PROPOFOL-INDUCED METABOLIC DISTRESS SYNDROME
V. V. Lazarev , S. A. Daryin , G. P. Brusov , L. E. Tsypin , T. G. Popova
Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care ›› 2018, Vol. 8 ›› Issue (2) : 65 -69.
PROPOFOL-INDUCED METABOLIC DISTRESS SYNDROME
Introduction. The obtained experience of using propofol under clinical conditions and in experimental studies discover the mechanism of a negative drug effect at the level of mitochondrial enzymes which is currently treated as the propofol infusion syndrome.
Purpose. To demonstrate the cases of creatine phosphokinase level variation during the intraoperative pediatric use of propofol in anesthesia.
Materials and methods. Three cases of intraoperative use of propofol in 2–17‑years-old patients with different dosages and dose schedules.
Results. The level of creatine phosphokinase was increased 9–44 times within 2–5 days of postoperative period without any significant disturbances or with insignificant changes in the levels of transaminase and lactic dehydrogenase (LDG).
Conclusion. Propofol-based variation in the cellular metabolism proven today rather corresponds to the term ‘propofol-induced metabolic distress syndrome’. It can be manifested both at the level of clinical symptoms and subclinically, without any evident clinical signs with short-term transient variations of laboratory parameters only (acid-base balance (ABB), transaminase, LDG and CPK).
propofol / propofol infusion syndrome / propofol induced metabolic distress syndrome / children / mitochondria / cytochrome oxidase
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Lazarev V.V., Daryin S.A., Brusov G.P., Tsypin L.E., Popova T.G.
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