THE ROLE OF ANTI-APOPTIC PROTEIN Bcl-2 IN DEVELOPMENT OF DRUG RESISTANCE IN CHILDREN WITH LOCALIZATION-RELATED EPILEPSY

Abstract

The main role of Bcl-2 protein and other proteins of its family is apoptosis regulation became known about 10 years ago, however we still receive new information about participation of this protein in various cellular processes, there is also a discussion about the role of Bcl-2 proteins in pathogenesis of various nervous system diseases and its possible use for diagnostic purposes. Studies of anti-apoptic protein Bcl-2 in children with localization-related epilepsy could help to find out the drug resistance mechanism and will help to take control over the attacks. Clinical-laboratory and instrumental examination of 31 children with localization-related epilepsy was carried out. It was revealed that the level of Bcl-2 anti-apoptic protein in children with drug resistance forms of localization-related epilepsy was statistically significantly higher, than in children of control group.

Keywords

localization-related epilepsy / drug-resistance form / protein Bcl-2 / immunoenzyme method

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RIGHTS & PERMISSIONS

Sokolova M.G., Lobzin S.V., Polyakova L.A., Rezvantsev M.V.