Potential of two-channel rheoophthalmography in the assessment of ocular blood flow in children and adolescents with myopia

Abstract

Aim. This study aimed to investigate the diagnostic potential of two-channel rheoophthalmography (ROG) in the assessment of ocular blood flow disorders in children and adolescents with myopia.

Material and methods. The method developed allowed one of the ROG channels to probe deep into the posterior pole of the eye and was designed to assess blood supply in the eye pole. Furthermore, the other channel was used to analyze blood flow in the temporal arteries — in the area of the ophthalmic and internal carotid arteries. Both signals were recorded simultaneously, which allows measuring of the blood flow distribution between these vascular regions. To assess the diagnostic potential of the method, two-channel rheoophthalmography signals were recorded and analyzed. The signals were obtained from 24 eyes (13 patients): 13 eyes (7 patients; median age, 14.1 years) with low myopia (−0.5 to −3.0 D) and 11 eyes (6 patients; median age, 23.7 years) with emmetropia (control group).

Results. In myopia patients, a relative increase of 4.1% in the ocular channel rheographic index (RI) was detected, whereas in the temporal channel, the RI increased simultaneously by 4.97%. The basic impedance (BI) indicator, obtained using the same method, increased by 22.4% in the ocular channel and by 29.5% in the temporal channel.

Conclusion. The simultaneous increase in BI in the temporal region and posterior eye pole area and proportional increase in pulse blood filling (RI) indicate that a change in blood supply in the posterior eye pole could be observed even in low myopia patients.

Keywords

electrical impedance / rheoophthalmography / eye / ocular blood flow

References

[1] Schmetterer L, Kiel J. Ocular Blood Flow. Springer; 2012.

[2] Schmetterer L., Kiel J. Ocular blood flow. Springer, 2012.

[3] Fan N, Wang P, Tang L, Liu X. Ocular blod flow and normal tension glaucoma. Biomed Res Int. 2015;2015:308505. Doi: 10.1155/2015/308505.

[4] Fan N., Wang P., Tang L., Liu X. Ocular blood flow and normal tension glaucoma // Biomed Res Int. 2015. V. 2015. P. 308505. Doi: 10.1155/2015/308505.

[5] Kiseleva TN, Adzhemian NA. Ocular blood flow assessment in vascular pathology of the eye. Regional blood circulation and microcirculation. 2015;14(4):4-10. (In Russ.). Doi: 10.24884/1682-6655-2015-14-4-4-10.

[6] Киселева Т.Н., Аджемян Н.А. Методы оценки глазного кровотока при сосудистой патологии глаза // Регионарное кровообращение и микроциркуляция. 2015. T. 14. № 4. C. 4-10. Doi: 10.24884/1682-6655-2015-14-4-4-10.

[7] Golzan SM, Avolio A, Graham SL. Hemodynamic interactions in the eye: a review. Ophthalmologica. 2012;228(4):214-221. Doi: 10.1159/000342157.

[8] Golzan S.M., Avolio A., Graham S.L. Hemodynamic interactions in the eye: a review // Ophthalmologica. 2012. V. 228. N 4. P. 214-221. Doi: 10.1159/000342157.

[9] Kunin VD, Svirina TA. Ocular blood flow depending on the age and arterial hypertension in healthy subjects. Glaucoma. 2002;(1):10-13. (In Russ.)

[10] Кунин В.Д., Свирина Т.А. Гемодинамика глаза у здоровых лиц в зависимости от возраста и уровня артериального давления // Глаукома. 2002. № 1. C. 10-13.

[11] Cybulski G. Ambulatory Impedance Cardiography. The systems and their applications. Springer-Verlag; 2011.

[12] Cybulski G. Ambulatory impedance cardiography. The systems and their applications. Springer-Verlag, 2011.

[13] Vasilyeva RM. Rheocardiography, an advanced noninvasive circulatory system test in children and adults: progress and prospects. Hum Physiol. 2017;43(2):229-239. Doi: 10.1134/S0362119717020165.

[14] Vasilyeva R.M. Rheocardiography, an advanced noninvasive circulatory system test in children and adults: progress and prospects // Hum Physiol. 2017. V. 43. N 2. P. 229-239. Doi: 10.1134/S0362119717020165.

[15] Bodo M. Studies in rheoencephalography. J Electr Bioimpedance. 2010;1(1):18-40. Doi: 10.5617/jeb.109.

[16] Bodo M. Studies in rheoencephalography // J Electr Bioimpedance. 2010. V. 1. N 1. P. 18-40. Doi: 10.5617/jeb.109.

[17] Avetisov ES, Katsnel’son LA, Savitskaya NF. Rheocyclographic examinations in myopia. Vestnik oftal’mologii. 1967;83(3):3-7. (In Russ.)

[18] Аветисов Э.С., Кацнельсон Л.А., Савицкая Н.Ф. Реоциклографические исследования при миопии // Вестник офтальмологии. 1967. T. 83. № 3. C. 3-7.

[19] Lazarenko VI, Kornilovsky IM, Il’enkov SS, et al. Our method of functional rheography of eye. Vestnik oftal’mologii. 1999;115(4):33-36. (In Russ.)

[20] Лазаренко В.И., Корниловский И.М., Ильенков С.С. и др. Наш метод функциональной реографии глаза // Вестник офтальмологии. 1999. T. 115. № 4. C. 33-36.

[21] Lazarenko VI, Komarovskikh EN. Results of the examination of hemodynamics of the eye and brain in patients with primary open-angle glaucoma. Vestnik oftal’mologii. 2004;120(1):32-36. (In Russ.)

[22] Лазаренко В.И., Комаровских Е.Н. Результаты исследования гемодинамики глаза и мозга у пациентов с первичной открытоугольной глаукомой // Вестник офтальмологии. 2004. T. 120. № 1. C. 32-36.

[23] Lazarenko VI. Functional Eye Rheography. Krasnoyarsk: Rastr; 2000. (In Russ.)

[24] Лазаренко В.И. Функциональная реография глаза. Красноярск : Растр, 2000.

[25] Luzhnov PV, Shamaev DM, Iomdina EN, et al. Transpalpebral tetrapolar reoophtalmography in the assessment of parameters of the eye blood circulatory system. Vestn Ross Akad Med Nauk. 2015;70(3):372-377. (In Russ.) Doi: 10.15690/vramn.v70i3.1336.

[26] Лужнов П.В., Шамаев Д.М., Иомдина Е.Н., и др. Транспальпебральная тетраполярная реоофтальмография в задачах оценки параметров системы кровообращения глаза // Вестник РАМН. 2015. T. 70. № 3. C. 372-377. Doi: 10.15690/vramn.v70i3.1336.

[27] Iomdina EN, Luzhnov PV, Shamaev DM, et al. An evaluation of transpalpebral rheoophthalmography as a new method of studying the blood supply to the eye in myopia. Russian ophthalmological journal. 2014;7(4):20-24. (In Russ.)

[28] Иомдина Е.Н., Лужнов П.В., Шамаев Д.М., и др. Оценка транспальпебральной реоофтальмографии как нового метода исследования кровоснабжения глаза при миопии // Российский офтальмологический журнал. 2014. T. 7. № 4. C. 20-24.

[29] Luzhnov PV, Shamaev DM, Iomdina EN, et al. Using quantitative parameters of ocular blood filling with transpalpebral rheoophthalmography. In: Eskola H, Väisänen O, Viik J, Hyttinen J, editors. IFMBE Proceedings. Singapore: Springer; 2017. p. 37-40. Doi: 10.1007/978-981-10-5122-7_10.

[30] Luzhnov P.V., Shamaev D.M., Iomdina E.N. et al. Using quantitative parameters of ocular blood filling with transpalpebral rheoophthalmography // Eskola H., Väisänen O., Viik J., Hyttinen J., editors. IFMBE Proceedings. Vol. 65. Singapore: Springer, 2017. p. 37-40. Doi: 10.1007/978-981-10-5122-7_10.

[31] Shamaev DM, Luzhnov PV, Iomdina EN. Modeling of ocular and eyelid pulse blood filling in diagnosing using transpalpebral rheoophthalmography. In: Eskola H, Väisänen O, Viik J, Hyttinen J, editors. IFMBE Proceedings. Singapore: Springer; 2017. p. 1000-1003. Doi: 10.1007/978-981-10-5122-7_250.

[32] Shamaev D.M., Luzhnov P.V., Iomdina E.N. Modeling of ocular and eyelid pulse blood filling in diagnosing using transpalpebral rheoophthalmography // Eskola H., Väisänen O., Viik J., Hyttinen J., editors. IFMBE Proceedings. Vol. 65. Singapore: Springer, 2017. p. 1000-1003. Doi: 10.1007/978-981-10-5122-7_250.

[33] Standring S. Gray’s Anatomy: The Anatomical Basis of Clinical Practice. 39th ed. Elsevier; 2005.

[34] Standring S. Gray’s anatomy: the anatomical basis of clinical practice. 39th ed. Elsevier, 2005.

[35] Luzhnov PV, Kiseleva AA, Iomdina EN, Vasilenkova LV. Features of using the rheoophthalmography methods in the analysis of ocular blood flow in posterior part of the eye. In: Xuesong Y, Fred A, Gamboa H, editors. Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020). Valletta, Malta; 2020. P. 263-267. Doi: 10.5220/0009165902630267.

[36] Luzhnov P.V., Kiseleva A.A., Iomdina E.N., Vasilenkova L.V. Features of using the rheoophthalmography methods in the analysis of ocular blood flow in posterior part of the eye // Xuesong Y., Fred A., Gamboa H., editors. Proceedings of the 13th International Joint Conference on Biomedical Engineering Systems and Technologies (BIOSTEC 2020). Valletta, Malta, 2020. p. 263-267. Doi: 10.5220/0009165902630267.

[37] Patent RUS 189501/ 24.05.2019. Iomdina EN, Luzhnov PV, Shamaev DM, et al. Device for multichannel electrical impedance evaluation of blood circulation in ophthalmic artery and vessels of anterior part of the brain. (In Russ.)

[38] Патент РФ №189501/ 24.05.2019. Иомдина Е.Н., Лужнов П.В., Шамаев Д.М., Киселева А.А., Маркосян Г.А. Устройство для многоканальной электроимпедансной оценки кровотока в глазничной артерии и сосудах передней части головного мозга.

[39] Sokolova IV, Yarullin KK, Maksimenko IM, Ronkin MA. Analysis of the structure of rheoencephalogram as a pulse filling of blood. Journal of Nevropathol. 1977;77:1314-1321. (In Russ.)

[40] Соколова И.В., Яруллин Х.Х., Максименко И.М., Ронкин М.А. Анализ структуры реоэнцефалограммы как биосигнала пульсового кровенаполнения // Журнал невропатологии и психиатрии им. С.С. Корсакова. 1977. T. 77. C. 1314-1321.

[41] Kiseleva AA, Luzhnov PV, Shamaev DM. Verification of mathematical model for bioimpedance diagnostics of the blood flow in cerebral vessels. In: Hu Z, Petoukhov SV, He M, editors. Advances in Intelligent Systems and Computing. Switzerland: Springer Nature; 2020. p. 251-259. Doi: 10.1007/978-3-030-12082-5_23.

[42] Kiseleva A.A., Luzhnov P.V., Shamaev D.M. Verification of mathematical model for bioimpedance diagnostics of the blood flow in cerebral vessels // Hu Z., Petoukhov S.V., He M., editors. Advances in Intelligent Systems and Computing. Switzerland: Springer Nature, 2020. p. 251-259. Doi: 10.1007/978-3-030-12082-5_23.

RIGHTS & PERMISSIONS

Eco-Vector