Dexmedetomidine vs clonidine. The best medication of prevention of hemodynamic response during awakening after craniotomy

Abstract

The paper is devoted to comparison of two drugs from the group of alpha-adrenoagonist: clonidine and dexmedetomidine, in the context of their impact on the quality of awakening in patients with neurosurgical profile. In the study of two groups of patients, the authors did not reveal a clear advantage or disadvantage of each drug, both of them were appropriate for the successful solution of the tasks.

Keywords

clonidine / dexmedetomidine / postoperative awakening

References

[1] Arefiev A.M., Kulikov A.C., Lubnin A.Yu. Dexmedetomidine in neuroanesthesiology. Anesteziologiya I Reanimatologiya. 2017; 62; 213–9; DOI: 10.18821/0201-7563-2017-62-3-213-219. (In Russian)

[2] Арефьев А.М., Куликов А.С., Лубнин А.Ю. Дексмедетомидин в нейроанестезиологии. Анестезиология и Реаниматология. 2017; 62; 213–9; DOI: 10.18821/0201-7563-2017-62-3-213-219

[3] Mizobe T., Maze M. Alpha 2-adrenoceptor agonists and anesthesia. Int Anesthesiol Clin. 1995; 33: 81–102.

[4] Kulka P.J., Tryba M., Zenz M. Dose–response effects of intravenous clonidine on stress response during induction of anesthesia in coronary artery bypass graft patients. Anesth. Analg.1995; 80 (2): 263–8.

[5] Tripathi D.C., Shah K.S, Dubey S.R, Doshi S.M., Raval P.V. Hemodynamic stress response during laparoscopic cholecystectomy: effect of two different doses of intravenous clonidine premedication. J. Anaesthesiol. Clin. Pharmacol. 2011; 27 (4): 475–80.

[6] Lawrence C.J., De Lange S. Effects of a single pre-operative dexmedetomidine dose of isoflurane requirements and peri-operative haemodynamic stability. Anaesthesia. 1997; 52 (8): 736–44.

[7] Keniya V.M, Ladi S., Naphade R. Dexmedetomidine attenuates sympathoadrenal response to tracheal intubation and reduces perioperative anaesthetic requirement. Indian J. Anaesth. 2011; 55: 352–7.

[8] Kim H., Choi S.H., Min K.T., Byon H.J. Randomized trial to compare the effect of a single dose of dexmedetomidine and continious infusion of remifentanil on airway reflex and hemodynamic response during emergence in pacients undergoing cerebral aneurysm clipping. European journal of Anaesthesiology. 2012; 29: 112–3.

[9] Turan G., Ozqultekin A., Turan C., Dincer E., Yuksel G. Advantageous effects of dexmedetomidine on haemodynamic ana recovery responses during extubation for intracranial surgery. Eur. J. Anaesthesiol. 2008; 25: 816–20. DOI:10.1017/S0265021508004201.

[10] Tanskanen P.E., Kytta J.V., Randell T.T., Aantaa R.E. Dexmedetomidine as an anaesthetic adjuvant in patients undergoing intracranial tumour surgery: a double-blind, randomised and placebo-controlled study. Br. J. Anaesth. 2006; 5: 658–65.

[11] Shmigel’skiy A.V., Polupon A.A., Kulikov A.S., Arefiev A.M. Intraoperative development of critical bradyarrhythmia on the background of dexmedetomidine. Case report. Regionarnaya anesteziya I lechenie ostroy boli. 2015; 9 (4): 22–6. (In Russian)

[12] Шмигельский А.В., Полупан А.А., Куликов А.С., Арефьев А.М. Интраоперационное развитие критической брадиаритмии на фоне применения дексмедетомидина. Клиническое наблюдение. Регионарная анестезия и лечение острой боли. 2015; 9 (4): 22–6.

[13] Guler G., Akın A., Tosun Z., Eskitas-c¸ıoglu E., Mızrak A., Boyacı A. The effects of Dexmedetomidine on the cardiovascular responses to tracheal extubation and quality of tracheal extubation in elderly patients undergoing cataract surgery. J. Turk. Anaesthesiol. Intensive Care Soc. 2005; 33: 18–23.

[14] Bharti D., Saran J., Kumar C., Nanda H.S. Comparison of Clonidine and Dexmedetomidine on Cardiovascular Stability in Laparoscopic Cholecystectomy. International Journal of Scientific Study. 2016; 4 (1). DOI: 10.17354/ijss/2016/185

[15] Bharti D., Saran J., Kumar C., Nanda H.S. Comparison of Clonidine and Dexmedetomidine on Cardiovascular Stability in Laparosco Cholecystectomy. International Journal of Scientific Study. 2016; 4 (1). DOI: 10.17354/ijss/2016/185

RIGHTS & PERMISSIONS

Eco-Vector