CHARACTERISTICS OF APOPTOSIS AND NO SYNTHASE IN THE MUCOUS MEMBRANE OF THE HUMAN THE MAXILLARY SINUS IN CASE OF AN INJURY AND CHRONIC INFLAMMATION

Abstract

This study has demonstrated that a mechanical injury and chronic rhinosinusitis are associated with a rise in the activity of an inducible isoenzyme of N0 synthase (iNOS) and an increase of the apoptotic index in the mucous cells of the maxillary sinus of man. In the case of a fracture of the upper jaw, the apoptotic nuclei are visualized throughout the entire cross section of the many-layer epithelium and the mucous membrane showing the tendency toward assembling into focal groups. However, under conditions of chronic inflammation, the apoptotic fibroblast-like and mast cells predominate in the deep-lying submucous layers. The results of the study are discussed in the context of the data about the cytotoxic and apoptogenic function of NO in the mucous membrane.

Keywords

apoptosis / NO-synthesizing systems in the mucous membrane of the human maxillary sinus / injury / chronic inflammation

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