Treatment of patients with radiation-induced xerostomia using saliva substitutes as an integral part of complex substitution therapy

Abstract

BACKGROUND: Dry mouth (xerostomia) can be a symptom of various diseases of human organs and systems and caused by prolonged intake of medications as well as chemoradiation treatment of malignant tumors of the maxillofacial area. Xerostomia treatment remains a challenging task.

AIM: This study aimed to improve the treatment methods of patients with xerostomia.

MATERIAL AND METHODS: Fifty patients with xerostomia were treated and distributed into two groups. Group 1 consisted of 23 patients treated with Hiposalix spray (France). Group 2 included 27 patients treated using the Xerostom (Spain) saliva substitute. All patients underwent sialometry, sialography, and study of the secretion viscosity before and after treatment.

RESULTS: At 1 month after treatment, 22 (96%) patients of group 1 noted an improvement. At the same time, an objective increase in the secretion level was detected in 2 (9%) patients. All patients of group 2 noted significant improvement in the condition of the oral cavity. However, sialometry showed that the level of saliva secretion remained the same.

CONCLUSIONS: Thus, the use of saliva substitutes produced by Hiposalix and Xerostom significantly reduced or prevented the subjective sensation of dry mouth without an objective increase in saliva secretion.

Keywords

radiation-induced xerostomia / dry mouth / salivary glands / saliva substitutes

References

[1] Afanasyev VV. Salivary glands. Diseases and injuries. Moscow: GEOTAR-Media; 2012. 296 p. (In Russ).

[2] Афанасьев В.В. Слюнные железы. Болезни и травмы. Москва: ГЭОТАР-Медиа, 2012. 296 с.

[3] Mortazvi H, Baharvand M, Movahhedian A, et al. Xerostomia due to systemic desease: a review of conditions and mechanisms. Ann Med Health Sci Res. 2014;4(4)503–510. doi: 10.4103/2141-9248.139284

[4] Mortazvi H., Baharvand M., Movahhedian A., et al. Xerostomia due to systemic desease: a review of conditions and mechanisms // Ann Med Health Sci Res. 2014. Vol. 4, N 4. P. 503–510. doi: 10.4103/2141-9248.139284

[5] Healthcare in Russia 2017: Statistical Collection of Rosstat. Moscow; 2017. 170 p. (In Russ).

[6] Здравоохранение в России 2017: статистический сборник Росстата. Москва, 2017. 170 с.

[7] Vorobyov YuI. Radiotherapy of maxillofacial malignant tumors and dental problems. Russian Journal of Dental. 2006;(5):24–29. (In Russ).

[8] Воробьев Ю.И. Лучевая терапия злокачественных опухолей челюстно-лицевой области и стоматологические проблемы // Российский стоматологический журнал. 2006. №. 5. С. 24–29.

[9] Obukhov YA, Zhukovskaya EV, Karelin AF. Radiation caries in patients receiving therapy for neoplasms: literature review and own clinical observations. Russian Journal of Pediatric Hematology and Oncology. 2018;5(4):40–50. (In Russ). doi: 10.17650/2311-1267-2018-5-4-40-50

[10] Обухов Ю.А., Жуковская Е.В., Карелин А.Ф. Лучевой кариес у пациентов, получающих терапию по поводу новообразований: обзор литературы и собственные клинические наблюдения // Российский журнал детской гематологии и онкологии. 2018. Т. 5, № 4. С. 40–50. doi: 10.17650/2311-1267-2018-5-4-40-50

[11] Zurnachyan AA. Radiation lesions of the oral mucosa after radiotherapy: approaches to prevention and treatment. Kazan Medical Journal. 2015;96(3):397–400. (In Russ). doi: 10.17750/KMJ2015-397

[12] Зурначян А.А. Лучевые поражения слизистой оболочки полости рта после радиотерапии: подходы к профилактике и лечению // Казанский медицинский журнал. 2015. Т. 96, № 3. С. 397–400. doi: 10.17750/KMJ2015-397

[13] Jaguar GC, Prado JD, Campanhã D, Alves FA. Clinical features and preventive therapies of radiation-induced xerostomia in head and neck cancer patient: a literature review. Appl Cancer Res. 2017;37:31. doi: 10.1186/s41241-017-0037-5

[14] Jaguar G.C., Prado J.D., Campanhã D., Alves F.A. Clinical features and preventive therapies of radiation-induced xerostomia in head and neck cancer patient: a literature review // Appl Cancer Res. 2017. Vol. 37. Р. 31. doi: 10.1186/s41241-017-0037-5

[15] Berk LB, Shivnani AT, Small WJ. Pathophisiology and mana- gement of radiation-induced xerostomia. J Support Oncol. 2005;3(3):191–200.

[16] Berk L.B., Shivnani A.T., Small W.J. Pathophisiology and management of radiation-induced xerostomia // J Support Oncol. 2005. Vol. 3, N 3. P. 191–200.

[17] Getman AD. Radiation-induced xerostomia: a modern view of the problem of radiation lesions of the salivary glands. The origins and prospects of Russian sialology. In the field of view - the Middle Urals: materials of the anniversary scientific and practical conference with international participation, dedicated to the 70th anniversary of the birth of the Honored Worker of the Higher School of the Russian Federation, Doctor of Medical Sciences, Professor Ron Galina Ivanovna, June 1, 2018. Yekaterinburg; 2018. 200 p.

[18] Гетьман А.Д. Радиационно-индуцированная ксеростомия: современный взгляд на проблему лучевых поражений слюнных желез // Истоки и перспективы отечественной сиалологии. В поле зрения ― Средний Урал: материалы юбилейной научной-практической конференции с международным участием, посвященной 70-летию со дня рождения заслуженного работника высшей школы Российской Федерации, доктора медицинских наук, профессора Ронь Галины Ивановны, 1 июня 2018 года. Екатеринбург, 2018. 200 с.

RIGHTS & PERMISSIONS

Eco-Vector