EFFICIENCY OF PLASMASORBTION IN PATIENTS WITH ENDOTHELIAL DYSFUNCTION WITH CHRONIC KIDNEY DISEASE

A N Fedoseev; A S Kudriakova; V V Smirnov; T A Krutova; K V Ovsiannikov

doi:10.17816/clinpract4119-24

Journal of Clinical Practice ›› 2013, Vol. 4 ›› Issue (1) : 19 -24. DOI: 10.17816/clinpract4119-24

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EFFICIENCY OF PLASMASORBTION IN PATIENTS WITH ENDOTHELIAL DYSFUNCTION WITH CHRONIC KIDNEY DISEASE

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Abstract

The influence of plasmasorbtion on vasodilatation activity of blood vessels in 85 patients with chronic kidney disease compared with therapy by inhibitors of angiothensine-converting enzyme was studied. It is proved the efficiency of plasmasorbtion on normalization of endothelinum-dependent vasodilatation in 74% patients and by lowing concentration of endothelinum-1 on 59±7,9% by the end of first month of trial. We noticed that therapy with inhibitors of angiohtensine-converting enzyme allowed to reach that level of endothelinum-1 only by the 6th month of trial. Normalization of endothelium functions can afford to decrease the level of daily proteinuria (p<0,05) and to increase the speed of glomerular filtration within 1 year by 7,6±1,5 ml/min in patients with I-II stage of chronic kidney disease and by 2,2±0,6 ml/min in patients with III-IV stage of chronic kidney disease.

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endothelial dysfunction / chronic kidney disease / plasmasorbtion

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A N Fedoseev,A S Kudriakova,V V Smirnov,T A Krutova,K V Ovsiannikov. EFFICIENCY OF PLASMASORBTION IN PATIENTS WITH ENDOTHELIAL DYSFUNCTION WITH CHRONIC KIDNEY DISEASE. Journal of Clinical Practice, 2013, 4(1): 19-24 DOI:10.17816/clinpract4119-24