ANALYSIS OF GENE METHYLATION SHOX2, TGFBR1, MIR-375 IN DIFFERENT TYPES OF LUNG CANCER
D S Khodyrev , N S Kulagina , O I Brovkina , V E Pokrovsky , M G Gordiev , A S Кelekhsaeva , A G Nikitin , A V Averyanov
Journal of Clinical Practice ›› 2016, Vol. 7 ›› Issue (4) : 27 -33.
ANALYSIS OF GENE METHYLATION SHOX2, TGFBR1, MIR-375 IN DIFFERENT TYPES OF LUNG CANCER
In the 21st century is an acute problem to find effective and inexpensive methods for the early detection of lung cancer. Patients suspected of having a malignant disease of the lungs, generally undergo clinical studies such as CT scans of the chest and bronchoscopy. The latter is mainly used to confirm the diagnosis. However, even when the signs, symptoms and radiological findings indicate that clinical diagnosis of malignant lung disease is evident, additional invasive procedures for obtaining the biological material suitable for the final confirmation of the presence of malignant cells. Currently, there is a clear understanding of the need to find biomarkers able to detect pre-clinical stage of cancer cells using minimally invasive procedures. In this paper, for the DNA of patients with different types of lung cancer samples, with a view to a better understanding of the causes of lung cancer pathology gene methylation analysis was conducted for SHOX2, TGFBR1 and MIR-375.
SHOX2 / TGFBR1 / MIR-375 / Lung cancer / SHOX2 / TGFBR1 / MIR-375 / DNA methylation / microRNA
Khodyrev D.S., Kulagina N.S., Brovkina O.I., Pokrovsky V.E., Gordiev M.G., Кelekhsaeva A.S., Nikitin A.G., Averyanov A.V.
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