Predicting the course of uveitis against the background of juvenile idiophatic arthritis when using topical therapy regimens. The results of mathematical modeling

Vyacheslav G. Chasnyk; Anatolii V. Kononov; Vladimir V. Brzheskiy; Ekaterina V. Gaidar; Olga V. Kalashnikova; Margarita F. Dubko; Mikhail M. Kostik; Vera V. Masalova; Ludmila S. Snegireva; Tatiana N. Nikitina; Nadezhda E. Kononova

doi:10.17816/OV628282

Ophthalmology Reports ›› 2024, Vol. 17 ›› Issue (2) : 21 -29. DOI: 10.17816/OV628282

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Predicting the course of uveitis against the background of juvenile idiophatic arthritis when using topical therapy regimens. The results of mathematical modeling

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Saint Petersburg State Pediatric Medical University

North-West State Medical University named after I.I. Mechnikov

Saint Petersburg State Pediatric Medical University

MD, Dr. Sci. (Medicine), Professor

MD, Cand. Sci. (Medicine)

MD, Cand. Sci. (Medicine), Assistant Professor

MD, Dr. Sci. (Medicine), Professor

MD, Cand. Sci. (Medicine)

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Abstract

BACKGROUND: Juvenile idiopathic arthritis is the most common rheumatic disease in children, and uveitis is its most destructive extra-articular manifestation. Despite the existence of Federal clinical guidelines for the management of these patients, their treatment is largely based on the experience of doctors and varies greatly even within the same country.

AIM: The aim of the study is to find factors for predicting the course of uveitis and optimizing therapy.

MATERIALS AND METHODS: The case histories of 150 children aged 1.5 to 17 years with active uveitis in the structure of juvenile arthritis were analyzed using multifactorial modeling (construction of classification trees).

RESULTS: The fact of a significant influence of the time elapsed from the onset of rheumatic disease and uveitis until the start of therapy by genetically engineered medications (tumor necrosis factor alpha inhibitors) in treatment programs has been established.

CONCLUSIONS: Thus, the inclusion of this factor into the group of controlling ones makes it possible to achieve inactive uveitis status after 1, 3, and 6 months in a higher percentage of cases. However, the obtained data still require additional clinical confirmation.

Keywords

non-infectious uveitis / juvenile idiopathic arthritis / genetic engineering biological therapy / construction of classification trees

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Vyacheslav G. Chasnyk, Anatolii V. Kononov, Vladimir V. Brzheskiy, Ekaterina V. Gaidar, Olga V. Kalashnikova, Margarita F. Dubko, Mikhail M. Kostik, Vera V. Masalova, Ludmila S. Snegireva, Tatiana N. Nikitina, Nadezhda E. Kononova. Predicting the course of uveitis against the background of juvenile idiophatic arthritis when using topical therapy regimens. The results of mathematical modeling. Ophthalmology Reports, 2024, 17(2): 21-29 DOI:10.17816/OV628282

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References

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[1]	Drozdova EA. Medical and social aspects of uveitis in juvenile idiopathic arthritis. In: Materials of the interregional scientific and practical conference “Topical issues of ophthalmology”. Orenburg; 2013. P. 113–119. (In Russ.)

[2]	Дроздова Е.А. Медико-социальные аспекты увеита при ювенильном идиопатическом артрите. В кн.: Материалы межрегиональной научно-практической конференции «Актуальные вопросы офтальмологии». Оренбург, 2013. С. 113–119.

[3]	Galstyan LA, Zholobova ES, Chebysheva SN, et al. Uveitis associated with juvenile eidiopathic arthritis. Russian Bulletin of Perinatology and Pediatrics. 2019;64(2):30–37. EDN: SHIHNR doi: 10.21508/1027-4065-2019-64-2-30-37

[4]	Галстян Л.А., Жолобова Е.С., Чебышева С.Н., и др. Увеит, ассоциированный с ювенильным идиопатическим артритом // Российский вестник перинатологии и педиатрии. 2019. Т. 64, № 2. С. 30–37. EDN: SHIHNR doi: 10.21508/1027-4065-2019-64-2-30-37

[5]	Salugina SO, Katargina LA, Starikova AV. Rheumatological diseases and eyes lesions in children. Scientific and Practical Rheumatology. 2004;42(1):78–81. EDN: QCWZFJ

[6]	Салугина С.О., Катаргина Л.А., Старикова А.В. Ревматические заболевания и поражение глаз у детей // Научно-практическая ревматология. 2004. Т. 42, № 1. С. 78–81. EDN: QCWZFJ

[7]	Drozdova EA. The classification and epidemiology of uveitis. RMJ. Clinical Ophthalmology. 2016;16(3):155–159. EDN: ZNOGAL doi: 10.21689/2311-7729-2016-16-3-155-159

[8]	Дроздова Е.А. Вопросы классификации и эпидемиологии увеитов // РМЖ. Клиническая офтальмология. 2016. Т. 16, № 3. С. 155–159. EDN: ZNOGAL doi: 10.21689/2311-7729-2016-16-3-155-159

[9]	Katargina LA, Brzheskij VV, Guseva MR, et al. The federal clinical guidelines on “The diagnostics and treatment of uveitis associated with juvenile idiopathic arthritis”. Russian Pediatric Ophthalmology. 2016;11(2): 102–111. EDN: VXEJMP doi: 10.18821/1993-1859-2016-11-2-102-111

[10]

Катаргина Л.А., Бржеский В.В., Гусева М.Р., и др. Федеральные клинические рекомендации «Диагностика и лечение увеитов, ассоциированных с ювенильным идиопатическим артритом» // Российская педиатрическая офтальмология. 2016. Т. 11, № 2. С. 102–111. EDN: VXEJMP doi: 10.18821/1993-1859-2016-11-2-102-111

[11]	Zierhut M, Heiligenhaus A, deBoer J, et al. Controversies in juvenile idiopathic. Arthritis-associated uveitis. Ocul Immunol Inﬂamm. 2013;21(3):167–179. doi: 10.3109/09273948.2013.800561

[12]	Zierhut M., Heiligenhaus A., deBoer J., et al. Controversies in juvenile idiopathic. Arthritis-associated uveitis. Ocul Immunol Inﬂamm. 2013. Vol. 21, N. 3. P. 167–179. doi: 10.3109/09273948.2013.800561

[13]	habr.com [Internet]. What is a decision tree and where is it used? Mosсow; 2020 [cited: 23.11.2023]. Availible from: https://habr.com/ru/companies/productstar/articles/523044/

[14]	habr.com [интернет]. Что такое дерево решений и где его используют? Москва, 2020. Режим доступа: https://habr.com/ru/companies/productstar/articles/523044/ Дата обращения: 23.11.2023.