The role of genetic factors in the pathogenesis of primary open-angle glaucoma. Part 1. Connective tissue

Abstract

The article presents an analytical review of works devoted to molecular and genetic studies in primary open-angle glaucoma from the perspective of the concept of hereditary inferiority of the connective tissue of the eye (“scleral component”), and the entire body as a whole, as triggers in the development of the disease. The relationship between the main theories of the pathogenesis of glaucoma optical neuropathy and the determining role of molecular and genetic mechanisms of specific changes in the eye tissue is shown. The clinical features of primary open-angle glaucoma in patients with a family history are analyzed. Potentially new directions for preclinical diagnosis of glaucoma and pathogenetically oriented therapy are proposed.

Keywords

primary open-angle glaucoma / connective tissue / preclinical diagnostics / genetics / pathogenesis of glaucoma

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