SYNTHETIC INOSINE ANALOGS IN TREATMENT OF CIN IIII
S A Levakov , A G Kedrova , E V Kozhurina , N S Wanke
Journal of Clinical Practice ›› 2010, Vol. 1 ›› Issue (3) : 43 -51.
SYNTHETIC INOSINE ANALOGS IN TREATMENT OF CIN IIII
Genes products of human papillomavirus (HPV) have been identified in more then 99,7% of cervical carcinomas. Several factors may be associated with higher rates of surgical treatment failure, including highgrade CIN, large lesion size, satellite HPVrelated lesions, involved margin, persistent HPV infection. Several pharmaceutical analogs of inosine have been using about 40 years to treat broad spectrum of viral infections. Clinical and experimental studies concerning efficacy and molecular mechanism of Inosine pranobeх are characterized this product as a safe and natural immune stimulating agent with beneficial results in patients with HPV. The purpose of the study is to evaluate the effect and toxicity of the antivirus therapy of Inosine pranobeх in the complex treatment of HPV infected patients affected CIN, CC in situ and recurrence of CIN in HPVpositive women after loop conization. Surgery with the antivirus therapy of Inosine pranobeх exhibited a protective effect on the recurrence of any CIN. Inosine pranobeх is characterized as a natural immune stimulating agent without pleiotropic effects of cytokines. Our data and global clinical studies have confirmed the safety and efficacy in the treatment of CIN Inosine pranobex.
immunomodulators / cervicalintraepithelial neoplasia / inosine / Inosine Pranobex / Groprinosin / Isoprinosine
Levakov S.A., Kedrova A.G., Kozhurina E.V., Wanke N.S.
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