Systemic inflammatory response in infants with craniostenosis sedated with propofol

Abstract

AIM: This study aimed to investigate the possible effect of intravenous anesthesia (sedation) with propofol on the levels of several cytokines (interleukin [IL]-6, IL-8, IL-10, and tumor necrosis factors-α) and S100B protein in the blood plasma of children aged <1 year with craniostenosis.

MATERIALS AND METHODS: Twenty patients aged 1–12 months diagnosed with non-syndromic forms of craniosynostosis, who underwent magnetic resonance imaging (MRI) of the brain under propofol sedation, were classified according to ASA I-II class. Peripheral blood sampling was performed before and after the drug administration, followed by laboratory analysis.

RESULTS: A significant increase was found in the serum level of IL-6 (p = 0.004) when intravenous sedation with propofol was used for 29 ± 4.93 min.

CONCLUSION: Short exposure of children aged <1 year with craniostenosis to hypnotic propofol during brain MRI significantly increased the level of the pro-inflammatory cytokine IL-6 in the blood plasma.

Keywords

sedation / propofol / pediatrics / cytokines / S100B / neuroapoptosis / magnetic resonance imaging / craniostenosis

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