Effect of neuroaxial blockade on endocrine-metabolic and inflammatory response in abdominal surgery

P. A. Luboshevsky; A. M. Ovechkin; A. V. Zabusov

doi:10.17816/RA36054

Regional Anesthesia and Acute Pain Management ›› 2010, Vol. 4 ›› Issue (1) : 13 -17. DOI: 10.17816/RA36054

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Effect of neuroaxial blockade on endocrine-metabolic and inflammatory response in abdominal surgery

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Abstract

The aim of the study was to assess effect of different kind of neuroaxial blockade on endocrine-metabolic response as well as plasma concentration of pro- and anti-inflammatory cytokines in highly traumatic abdominal surgery. 60 patients who underwent elective abdominal surgery were included. The patients were classified into groups according to the type of surgery (upper or lower abdominal surgery) and way of anesthesia/analgesia (general anesthesia or general anesthesia combined with spinal/epidural one). Quality of postoperative analgesia, plasma concentration of glucose, cortisol and interleukins were measured. The results of our work indicate that using of neuroaxial anesthesia technique, namely epidural anesthesia/analgesia, allows of effective containing of surgical stress-response to promote reduction of postoperative complications.

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endocrine-metabolic response / cortisol / interleukin / stress-response

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P. A. Luboshevsky, A. M. Ovechkin, A. V. Zabusov. Effect of neuroaxial blockade on endocrine-metabolic and inflammatory response in abdominal surgery. Regional Anesthesia and Acute Pain Management, 2010, 4(1): 13-17 DOI:10.17816/RA36054

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