Dynamics of indicators of the proteinase-inhibitory system of the body in destructive forms of chronic apical periodontitis during treatment

Abstract

BACKGROUND: Destructive forms of chronic apical periodontitis (CAP) remain one of the most difficult problems not only in dentistry and endodontics but also in medicine. In addition to the progressive local process in the alveolar process of the jaw, they are a source of autoinfection and auto-intoxication, causing or exacerbating pathologies in other organs.

AIM: This study aimed to analyze the dynamics of the activity of nonspecific proteinases and their inhibitors in patients with destructive forms of CAP when performing a standard endodontic treatment.

MATERIALS AND METHODS: Some indicators of the proteinase-inhibitory system of the oral fluid and blood plasma were studied in 28 somatically healthy patients aged 25–55 years with destructive forms of CAP in multi-root teeth. The canals were treated according to the protocol of the European Society of Endodontics. After instrumental and medical treatments of the root canal, it was dried and temporarily sealed with calcium hydroxide-based preparation. The tooth was closed with temporary fillers for 10–14 days.

RESULTS: The comparative analysis of the indicators of the proteinase-inhibitory system showed that destructive forms of CAP and rehabilitation of the pathological focus, to a greater or lesser extent, affect its condition.

CONCLUSIONS: Changes in the parameters of the proteinase-inhibitory system in the development of CAP during endodontic treatment were observed both locally (oral fluid) and systemically (blood plasma).

Keywords

chronic apical periodontitis / oral fluid / blood plasma / proteolysis / proteinases

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Demyanenko S.A., Morozova M.N., Kharchenko V.Z., Tofan Y.V., Aliyev L.L., Duryagina L.K., Degtyareva L.A., Dubrovina-Parus T.A.