Local cytokine status of experimental animalsat experimental intraocular implantationof titanium nickelide

Aleksey Nikolayevich Steblyuk; Natalya Vladislavovna Kolesnikova; Viktor Eduardovich Gyunter

doi:10.17816/OV201344-8

Ophthalmology Reports ›› 2013, Vol. 6 ›› Issue (4) : 4 -8. DOI: 10.17816/OV201344-8

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Local cytokine status of experimental animalsat experimental intraocular implantationof titanium nickelide

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Abstract

An assessment of the level of pro- (IL1β, FNOα, IL2) and anti-inflammatory (IL10) cytokines in the intraocular fluid of experimental animals at 3, 7 and 30 days after experimental intraocular implantation of porous titanium nickelide TN-10 was carried out. It was found that the implantation of porous titanium nickelide as drainage material does not impact the pro-inflammatory and anti-inflammatory cytokines’ local balance. It does cause an increase of IL1β, IL2 and IL10 production to the end of the first week of monitoring as well as a substantial limitation of anti-inflammatory FNOα synthesis. However at the end of the 30 day monitoring period, local IL1β and IL10 concentrations corresponded to those of control animals. At the same time, of some significance are obtained data upon a modulation of a caused by the surgical procedure disbalance in the system of local pro- and anti-inflammatory cytokines which is observed at the titanium nickelide TN-10 intraocular implantation.

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cytokines / intraocular implantation / animal eyes / titanium nickelide

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Aleksey Nikolayevich Steblyuk, Natalya Vladislavovna Kolesnikova, Viktor Eduardovich Gyunter. Local cytokine status of experimental animalsat experimental intraocular implantationof titanium nickelide. Ophthalmology Reports, 2013, 6(4): 4-8 DOI:10.17816/OV201344-8

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