CLINICAL AND PATHOGENETIC ASPECTS OF ISCHAEMIC HEART DISEASE COMPLICATED BY CHTONIC HEART FAILURE

N P Dorofeeva; S A Pleskachev; S V Shlyk; E V Tchigaeva; E A TherAnanyanz; O G Mashtalova; I E Koulikova; A S Pleskachev; S S Todorov

doi:10.17816/clinpract2167-73

Journal of Clinical Practice ›› 2011, Vol. 2 ›› Issue (1) : 67 -73. DOI: 10.17816/clinpract2167-73

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CLINICAL AND PATHOGENETIC ASPECTS OF ISCHAEMIC HEART DISEASE COMPLICATED BY CHTONIC HEART FAILURE

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Abstract

Objectives: To investigate genetic and neurohumoral determinants of chronic heart failure (CHF) development and progression in ischaemic heart disease (IHD) patients. Methods: Serum neurohormone level analysis (angiotensin II, aldosterone, endotheline1, NTproBNP, TNFα) and genotyping (genes encoding ACE, angiotensinogen, and type1 angiotensin II receptors ) were implemented in 100 patients Results: Activation of endotheline and NTproBNP is characteristic of early CHF stages while decompensation of chronic heart failure shows elevation in aldosterone and TNFα . Structural polymorphism of renineangiotensine system genes is not significant in CHF development and progression in IHD patients.

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neurohormones / genetic polymorphism / reninangeotensin system / chronic heart failure

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N P Dorofeeva, S A Pleskachev, S V Shlyk, E V Tchigaeva, E A TherAnanyanz, O G Mashtalova, I E Koulikova, A S Pleskachev, S S Todorov. CLINICAL AND PATHOGENETIC ASPECTS OF ISCHAEMIC HEART DISEASE COMPLICATED BY CHTONIC HEART FAILURE. Journal of Clinical Practice, 2011, 2(1): 67-73 DOI:10.17816/clinpract2167-73