Retinal and choroidal circulation in patients with lattice retinal degeneration: optical coherence tomography-angiography study

Abstract

BACKGROUND: There are insufficient data covering retinal and choroidal microcirculation in eyes with lattice retinal degeneration.

AIM: To investigate retinal and choroidal circulation in eyes with lattice retinal degeneration using optical coherence tomography-angiography (OCTA).

MATERIALS AND METHODS: The study included 10 patients with lattice retinal degeneration and 12 healthy individuals. All subjects underwent OCTA examination of the macula. Additionally, in four patients, OCTA within the area of lattice retinal degeneration was performed.

RESULTS: Retinal capillary non-perfusion, disorganization of retinal layers, a decrease of choriocapillaris perfusion, and choroidal thinning were found within the area of lattice degeneration in all cases. In the macula, the perfusion area in the choriocapillaris slab in the eyes with lattice degeneration and controls was 6.40 ± 0.21 and 6.19 ± 0.21 mm² (p < 0.05), respectively. The number of flow voids in the choriocapillaris in the eyes with lattice degeneration and controls eyes was 40.6 ± 23.0 and 65.1 ± 25.7 (p < 0.05), respectively. The total area of flow voids in the choriocapillaris slab in the eyes with lattice degeneration and in controls eyes was 0.49 ± 0.04 and 0.54 ± 0.04 mm² (p < 0.05), respectively.

CONCLUSIONS: The status the choroidal and choriocapillaris perfusion may play an important role in pathophysiology of the lattice retinal degeneration.

Keywords

lattice retinal degeneration / optical coherence tomography-angiography / choriocapillaris / choroid

References

[1] Straatsma BR, Zeegen PD, Foos RY, et al. XXX Edward Jackson Memorial Lecture. Lattice degeneration of the retina. Trans Am Acad Ophthalmol Otolaryngol. 1974;78(2):OP87–OP113.

[2] Straatsma B.R., Zeegen P.D., Foos R.Y., et al. XXX Edward Jackson Memorial Lecture. Lattice degeneration of the retina // Trans Am Acad Ophthalmol Otolaryngol. 1974. Vol. 78, No. 2. P. OP87-OP113.

[3] Byer NE. Lattice degeneration of the retina. Surv Ophthalmol. 1979;23(4):213–248. DOI: 10.1016/0039-6257(79)90048-1

[4] Byer N.E. Lattice degeneration of the retina // Surv Ophthalmol. 1979. Vol. 23, No. 4. P. 213–248. DOI: 10.1016/0039-6257(79)90048-1

[5] Choudhry N, Golding J, Manry MW, Rao RC. Ultra-widefield steering-based spectral-domain optical coherence tomography imaging of the retinal periphery. Ophthalmology. 2016;123(6):1368–1374. DOI: 10.1016/j.ophtha.2016.01.045

[6] Choudhry N., Golding J., Manry M.W., Rao R.C. Ultra-widefield steering-based spectral-domain optical coherence tomography imaging of the retinal periphery // Ophthalmology. 2016. Vol. 123, No. 6. P. 1368–1374. DOI: 10.1016/j.ophtha.2016.01.045

[7] Shaimova VA, Pozdeyeva OG, Shaimov TB, et al. Optical coherent tomography in diagnoses of peripheral retinal degenarations. Ophtalmologiia. 2013;10(4):32–40. (In Russ.) DOI: 10.18008/1816-5095-2013-4-32-40

[8] Поздеева О.Г., Шаимов Т.Б., Галин А.Ю., и др. Оптическая когерентная томография в диагностике периферических витреоретинальных дистрофий // Офтальмология. 2013. Т. 10, № 4. С. 32–40. DOI: 10.18008/1816-5095-2013-4-32-40

[9] Manjunath V, Taha M, Fujimoto JG, Duker JS. Posterior lattice degeneration characterized by spectral domain optical coherence tomography. Retina. 2011;31(3):492–496. DOI: 10.1097/IAE.0b013e3181ed8dc9

[10] Manjunath V., Taha M., Fujimoto J.G., Duker J.S. Posterior lattice degeneration characterized by spectral domain optical coherence tomography // Retina. 2011. Vol. 31, No. 3. P. 492–496. DOI: 10.1097/IAE.0b013e3181ed8dc9

[11] Tolentino FI, Lapus JV, Novalis G, et al. Fluorescein angiography of degenerative lesions of the peripheral fundus and rhegmatogenous retinal detachment. Int Ophthalmol Clin. 1976;16(1):13–29. DOI: 10.1097/00004397-197601610-00005

[12] Tolentino F.I., Lapus J.V., Novalis G., et al. Fluorescein angiography of degenerative lesions of the peripheral fundus and rhegmatogenous retinal detachment // Int Ophthalmol Clin. 1976. Vol. 16, No. 1. P. 13–29. DOI: 10.1097/00004397-197601610-00005

[13] Phansalkar N, More S, Sabale A, Joshi M. Adaptive local thresholding for detection of nuclei in diversely stained cytology images. Proc International Conf Commun Signal Process. 2011;218–220. DOI: 10.1109/ICCSP.2011.5739305

[14] Phansalkar N., More S., Sabale A., Joshi M. Adaptive local thresholding for detection of nuclei in diversely stained cytology images // Proc International Conf Commun Signal Process. 2011. P. 218–220. DOI: 10.1109/ICCSP.2011.5739305

[15] Torczynski E, Tso MO. The architecture of the choriocapillaris at the posterior pole. Am J Ophthalmol. 1976;81(4):428–440. DOI: 10.1016/0002-9394(76)90298-1

[16] Torczynski E., Tso M.O. The architecture of the choriocapillaris at the posterior pole // Am J Ophthalmol. 1976. Vol. 81, No. 4. P. 428–440. DOI: 10.1016/0002-9394(76)90298-1

[17] Burnasheva MA, Kulikov AN, Maltsev DS. Artifact-free evaluation of choriocapillaris perfusion in central serous chorioretinopathy. Vision (Basel). 2020;5(1):3. DOI: 10.3390/vision5010003

[18] Burnasheva M.A., Kulikov A.N., Maltsev D.S. Artifact-free evaluation of choriocapillaris perfusion in central serous chorioretinopathy // Vision (Basel). 2020. Vol. 5, No. 1. ID3. DOI: 10.3390/vision5010003

[19] Imanaga N, Terao N, Nakamine S, et al. Scleral thickness in central serous chorioretinopathy. Ophthalmol Retina. 2021;5(3):285–291. DOI: 10.1016/j.oret.2020.07.011

[20] Imanaga N., Terao N., Nakamine S., et al. Scleral thickness in central serous chorioretinopathy // Ophthalmol Retina. 2021. Vol. 5, No. 3. P. 285–291. DOI: 10.1016/j.oret.2020.07.011

[21] Maltsev DS, Kulikov AN, Burnasheva MA, et al. Axial length as a basic anatomical predictor for morphological and clinical characteristics in acute central serous chorioretinopathy. Eye (Lond). 2020;34(11):2063–2067. DOI: 10.1038/s41433-020-0774-7

[22] Maltsev D.S., Kulikov A.N., Burnasheva M.A., et al. Axial length as a basic anatomical predictor for morphological and clinical characteristics in acute central serous chorioretinopathy // Eye (Lond). 2020. Vol. 34, No. 11. P. 2063–2067. DOI: 10.1038/s41433-020-0774-7

RIGHTS & PERMISSIONS

Burnasheva M.A., Maltsev D.S., Kulikov A.N.