CLINICAL AND PATHOGENETIC ASPECTS OF ISCHAEMIC HEART DISEASE COMPLICATED BY CHTONIC HEART FAILURE

Abstract

Objectives: To investigate genetic and neurohumoral determinants of chronic heart failure (CHF) development and progression in ischaemic heart disease (IHD) patients. Methods: Serum neurohormone level analysis (angiotensin II, aldosterone, endotheline1, NTproBNP, TNFα) and genotyping (genes encoding ACE, angiotensinogen, and type1 angiotensin II receptors ) were implemented in 100 patients Results: Activation of endotheline and NTproBNP is characteristic of early CHF stages while decompensation of chronic heart failure shows elevation in aldosterone and TNFα . Structural polymorphism of renineangiotensine system genes is not significant in CHF development and progression in IHD patients.

Keywords

neurohormones / genetic polymorphism / reninangeotensin system / chronic heart failure

References

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RIGHTS & PERMISSIONS

Dorofeeva N.P., Pleskachev S.A., Shlyk S.V., Tchigaeva E.V., TherAnanyanz E.A., Mashtalova O.G., Koulikova I.E., Pleskachev A.S., Todorov S.S.