PAMPURA ENDOGENOUS ANTIMICROBIAL POLYPEPTIDES - FACTORS OF NONSPECIFIC PROTECTION OF THE ORGANISM

Abstract

Despite advances in the treatment of oral diseases, dental caries, its complicated forms and diseases of the mucous membranes of the oral cavity are often found in children. Proved a clear link between the state of the oral cavity and the General somatic status of the child, the state of his immunity. One of the neglected components of the innate immune system are antimicrobial peptides (AMP). AMP can be found virtually in all physiological liquids, as well as the epithelium of the skin and mucous membranes. Peptides are important in the oral cavity, where microbial flora is present in high concentration constantly; AMP are natural antibiotics, which provide the first line of defense against a wide range of pathogens. There are three main groups of amino acid composition and the three-dimensional structure: a-helical peptides without cysteine (cathelicidins) peptides with three disulfide bonds (a - and b-defensine), and peptides with a high number of amino acids (histatin). Recent studies show the importance of defensine and cathelicidin as antibacterial agents of the mouth, while histatine has a pronounced anti-fungal and prevents the formation of microbial film on the surface of the tooth.

Keywords

antimicrobial polypeptides / a- / b- defensines / cathelicidins / atopic dermatitis

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