PROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY
M G Strakhovskaya , N S Belenikina , V V Nikitina , S Yu Kovalenko , I B Kovalenko , A V Averyanov , A B Rubin , T V Galochkina
Journal of Clinical Practice ›› 2013, Vol. 4 ›› Issue (1) : 25 -30.
PROMISING PHOTOSENSITIZER FOR ANTIMICROBIAL PHOTODYNAMIC THERAPY
A photosensitizer from polycationic metallophthalocyanines class is shown to have a high antimicrobial activity and a wide antimicrobial spectrum. It is established that the effective pho- todynamic inactivation of bacteria in the presence of photosensitizer of polycationic nature is determined by its electrostatic binding to negatively charged structures of bacterial cell walls. The usage of antimicrobial photodynamic therapy in medical practice is discussed from the point of view of the obtained results.
photosensitizer / reactive oxygen species / antimicrobial photodynamic therapy
| [1] |
Jori G., Brown S.B. Photosensitized inactivation of microorganisms. Photochem Photobiol Sci 2004; 3: 403-405. |
| [2] |
Nitzan Y., Gutterman M., Malik Z., et al. Inactivation of gram-negative bacteria by photosensitized porphyrins. Photochem Photobiol 1992; 55: 89-96. |
| [3] |
Raetz C.R., Ulevitch R.J., Wright S.D., et al. Gram-negative endotoxin: an extraordinary lipid with profound effects on eukaryotic signal transduction. FASEB J 1991; 5: 2652-60. |
| [4] |
Raetz C.R., Reynolds C.M., Trent M.S. et al. Lipid A modification systems in gram-negative bacteria. Annu Rev Biochem 2007; 76: 295-329. |
| [5] |
Hamblin M.R., Hasan T. Photodynamic therapy: a new antimicrobial approach to infectious disease? Photochem Photobiol Sci 2004; 3: 436-450. |
| [6] |
Макаров Д.А., Кузнецова Н.А., Страховская М.Г. и др. Поликатионные фталоцианины цинка и алюминия: синтез, влияние степени замещения на физико-химические свойства и фотодинамическую активность в водной среде. Журнал физической химии 2009; 6: 1183-1190. |
| [7] |
Kuznetsova N.A., Yuzhakova O.A., Strakhovskaya M.G., et al. New heterogeneous photosensitizers with phthalocyanine molecules covalently linked to aminopropyl silica gel. Journal of Porphyrins and Phthalocyanines 2011; 15: 718-726. |
Strakhovskaya M.G., Belenikina N.S., Nikitina V.V., Kovalenko S.Y., Kovalenko I.B., Averyanov A.V., Rubin A.B., Galochkina T.V.
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