DIFFICULTIES OF DIFFERENTIAL DIAGNOSIS BETWEEN ATYPICAL LEIOMYOMA AND LEIOMYOSARCOMA OF THE UTERINE BODY
E A Kogan , M A Solomakhina , S I Askolskaya , Yu V Popov , A V Kozachenko , N M Fayzullina , T V Kekeeva , A A Shikeeva
Journal of Clinical Practice ›› 2016, Vol. 7 ›› Issue (1) : 70 -74.
DIFFICULTIES OF DIFFERENTIAL DIAGNOSIS BETWEEN ATYPICAL LEIOMYOMA AND LEIOMYOSARCOMA OF THE UTERINE BODY
Leiomyoma of the uterus is a benign hormone-dependent tumors in women.The incidence of LM among gynecological diseases is 25 to 50%, according to different authors. In reproductive-aged women its frequency is about 30%. WHO recommends to allocate leiomyoma, which in russian literature often referred to as a simple or ordinary leiomyoma, and its histologic variants (cellular, mitotic activity, epithelioid, myxoid, atypical leiomyoma and lipoleyomioma etc.).We performed clinical and morphological analysis of atypical uterine leiomyoma in 44-year-old woman. Immunohistochemical study detected positive reaction to smooth muscle actin, dismin, progesterone receptors, N-caldesmon. Adverse reactions to c-kit, ER keratins. Proliferation index by Ki-67 does not exceed 10%. At the molecular genetic research in the studied loci, the microsatellite instability and loss of heterozygosity, characteristic of the LMS, were not revealed.
c-kit / ki-67 / uterine leiomyoma / leiomyosarcoma / c-kit / ki-67
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Kogan E.A., Solomakhina M.A., Askolskaya S.I., Popov Y.V., Kozachenko A.V., Fayzullina N.M., Kekeeva T.V., Shikeeva A.A.
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