EFFICIENCY OF PLASMASORBTION IN PATIENTS WITH ENDOTHELIAL DYSFUNCTION WITH CHRONIC KIDNEY DISEASE
A N Fedoseev , A S Kudriakova , V V Smirnov , T A Krutova , K V Ovsiannikov
Journal of Clinical Practice ›› 2013, Vol. 4 ›› Issue (1) : 19 -24.
EFFICIENCY OF PLASMASORBTION IN PATIENTS WITH ENDOTHELIAL DYSFUNCTION WITH CHRONIC KIDNEY DISEASE
The influence of plasmasorbtion on vasodilatation activity of blood vessels in 85 patients with chronic kidney disease compared with therapy by inhibitors of angiothensine-converting enzyme was studied. It is proved the efficiency of plasmasorbtion on normalization of endothelinum-dependent vasodilatation in 74% patients and by lowing concentration of endothelinum-1 on 59±7,9% by the end of first month of trial. We noticed that therapy with inhibitors of angiohtensine-converting enzyme allowed to reach that level of endothelinum-1 only by the 6th month of trial. Normalization of endothelium functions can afford to decrease the level of daily proteinuria (p<0,05) and to increase the speed of glomerular filtration within 1 year by 7,6±1,5 ml/min in patients with I-II stage of chronic kidney disease and by 2,2±0,6 ml/min in patients with III-IV stage of chronic kidney disease.
endothelial dysfunction / chronic kidney disease / plasmasorbtion
Fedoseev A.N., Kudriakova A.S., Smirnov V.V., Krutova T.A., Ovsiannikov K.V.
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