Clinical assessment of the periodontal tissues during complex treatment of patients with chronic generalized periodontitis using herbal rinse

Abstract

BACKGROUND: Preserving the effect of periodontal disease treatment and choosing an individual oral care program are urgent issues in dentistry.

AIM: To examine the clinical dynamics and index indicators of the state of the oral cavity in patients with mild but chronic generalized periodontitis (CGP) before and after complex treatment using a mouthwash (“Art-Dental Expert”; LLC “KorolevPharm”).

MATERIALS AND METHODS: The study was conducted in the main (using “Art-Dental Expert” mouthwash) and control (using 0.05% solution of chlorhexidine bigluconate) groups of patients with mild CGP. The state of periodontal tissues was assessed using a simplified hygiene index (OHI-S, Green–Vermillion), probing bleeding index (BOP), papillary–marginal–alveolar index (PMA), and the index of the need for periodontal disease treatment (CPITN).

RESULTS: The main group showed positive dynamics of changes in the indices characterizing the state of the periodontium, with a significant difference in indicators when compared with the control group.

CONCLUSION: The use of “Art-Dental Expert” mouthwash for the treatment of patients with mild CGP has a fast and stable prolonged clinical effect with normalization of qualitative and quantitative indicators of the state of periodontal tissues. The “Art-Dental Expert” mouthwash can be recommended for long-term use.

Keywords

generalized periodontitis / complex treatment of periodontal diseases / herbal preparations / mouth rinses / pomegranate peel

References

[1] Grudyanov AI, Ovchinnikova VV. Prevention of inflammatory periodontal diseases. Moscow: MIA; 2007. (In Russ).

[2] Грудянов А.И., Овчинникова В.В. Профилактика воспалительных заболеваний пародонта. Москва : МИА, 2007.

[3] Mhoyan GR, Razumova SN, Volkov AG, et al. The effect of removing dental plaque with low-frequency ultrasound and ozonized contact medium on the microbiota of the gingival sulcus with diagnosis chronic catarrhal gingivitis of young age patients. Medical Alphabet. 2021;(24):98–101. doi: 10.33667/2078- 5631-2021-24-98-101

[4] Мхоян Г.Р., Разумова С.Н., Волков А.Г., и др. Влияние удаления зубных отложений с помощью низкочастотного ультразвука и озонированной контактной среды на микробиоту десневой борозды при хроническом катаральном гингивите у лиц молодого возраста // Медицинский алфавит. 2021. № 24. С. 98–101. doi: 10.33667/2078- 5631-2021-24-98-101

[5] Mhoyan GR, Razumova SN, Volkov AG, et al. Study of the effect of removing dental plaque using low-frequency ultrasound and ozonized contact medium on the clinical course of chronic generalized catarrhal gingivitis of young people. Medical Alphabet. 2021;(12):16–20. doi: 10.33667/2078-5631-2021-12-16-20

[6] Мхоян Г.Р., Разумова С.Н., Волков А.Г., и др. Изучение влияния удаления зубных отложений с помощью низкочастотного ультразвука и озонированной контактной среды на клиническое течение хронического генерализованного катарального гингивита у лиц молодого возраста // Медицинский алфавит. 2021. № 12. С. 16–20. doi: 10.33667/2078-5631-2021-12-16-20

[7] Thabet MAK, Razumova SN, Brago AS, et al. Different methods of professional oral hygiene. Literature review. Medical Alphabet. 2022;(7):15–19. doi: 10.33667/2078-5631-2022-7-15-19

[8] Табет М.А.К., Разумова С.Н., Браго А.С., и др. Проведение профессиональной гигиены у пациентов с использованием различных методик. Состояние вопроса (обзор литературы) // Медицинский алфавит. 2022. № 7. С. 15–19. doi: 10.33667/2078-5631-2022-7-15-19

[9] Razumova SN, Brago AS, Kozlova YuS, Fomina AD, Glybina TA. Clinical study of the toothpaste for the treatment of dental hypersensitivity. Russian Journal of Dentistry. 2021;25(5):423–430. doi: 10.17816/1728-2802-2021-25-5-423-430

[10] Разумова С.Н., Браго А.С., Козлова Ю.С., Фомина А.Д., Глыбина Т.А. Клиническое исследование эффективности применения зубной пасты для лечения гиперчувствительности зубов // Российский стоматологический журнал. 2021. Т. 25, № 5. С. 423–430. doi: 10.17816/1728-2802-2021-25-5-423-430

[11] Razumova SN, Brago AS, Manvelyan AS. The effectiveness use of toothpaste with anti-carious effect. Medical Alphabet. 2021;(24):14–18. doi: 10.33667/2078-5631-2021-24-14-18

[12] Разумова С.Н., Браго А.С., Манвелян А.С., и др. Эффективность применения зубной пасты с противокариозным эффектом // Медицинский алфавит. 2021. № 24. С. 14–18. doi: 10.33667/2078-5631-2021-24-14-18

[13] Razumova SN, Kozlova YS, Brago AS, Razumov NM, Glybina TA. Study of the effect of using a hard toothbrush with a high abrasive toothpaste according to profilometry data. Medical Alphabet. 2021;(38):41–44. doi: 10.33667/2078-5631-2021-38-41-44

[14] Разумова С.Н., Козлова Ю.С., Браго А.С., Разумов Н.М., Глыбина Т.А. Изучение влияния применения жёсткой щётки с пастой высокой степени абразивности по данным профилометрии // Медицинский алфавит. 2021. № 38. С. 41–44. doi: 10.33667/2078-5631-2021-38-41-44

[15] Razumova SN, Kozlova YS, Brago AS, Barakat H, Manvelyan AS. Evaluation of the roughness of the enamel surface according to profilometry data (pilot study). Medical Alphabet. 2022;(34):14–18. doi: 10.33667/2078-5631-2022-34-14-18

[16] Разумова С.Н., Козлова Ю.С., Браго А.С., Баракат Х., Манвелян А.С. Оценка шероховатости поверхности эмали по данным профилометрии (пилотное исследование) // Медицинский алфавит. 2022. № 34. С. 14–18. doi: 10.33667/2078-5631-2022-34-14-18

[17] Centers for Disease Control and Prevention [Internet]. Antibiotic resistance threats in the United States. 2019 [cited 2020 March 15]. Available from: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf

[18] Centers for Disease Control and Prevention [Internet]. Antibiotic resistance threats in the United States. 2019 [дата обращения: 15.03.2020]. Доступ по ссылке: https://www.cdc.gov/drugresistance/pdf/threats-report/2019-ar-threats-report-508.pdf

[19] Qaralleh H. Thymol rich thymbra capitata essential oil inhibits quorum sensing, virulence and biofilm formation of Beta Lactamase producing Pseudomonas aeruginosa. Nat Prod Sci. 2019;25(2):172–180. doi: 10.20307/nps.2019.25.2.172

[20] Qaralleh H. Thymol rich Thymbra capitata essential oil inhibits quorum sensing, virulence and biofilm formation of Beta Lactamase producing Pseudomonas aeruginosa // Nat Prod Sci. 2019. Vol. 25, N 2. P. 172–180. doi: 10.20307/nps.2019.25.2.172

[21] Abdurakhmanova SA, Runova GS. Review of modern herbal preparations used in treatment of inflammatory periodontal diseases. Russian Stomatology. 2018;11(4):37–41. doi: 10.17116/rosstomat20181104137

[22] Абдурахманова С.А., Рунова Г.С. Обзор современных фитопрепаратов, применяемых в лечении воспалительных заболеваний пародонта // Российская стоматология. 2018. Т. 11, № 4. С. 37–41. doi: 10.17116/rosstomat20181104137

[23] Goncharova EI. The use of the herbal medicinal products for the prevention and treatment of periodontal diseases. Russian Journal of Dentistry. 2012;(3):48–52.

[24] Гончарова Е.И. Растительные средства в профилактике и лечении заболеваний пародонта // Российский стоматологический журнал. 2012. № 3. С. 48–52.

[25] Dudar MV, Vasilyeva LS, Molokov VD. Modern trends in medical therapy of chronic generalized parodontitis. Byulleten’ VSNTs SO RAMN. 2016;1(6):197–205. doi: 10.12737/23841

[26] Дударь М.В., Васильева Л.С., Молоков В.Д. Современные направления медикаментозной терапии хронического генерализованного пародонтита // Бюллетень ВСНЦ СО РАМН. 2016. Т. 1, № 6. С. 197–205. doi: 10.12737/23841

[27] Wu-Yuan CD, Green L, Birch WX. In vitro screening of Chinese medicinal toothpastes: their effects on growth and plaque formation of Mutans Streptococci. Caries Res. 1990;24(3):198–202. doi: 10.1159/000261265

[28] Wu-Yuan C.D., Green L., Birch W.X. In vitro screening of Chinese medicinal toothpastes: their effects on growth and plaque formation of Mutans Streptococci // Caries Res. 1990. Vol. 24, N 3. P. 198–202. doi: 10.1159/000261265

[29] Chandra Shekar BR, Nagarajappa R, Suma S, Thakur R. Herbal extracts in oral health care—A review of the current scenario and its future needs. Pharmacogn Rev. 2015;9(18):87–92. doi: 10.4103/0973-7847.162101

[30] Chandra Shekar B.R., Nagarajappa R., Suma S., Thakur R. Herbal extracts in oral health care—A review of the current scenario and its future needs // Pharmacogn Rev. 2015. Vol. 9, N 18. P. 87–92. doi: 10.4103/0973-7847.162101

[31] Inagaki Y, Kido JI, Nishikawa Y, et al. Gan-Lu-Yin (Kanroin), traditional Chinese herbal extracts, reduces osteoclast differentiation in vitro and prevents alveolar bone resorption in rat experimental periodontitis. J Clin Med. 2021;10(3):386. doi: 10.3390/jcm10030386

[32] Inagaki Y., Kido J.I., Nishikawa Y., et al. Gan-Lu-Yin (Kanroin), traditional Chinese herbal extracts, reduces osteoclast differentiation in vitro and prevents alveolar bone resorption in rat experimental periodontitis // J Clin Med. 2021. Vol. 10, N 3. 386. doi: 10.3390/jcm10030386

[33] Song HK, Noh EM, Kim JM, et al. Evodiae fructus extract inhibits interleukin-1β-induced MMP-1, MMP-3, and inflammatory cytokine expression by suppressing the activation of MAPK and STAT-3 in human gingival fibroblasts in vitro. Evid Based Complement Alternat Med. 2021;2021:5858393. doi: 10.1155/2021/5858393

[34] Song H.K., Noh E.M., Kim J.M., et al. Evodiae fructus extract inhibits interleukin-1β-induced MMP-1, MMP-3, and inflammatory cytokine expression by suppressing the activation of MAPK and STAT-3 in human gingival fibroblasts in vitro // Evid Based Complement Alternat Med. 2021. Vol. 2021. 5858393. doi: 10.1155/2021/5858393

[35] Southern EN, McCombs GB, Tolle SL, Marinak K. The comparative effects of 0.12٪ chlorhexidine and herbal oral rinse on dental plaque-induced gingivitis. J Dent Hyg. 2006;80(1):12.

[36] Southern E.N., McCombs G.B., Tolle S.L., Marinak K. The comparative effects of 0.12% chlorhexidine and herbal oral rinse on dental plaque-induced gingivitis // J Dent Hyg. 2006. Vol. 80, N 1. 12.

[37] Karygianni L, Al-Ahmad A, Argyropoulou A, et al. Natural antimicrobials and oral microorganisms: A systematic review on herbal interventions for the eradication of multispecies oral biofilms. Front Microbiol. 2016;6:1529. doi: 10.3389/fmicb.2015.01529

[38] Karygianni L., Al-Ahmad A., Argyropoulou A., et al. Natural antimicrobials and oral microorganisms: A systematic review on herbal interventions for the eradication of multispecies oral biofilms // Front Microbiol. 2016. Vol. 6. 1529. doi: 10.3389/fmicb.2015.01529

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