CYTOKINE PROFILE OF BLOOD PLASMA AND GINGIVAL FLUID FROM THE RESIDENTS OF DAGESTAN IN CHRONIC PERIODONTITIS

Abstract

Presents the results of the survey of 131 patients of different nationalities, including 69 - residents of Dagestan, 62 - a metropolis of Moscow and the Moscow region (Slavs). In 58 was diagnosed with chronic periodontitis in the stage of exacerbation. With the help of PCR installed reliable difference frequency of detection periodontitis pathogenic species A.actinomycetemcomitans, T.forsythia, P.gingivalis, T.denticola, F.nucleatum the inhabitants of indigenous peoples of Dagestan and the Slavs of the megapolis of Moscow. In respect of the P. intermedia, P. micros, E. corrodens differences have not been identified. With the help of the EIA revealed a statistically significant difference of the level of proinflammatory cytokines IL-1β, IL-6 and TNF-α in the plasma of blood and gingival fluid of the pathology of periodontal the population of Dagestan and Slavs, but not the anti-inflammatory. Is that a sharp increase in the level of cytokines in the inhabitants of Dagestan may be due to the greater frequency of infection with pathogenic species or genetic polymorphism of genes coding for the synthesis of IL-1β, IL-6 and TNF-α.

Keywords

the people of Dagestan / Slavs / PCR / ELISA / periodontitis pathogenic species / cytokines

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