PILOT VALIDATION OF EARLY PREDICTORS FOR NEONATAL SEPSIS
R. Kh. Gizatullin , P. I. Mironov , A. U. Lekmanov
Russian Journal of Pediatric Surgery, Anesthesia and Intensive Care ›› 2018, Vol. 8 ›› Issue (4) : 58 -65.
PILOT VALIDATION OF EARLY PREDICTORS FOR NEONATAL SEPSIS
Purpose: pilot development of the system estimating the risk for sepsis in newborns and determining its discrimination power.
Methods. Design: a retrospective observational single-center study. 124 newborns with sepsis are included; 34 of them died. Kullback’s measure was used to estimate the information value of the examined clinical and laboratory variables. Disease outcome (whether survived or dead) was the response function. The discrimination power was determined using ROC-analysis.
Results. The information value of the examined clinical and laboratory variables in the newborns was analyzed as related to the risk for sepsis. Early neonatal sepsis predictors include platelet count, total protein content, body mass and neutrophil count. Discrimination power of the mentioned predictors was calculated.
Result. Determination of the risk for sepsis in a newborn based on the estimation of platelet count, neutrophil count, total protein and body mass is of moderate value.
newborns / sepsis / predictors / information value
| [1] |
1. Singer M., Deutschman C.S., Seymour C.W., Shankar Hari M., Annane D., Bauer M., Bellomo R., Bernard G.R., Chiche J.D., Coopersmith C.M., Hotchkiss R.S., Levy M.M., Marshall J.C., Martin G.S., Opal S.M., Rubenfeld G.D., van der Poll T., Vincent J.L., Angus D.C. The Third International Consensus Defnitions for Sepsis and Septic Shock (Sepsis-3). JAMA 2016; 315 (8): 801–10 doi:10.1001/jama.2016.0287 |
| [2] |
2. Freund Y., Lemachatti N., Krastinova E., Van Laer M., Claessens Y.E., Avondo A., Occelli C., Feral-Pierssens A. L., Truchot J., Ortega M., Carneiro B., Pernet J., Claret P.G., Dami F., Bloom B., Riou B., Beaune S. Prognostic accuracy of Sepsis-3 criteria for in-hospital mortality among patients with suspected infection presenting to the emergency department. JAMA. 2017;317:301–8. |
| [3] |
3. Song Jae-Uk, Kyung S. Ch., Park Н.К., Sung Ryul Shim, Jonghoo Lee. Performance of the quick Sequential (sepsisrelated) Organ Failure Assessment score as a prognostic tool in infected patients outside the intensive care unit: a systematic review and meta-analysis. Critical Care 2018;22:28 https://doi.org/10.1186/s13054–018–1952-x |
| [4] |
4. Rudd K.E., Seymour C.W., Aluisio A.R., Augustin M.E., Bagenda D.S., Beane A., Byiringiro J.C., Chang C.H., Colas L.N., Day NPJ, De Silva A.P., Dondorp A.M., Dünser M.W., Faiz M.A., Grant D.S., Haniffa R., Van Hao N., Kennedy J.N., Levine A.C.., Limmathurotsakul D., Mohanty S., Nosten F., Papali A., Patterson A.J., Schieffelin J.S., Shaffer J.G., Thuy D.B., Thwaites C.L., Urayeneza O., White N.J., West T.E., Angus D.C. Association of the Quick Sequential (Sepsis-Related) Organ Failure Assessment (qSOFA) Score With Excess Hospital Mortality in Adults With Suspected Infection in Low- and Middle-Income Countries. JAMA. 2018; 319 (21):2202–11. DOI: 10.1001/jama.2018.6229 |
| [5] |
5. Schlapbach L.J., Straney L., Bellomo R., MacLaren G., Pilcher D. Prognostic accuracy of age-adapted SOFA, SIRS, PELOD-2, and qSOFA for in-hospital mortality among children with suspected infection admitted to the intensive care unit. Intensive Care Med. 2018; 44 (2): 179–88 DOI: 10.1007/s00134–017–5021–8 |
| [6] |
6. Peters C., Srinivas M., Rollin B., Niranjan K., Matthias G. Mortality Risk Using a Pediatric Quick Sequential (SepsisRelated) Organ Failure Assessment Varies With Vital Sign Thresholds. Pediatric Critical Care Medicine. 2018; 19 (8) e394 – e402. DOI: 10.1097/PCC.0000000000001598 |
| [7] |
7. Gerdes J.S. Diagnosis and management of bacterial infections in the neonate. Pediatr Clin North Am. 2004;51:939–59, viii-ix. DOI: 10.1016/j.pcl.2004.03.009 |
| [8] |
8. Bonadio W.A., Hennes H., Smith D., Rufng R., Melzer-Lange M., Lye P., Isaacman D. Reliability of observation variables in distinguishing infectious outcome of febrile young infants. Pediatr Infect Dis J. 1993;12:111–4 |
| [9] |
9. Иванов Д.О., Шабалов Н.П., Петренко Ю.В. Неонатальый сепсис.Опыт построения гипотезы. //Детская медицина Северо-запада.– 2012.– № 3.– с. 37–45 |
| [10] |
10. Иванов Д.О., Петренко Ю.В., Курзина Е.А., Петрова Н.А. Показатели клинического анализа крови у новорожденных, заболевших неонатальным сепсисом./ Бюллютень Федерального центра сердца, крови и эндокринологии им. В. А. АЛМАЗОВА.– 2012.– № 3.– с. 41–52 |
| [11] |
11. Кульбак С. Теория информативности и статистика.– М.: Наука, 1967.– с. 408 |
| [12] |
12. Laham J.L., Breheny P.J., Gardner B.M., Bada H. Procalciotoni to predict bacterial coinfection in infants with acue bronchiolitis A preliminary Anallysis Pediatric Emergency Care. 2014; 30: 11–5 DOI: 10.1097/PEC.0000000000000026. |
| [13] |
13. Meem M., Modak J.K., Mortuza R., Morshed M., Islam M.S., Saha S.K. Biomarkers for diagnosis of neonatal infections: A systematic analysis of their potential as a point-of-care diagnostics. J. of Global health. 2011; 1: 201–9 |
| [14] |
14. Zielinska-Borkowska U., Skirecki T., Zlotorowicz M., Czarnocka B. Procalcitonin in early onset ventilator-associated pneumonia. J. Hosp Infect. 2012; 81:92–7. DOI: https://doi.org/10.1016/j.jhin.2012.02.011 |
| [15] |
15. Астафьева М.Н., Руднов В.А., Кулабухов В.В., Багин В.А., Зубарева Н.А., Трибулёв М.А., Мухачева С.Ю. Использование шкалы qSOFAв диагностике сепсиса. Результаты Российского многоцентрового исследования РИСЭС. // Вестник анестезиологии и реаниматологии.– 2018.– т. 15.– № 4.– с. 14–22 https://doi.org/10.21292/2078–5658–2018–15–4–14–22 |
Gizatullin R.K., Mironov P.I., Lekmanov A.U.
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