Hydraulic tests of a new centrifugal pump with shrouded impeller for extracorporeal membrane oxygenation systems

Abstract

BACKGROUND: The problem of creating a centrifugal pump for extracorporeal membrane oxygenation systems (hereinafter referred to as ECMO), optimal in terms of its hydraulic characteristics and its effect on blood, still remains relevant. This work is a continuation of the authors’ previous research in this area and contains the results of hydraulic tests of prototypes of the new ECMO pump with the closed impeller on water and water-glycerin mixtures, which imitate the viscous properties of blood.

AIM: Determination and comparison the head-flow characteristics of the new ECMO pump with the closed impeller when operating on water and water-glycerin mixtures.

METHODS: A series of hydraulic tests of pump prototypes, manufactured using different technologies, was carried out. Three liquids were considered as the working fluid during the tests: process water at a temperature of 20 °C and two water-glycerin mixtures at a temperature of 20 °C with different ratios of water and glycerin (to obtain different viscosities).

RESULTS: The pressure characteristics of pump prototypes, manufactured using different technologies, were obtained using water and water-glycerin mixtures. Tests with use of water showed that the deviation of the calculated and experimental characteristics from each other does not exceed 4%; the deviation of the characteristics of prototypes, manufactured using different technologies, is on average 1.5%. Tests with use of a water-glycerin mixture showed that the deviation of the characteristics from those obtained with use of water is on average 6%, the largest deviation is observed at the edges of the characteristics. In addition, when tested with use of a water-glycerin mixture, the deviation of the characteristics of prototypes, manufactures using different technologies, is about 4%, which is higher than when tested with use of water.

CONCLUSION: The results obtained allow us to conclude that the numerical model used in previous work can reliably predict the performance of the pump with use of water. The pressure characteristics of water and a water-glycerin mixture differ from each other, which must be taken into account when assessing the operating parameters of such pumps. The influence of manufacturing technology on the performance characteristics of the pump is higher when it operates with use of a liquid more viscous than water, e.g. on a water-glycerin mixture.

Keywords

Centrifugal pump / 3D printing / milling / casting in silicone molds / hydraulic testing

References

[1] Salfity HV, Bottiger B, Cooter M, et al. Transfusion Requirements during Lung Transplantation: Elective VA ECMO vs. Off-Pump. The Journal of Heart and Lung Transplantation. 2021;40(4). doi: 10.1016/j.healun.2021.01.932

[2] Salfity H.V., Bottiger B., Cooter M., et al. Transfusion Requirements during Lung Transplantation: Elective VA ECMO vs. Off-Pump // The Journal of Heart and Lung Transplantation. 2021. Vol. 40, N. 4, doi: 10.1016/j.healun.2021.01.932

[3] Echieh C, Hooker R. Extracorporeal Membrane Oxygenation (ECMO) Use in Heart Transplantation. Intechopen; 2024. doi: 10.5772/intechopen.114126

[4] Echieh C., Hooker R. Extracorporeal Membrane Oxygenation (ECMO) Use in Heart Transplantation. Intechopen, 2024. doi: 10.5772/intechopen.114126

[5] Crowley J. ECMO in the Trauma Patient: A Practical Approach. In: Degiannis, E., Doll, D., Velmahos, G.C. (eds) Penetrating Trauma. Cham: Springer; 2023. doi: 10.1007/978-3-031-47006-6_14

[6] Crowley J. ECMO in the Trauma Patient: A Practical Approach. In: Degiannis, E., Doll, D., Velmahos, G.C. (eds) Penetrating Trauma. Cham: Springer, 2023. doi: 10.1007/978-3-031-47006-6_14

[7] Alibrahim O, Heard CMB. ECMO for the Neonate. In: Lerman, J. (eds) Neonatal Anesthesia. Cham: Springer; 2023. doi: 10.1007/978-3-031-25358-4_12

[8] Alibrahim O., Heard C.M.B. ECMO for the Neonate. In: Lerman, J. (eds) Neonatal Anesthesia. Cham: Springer, 2023. doi: 10.1007/978-3-031-25358-4_12

[9] Burgos CM, Frenckner B, Broman LM, et al. Crossing-borders: Experience with International ECMO transports. Research Square; 2024. doi: 10.21203/rs.3.rs-3826309/v1

[10] Burgos C.M., Frenckner B., Broman L.M., et al. Crossing-borders: Experience with International ECMO transports. Research Square, 2024. doi: 10.21203/rs.3.rs-3826309/v1

[11] Qiu Y, Hilmi I. The applications of ECMO in liver transplant recipients. Transplant Rev (Orlando). 2024;38(1). doi: 10.1016/j.trre.2023.100816

[12] Qiu Y., Hilmi I. The applications of ECMO in liver transplant recipients // Transplant Rev (Orlando). 2024. Vol. 38, N. 1. doi: 10.1016/j.trre.2023.100816

[13] Bartlett RH. The Story of ECMO. Anesthesiology. 2024;140: 578–584 doi: 10.1097/ALN.0000000000004843

[14] Bartlett R.H. The Story of ECMO // Anesthesiology. 2024. Vol. 140. P. 578–584 doi: 10.1097/ALN.0000000000004843

[15] Patel K, Ündar A. Centrifugal Pump Generates Superior Hemodynamic Performance Compared to a new Diagonal Blood Pump in Neonatal and Pediatric ECMO Circuits. World Journal for Pediatric and Congenital Heart Surgery. 2022;13(2):235–241. doi: 10.1177/21501351211057426

[16] Patel K., Ündar A. Centrifugal Pump Generates Superior Hemodynamic Performance Compared to a new Diagonal Blood Pump in Neonatal and Pediatric ECMO Circuits // World Journal for Pediatric and Congenital Heart Surgery. 2022. Vol. 13, N. 2. P. 235–241. doi: 10.1177/21501351211057426

[17] Wang S, Moroi M, Kunselman A, et al. Evaluation of centrifugal blood pumps in term of hemodynamic performance using simulated neonatal and pediatric ECMO circuits. Artificial Organs. 2019;44(1). P. 16–27. doi: 10.1111/aor.13436

[18] Wang S., Moroi M., Kunselman A., et al. Evaluation of centrifugal blood pumps in term of hemodynamic performance using simulated neonatal and pediatric ECMO circuits // Artificial Organs. 2019. Vol. 44, N. 1. P. 16–27. doi: 10.1111/aor.13436

[19] Han D, Zhang J, He Ge, et al. Computational fluid dynamics-based design and in vitro characterization of a novel pediatric pump-lung. Artif. Organs. 2024;48:130–140. doi: 10.1111/aor.14665

[20] Han D., Zhang J., He Ge, et al. Computational fluid dynamics-based design and in vitro characterization of a novel pediatric pump-lung // Artif. Organs. 2024. Vol. 48. P. 130–140. doi: 10.1111/aor.14665

[21] Li P, Mei X, Ge W, et al. A comprehensive comparison of the invitro hemocompatibility of extracorporeal centrifugal blood pumps. Front. Physiol. 2023;14. doi: 10.3389/fphys.2023.1136545

[22] Li P., Mei X., Ge W., et al. A comprehensive comparison of the in vitro hemocompatibility of extracorporeal centrifugal blood pumps // Front. Physiol. 2023. Vol. 14. doi: 10.3389/fphys.2023.1136545

[23] Gao S, Wang W, Qi J, et al. Safety and Efficacy of a Novel Centrifugal Pump and Driving Devices of the OASSIST ECMO System: A Preclinical Evaluation in the Ovine Model. Frontiers in Medicine. 2021;8. doi: 10.3389/fmed.2021.712205

[24] Gao S., Wang W., Qi J., et al. Safety and Efficacy of a Novel Centrifugal Pump and Driving Devices of the OASSIST ECMO System: A Preclinical Evaluation in the Ovine Model // Frontiers in Medicine. 2021. N. 8. doi: 10.3389/fmed.2021.712205

[25] Wu G, Xu Ch, Liu X, et al. Hydraulics and in vitro hemolysis test of a maglev implantable ventricular assist device. Journal of Mechanics in Medicine and Biology. 2017;17. doi: 10.1142/S0219519417400231

[26] Wu G., Xu Ch., Liu X., et al. Hydraulics and in vitro hemolysis test of a maglev implantable ventricular assist device // Journal of Mechanics in Medicine and Biology. 2017. Vol. 17. doi: 10.1142/S0219519417400231

[27] Huang B, Guo M, Lu B, et al. Geometric Optimization of an Extracorporeal Centrifugal Blood Pump with an Unshrouded Impeller Concerning Both Hydraulic Performance and Shear Stress. Processes. 2021;9(7). doi: 10.3390/pr9071211

[28] Huang B., Guo M., Lu B., et al. Geometric Optimization of an Extracorporeal Centrifugal Blood Pump with an Unshrouded Impeller Concerning Both Hydraulic Performance and Shear Stress // Processes. 2021. Vol. 9, N. 7. doi: 10.3390/pr9071211

[29] Wu P, Huo J, Dai W, et al. On the Optimization of a Centrifugal Maglev Blood Pump Through Design Variations. Front. Physiol. 2021;12. doi: 10.3389/fphys.2021.699891

[30] Wu P., Huo J., Dai W., et al. On the Optimization of a Centrifugal Maglev Blood Pump Through Design Variations // Front. Physiol. 2021. Vol. 12. doi: 10.3389/fphys.2021.699891

[31] Isaeva MS, Petrov AI, Banin EP. Razrabotka tsentrobezhnogo nasosa dlya sistem eks-trakorporalnoy membrannoy oksigenatsii s kolesom zakrytogo tipa. In: XXXV Mezhdunarodnaya innovatsionnaya konferentsiya molodykh uchenykh i studentov (MIKMUS — 2023): Sbornik trudov konferentsii, Moskva, 13–14 noyabrya 2023 goda. Moscow: IMash im AA Blagonravova RAN; 2023:309–315. EDN: WTDWLF

[32] Исаева М.С., Петров А.И., Банин Е.П. Разработка центробежного насоса для систем экстракорпоральной мембранной оксигенации с колесом закрытого типа. В кн.: XXXV Международная инновационная конференция молодых учёных и студентов (МИКМУС — 2023) : Сборник трудов конференции, Москва, 13–14 ноября 2023 года. Москва: ИМаш. им. А.А. Благонравова РАН, 2023. С. 309–315. EDN: WTDWLF

[33] Sukhanov DYa. Rabota lopastnykh nasosov na vyazkikh zhidkostyakh. Moscow: Mashgiz; 1952.

[34] Суханов Д.Я. Работа лопастных насосов на вязких жидкостях. М.: Машгиз., 1952.

[35] CentriMag™ Blood Pump Instructions For Use. Zurich: Thoratec Switzerland GmbH; 2019. Accessed: 25.06.2024. Available from: https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170038C.pdf.

[36] CentriMag™ Blood Pump Instructions For Use. Zurich: Thoratec Switzerland GmbH, 2019. Дата обращения: 25.06.2024. Режим доступа: https://www.accessdata.fda.gov/cdrh_docs/pdf17/P170038C.pdf.

[37] Conjunto para Circulação Extracorpórea MINI CEC. Instruções de Uso. Limeira: Cond Industrial Duas Barras; 2024. Accessed: 25.06.2024. Available from: https://cathcare.com.br/uploads/ifu/96-ifu-3b5810c44c2722c3709333eb2817a2fc7599c7d2.pdf

[38] Conjunto para Circulação Extracorpórea MINI CEC. Instruções de Uso. Limeira: Cond Industrial Duas Barras, 2024. Дата обращения: 25.06.2024. Режим доступа: https://cathcare.com.br/uploads/ifu/96-ifu-3b5810c44c2722c3709333eb2817a2fc7599c7d2.pdf

Funding

Правительство РФGovernment of the Russian Federation

RIGHTS & PERMISSIONS

Eco-Vector