The nervous system damage in COVID-19

Vladimir V. Belopasov , Yassine Yachou , Ekaterina M. Samoilova , Vladimir P. Baklaushev

Journal of Clinical Practice ›› 2020, Vol. 11 ›› Issue (2) : 60 -80.

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Journal of Clinical Practice ›› 2020, Vol. 11 ›› Issue (2) : 60 -80. DOI: 10.17816/clinpract34851
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The nervous system damage in COVID-19

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Abstract

Based on the available publications, the article systematizes the data on the forms of damage to the central nervous system in СOVID-19 patients. We discuss the diagnostic approaches (laboratory, instrumental and radiological) and the therapeutic tactics for different nosological forms from cranial mononeuropathies to acute inflammatory Guillain-Barré polyneuropathy and severe damage to the brain and spinal cord with acute hemorrhagic necrotizing encephalopathy and myelopathies. Pathogenetically, neurological disorders in COVID-19 can be caused by a “cytokine storm”, hypoxemia, homeostasis disorders (encephalopathy of critical illness), neurotropic and neurovirulence features of SARS-CoV-2 (isolated damage to the cranial nerves, focal and diffuse lesions of the central nervous system), and mixed effects of these factors. COVID-19 affects the course of chronic neurological diseases, especially related with neuroimmune disorders. All of the above determines the need for a multidisciplinary approach to the treatment of COVID-19 and its complications with the mandatory participation of a neurologist.

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new coronavirus disease / COVID-19 / SARS-CoV-2 / viral damage of brain and spinal cord / viral meningoencephalitis / critical illness encephalopathy

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Vladimir V. Belopasov, Yassine Yachou, Ekaterina M. Samoilova, Vladimir P. Baklaushev. The nervous system damage in COVID-19. Journal of Clinical Practice, 2020, 11(2): 60-80 DOI:10.17816/clinpract34851

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Российский Фонд Фундаментальных ИсследованийRussian Science Foundation For Basic Reserch(19-29-01090)

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Belopasov V.V., Yachou Y., Samoilova E.M., Baklaushev V.P.

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