EXPERIMENTAL AND THEORETICAL STUDY OF ANTIMICROBIAL PROPERTIES OF CATIONIC PHTHALOCYANINES
I B Kovalenko , M G Strakhovskaya , S Yu Kovalenko , T V Galochkina , A V Averyanov , D V Zlenko , A M Nesterenko
Journal of Clinical Practice ›› 2015, Vol. 6 ›› Issue (2) : 66 -72.
EXPERIMENTAL AND THEORETICAL STUDY OF ANTIMICROBIAL PROPERTIES OF CATIONIC PHTHALOCYANINES
The article is devoted to the work of the laboratory of molecular modeling and bioinformatics of Federal Scientific and Clinical Center of FMBA of Russia. The problems of photodynamic inactivation of bacteria, examining electrostatic interaction of the cationic phthalocyanines with lipopolysaccharides - endotoxins of gram-negative bacteria, the sorption properties of heterogeneous cationic phthalocyanines against lipopolysaccharides are discussed. Computer simulation of the outer membrane of Gram-negative bacteria and phthalocyanine molecules is also discussed.
photodynamic inactivation / photosensitizer / reactive oxygen species / endotoxin - lipopolysaccharide / sepsis / sorbent / phthalocyanines / electrostatic interaction / computer model
Kovalenko I.B., Strakhovskaya M.G., Kovalenko S.Y., Galochkina T.V., Averyanov A.V., Zlenko D.V., Nesterenko A.M.
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