Tatarintseva, V A Porchanov. THE PROBLEM OF HEART TRANSPLANT REJECTION AND WAYS OF OPTIMIZING THE ASSESSMENT OF ENDOMYOCARDIAL BIOPSY RESULTS. Journal of Clinical Practice, 2017, 8(3): 28-33 DOI:10.17816/clinpract8328-33

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References

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[1]	Пациент с трансплантированным сердцем: руководство для врачей по ведению пациентов, перенесших трансплантацию сердца / С. В. Готье, А. О. Шевченко, В. Н. Попцов. М. - Тверь: Триада, 2014: 144с.

[2]	Шумаков В.И. Трансплантология. 2-е издание: учебное пособие. Манн, Иванов и Фербер, 2006. 544с.

[3]	Costanzo M.R. [et al.] The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients J. Heart Lung Transplant. 2010. Vol. 29, N 8. P. 914-956.

[4]	Bocchi E.A. [et al.] Immunohistochemical Quantification of inflammatory Cells in Endomyocardial Biopsy fragments after heart transplantation: a new potentional method to improve the diagnosis of rejection after heart transplantation. Transplant. Proc. 2014. Vol. 46, N 5. P. 1489-1496.

[5]	Nair V., Butany J. Heart transplant biopsies: interpretation and significance. J Сlin Pathol. 2010. Vol. 63, N 1. P. 12-20.

[6]	Куприянова А.Г. [и др.] Ускоренное гуморальное отторжение аллотрансплантата сердца. Вестн. трансплантол и искусств органов. 2011. Т. 13, № 2. С. 70-77.

[7]	Ильинский, И. М. [и др.] Гистологическая характеристика эффекта QUILTY Вестн. трансплантол и искусств органов. 2015. Т. 17, № 3. С. 14-23.

[8]	Шиллер Н.Б. Эхокардиография пересаженного сердца / Н. Б. Шиллер, Ю. С. Соболь, Р. Я. Абдуллаев // Междунар. мед. журн. 2006. Т. 12, № 4. С. 103-108.

[9]	Clemmensen T.S. [et. al.] Changes in longitudinal myocardial deformation during acute cardiac rejection: the clinical role of two-dimensional speckle-tracking echocardiography J Am Soc Echocardiogr. 2015. Vol. 28, N 3. P. 330-339.

[10]	Ciliberto, G. R. [et al.] Acute rejection after heart transplantation: noninvasive echocardiographic evaluation.J Am Coll Cardiol.1994. Vol. 23 №5. Р. 1156-1161.

RIGHTS & PERMISSIONS

Stavenchuk T.V., Kosmachova E.D., Shelestova I.A., Slavinsky A.A., Terman E.A., Verevkin A.A., Medvedeva L.A., Barbuhatty K.O., Tatarintseva Z.G., Porchanov V.A.