The level of local cytokine production at different times after experimental ciliary body cryodestruction
Aleksey Nikolaevich Steblyuk , Natal'ya Vladislavovna Kolesnikova , Viktor Eduardovich Gyunter , Vadim Nikolaevich Bodnya , Anna Alekseevna Tserkovnaya
Ophthalmology Reports ›› 2015, Vol. 8 ›› Issue (1) : 22 -27.
The level of local cytokine production at different times after experimental ciliary body cryodestruction
We assessed the level of pro- (IL1β, FNOα, IL2) and anti-inflammatory (IL10) cytokines in the anterior chamber fluid of experimental animals on the 3rd, 7th and 30th day, after an experimental ciliary body destruсtion with porous titanium nickelid cryoapplicator. Consistent changes of the cytokine content at the local level are reflecting the reactivity of the experimental animals as an answer both to surgery in ciliary body area, and to its experimental cyclodestruction using the cryoapplicator from titanium nickelid. The predominance of pro-inflammatory cytokines’ potential was found during the early period (3-7 day), and the balance normalization of pro- and anti-inflammatory cytokines was found at late observation period (30 days) due to the increase of the anti-inflammatory IL-10 production; this effect was maintained at the end of the long-term study period (1.5 years).
ciliary body / cryosurgery / titanium nickelid / experimental animals
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Steblyuk A.N., Kolesnikova N.V., Gyunter V.E., Bodnya V.N., Tserkovnaya A.A.
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