Effectiveness of nicotinamide adenine nucleotide hydride in the complex treatment of patients with peri implantitis

Abstract

Background: In treating peri-implantitis, dentists pay attention to drugs that do not contain chemically aggressive agents. They rather use those having natural mechanisms for normalization of the functional activity of cells and tissues in addition to local antiseptic and antibacterial agents.

The aim of the study was to determine the clinical effectiveness of nicotinamide adenine nucleotide hydride dental gel in the treatment of peri-implantitis.

Materials and methods: Depending on the therapeutic tactics patients (n = 40), we divided patients into two groups. In Group 1 (n = 20), we used a standard treatment of peri-implantitis including professional hygiene measures, antiseptic treatment and the use of antibacterial agents. In Group 2 (n = 20), the complex treatment included photodynamic effects of 1% photosensitizer gel instead of the antibacterial therapy.

Results: Due to the use of the photodynamic therapy in addition to standard treatment of group 2 patients, the concentration of a tartrate-resistant acid phosphatase in the peri-implantation exudate reached the level of healthy people in the gingival fluid. In addition, the concentrations of cathepsin K and interleukin-6 were as close as possible to the control level.

Conclusion: The use of NADH for peri-implantitis helps to eliminate inflammatory phenomena and stimulates the regeneration of the oral mucosa.

Keywords

chronic peri-implantitis / hypoxia dependent reactions / regeneration / dental gel

References

[1] Renvert S, Persson GR. Periodontitis as a potential risk factor for peri-implantitis. J Clin Periodontol. 2009;36(Suppl 10):9–14. doi: 10.1111/j.1600–051X.2009.01416.x.

[2] Renvert S., Persson G.R. Periodontitis as a potential risk factor for peri-implantitis. J Clin Periodontol. 2009;36(Suppl 10):9–14. doi: 10.1111/j.1600–051X.2009.01416.x.

[3] Lindhe J, Meyle J; Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008;35(8 Suppl): 282–5. doi: 10.1111/j.1600–051X.2008.01283.x.

[4] Lindhe J., Meyle J.; Group D of European Workshop on Periodontology. Peri-implant diseases: Consensus Report of the Sixth European Workshop on Periodontology. J Clin Periodontol. 2008;35(8 Suppl):282–5. doi: 10.1111/j.1600–051X.2008.01283.x.

[5] Solovyova AM. Peri-implantitis: steps to reach a consensus on diagnostics and treatment. Klinicheskaya stomatologiya. 2011;(1):50–2. (in Rus-sian)

[6] Соловьева А.М. Периимплантит: этапы достижения консенсуса в диагностике и лечении. Клиническая стоматология. 2011;(1):50–2.

[7] Amkhadova MA, Kopetsky IS, Prokopyev VV. Effectiveness ofphotodynamic therapy in treatment of chronic generalized periodontitis. Med-itsinskiy alfavit. 2016;1(2):31–5. (in Russian)

[8] Амхадова М.А., Копецкий И.С., Прокопьев В.В. Комплексное лечение пациентов с хроническим генерализованным пародонтитом с приме-нением фотодинамической терапии. Медицинский алфавит. 2016;1(2):31–5.

[9] Ovcharenko ES, Erichev VV, Aksenova TV, Melekhov SV. Immunological and microbiological evaluation of oral hygiene effectiveness in complex treatment of patients with inflammatory periodontal diseases. Meditsinskiy alfavit. 2017;3(24):38–41. (in Russian)

[10] Овчаренко Е.С., Еричев В.В., Аксенова Т.В., Мелехов С.В. Иммунологическая и микробиологическая оценка эффективности гигиены полости рта в комплексном лечении больных с воспалительными заболеваниями пародонта. Медицинский алфавит. 2017;3(24):38–41.

[11] Song ZC, Zhou W, Shu R, Ni J. Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF–1alpha pathway. Cell Prolif. 2012;45(3):239–48. doi: 10.1111/j.1365–2184.2012.00810.x.

[12] Song Z.C., Zhou W., Shu R., Ni J. Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF–1alpha pathway. Cell Prolif. 2012;45(3):239–48. doi: 10.1111/j.1365–2184.2012.00810.x.

[13] Sumida S, Ishihara K, Kishi M, Okuda K. Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant regions. Int J Oral Maxillofac Implants. 2002;17(5):696–702.

[14] Sumida S., Ishihara K., Kishi M., Okuda K. Transmission of periodontal disease-associated bacteria from teeth to osseointegrated implant regions. Int J Oral Maxillofac Implants. 2002;17(5):696–702.

[15] Heitz-Mayfield LJ, Lang NP. Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis. Periodontol 2000. 2010;53:167–81. doi: 10.1111/j.1600–0757.2010.00348.x.

[16] Heitz-Mayfield L.J., Lang N.P. Comparative biology of chronic and aggressive periodontitis vs. peri-implantitis. Periodontol 2000. 2010;53:167–81. doi: 10.1111/j.1600–0757.2010.00348.x.

[17] Kocar M, Seme K, Hren NI. Characterization of the normal bacterial flora in peri-implant sulci of partially and completely edentulous patients. Int J Oral Maxillofac Implants. 2010;25(4):690–8.

[18] Kocar M., Seme K., Hren N.I. Characterization of the normal bacterial flora in peri-implant sulci of partially and completely edentulous patients. Int J Oral Maxillofac Implants. 2010;25(4):690–8.

[19] Gudar'yan AA. The role of aerobic and anaerobic microflora in the development of dental mucositis and dental peri-implantitis. Vestnik problem biologii i meditsiny. 2014;1(2):132–6. (in Russian)

[20] Гударьян А.А. Роль аэробной и анаэробной микрофлоры в развитии дентального мукозита и дентального периимплантита. Вестник про-блем биологии и медицины. 2014;1(2):132–6.

[21] Nikolaeva EN, Tsarev VN, Panin AM, Chuvilkin VI, Khitarishvili MV, Tsareva TV. Detection of parodontopathogens (I and II orders) in patients with рeriimplantitis. Dental Forum. 2011;(4):10–2. (in Russian)

[22] Николаева Е.Н., Чувилкин В.И., Царев В.Н., Панин А.М., Хитаришвили М.В., Царева Т.В. Экспрессия пародонтопатогенных бактерий 1 и 2 порядка у пациентов с периимплантитами. Dental Forum. 2011;(4):10–2.

[23] Zorina OA, Venediktova VA, Prokop'ev VV, Amhadova MA. Study of impact periodontal protectoron peridontium state in health and in chronic periodontitis. Stomatologiya dlya vsekh. 2016;(3)34–9. (in Russian)

[24] Зорина О.А., Венедиктова В.А., Прокопьев В.В., Амхадова М.А. Изучение влияния пародонтопротекторов на состояние пародонта в норме и при хроническом пародонтите. Стоматология для всех. 2016;(3)34–9.

[25] Kit OI, Komarova EF, Kononenko VI, Pozdniyakova VV, Maksimov AYu, Demidova AA. Expression of transcription factors in tissues of oral mucosa cancer. Meditsinskiy vestnik Severnogo Kavkaza. 2016;11(4):517–20. (in Russian) doi: 10.14300/mnnc.2016.11122.

[26] Кит О.И., Комарова Е.Ф., Кононенко В.И., Позднякова В.В., Максимов А.Ю., Демидова А.А. Экспрессия транскрипционных факторов в тканях рака слизистой оболочки полости рта. Медицинский вестник Северного Кавказа. 2016;11(4):517–20. doi: 10.14300/mnnc.2016.11122.

[27] Han S, Xu W, Wang Z, Qi X, Wang Y, Niet Y, et al. Crosstalk between the HIF–1 and Toll–like receptor/nuclear factor–κB pathways in the oral squamous cell carcinoma microenvironment. Oncotarget. 2016;7(25):37773–89. doi: 10.18632/oncotarget.9329.

[28] Han S., Xu W., Wang Z., Qi X., Wang Y., Niet Y., et al. Crosstalk between the HIF–1 and Toll–like receptor/nuclear factor–κB pathways in the oral squamous cell carcinoma microenvironment. Oncotarget. 2016;7(25):37773–89. doi: 10.18632/oncotarget.9329.

[29] Wang J, Qi J, Zhao H, He S, Zhang Y, Wei S, Zhao F. Metagenomic sequencing reveals microbiota and its functional potential associated with per-iodontal disease. Sci Rep. 2013;3:1843. doi: 10.1038/srep01843.

[30] Wang J., Qi J., Zhao H., He S., Zhang Y., Wei S., Zhao F. Metagenomic sequencing reveals microbiota and its functional potential associated with periodontal disease. Sci Rep. 2013;3:1843. doi: 10.1038/srep01843.

[31] Roos-Jansåker AM, Renvert S, Egelberg J. Treatment of peri-implant infections: a literature review. J Clin Periodontol. 2003;30(6):467–85. doi: 10.1034/j.1600–051x.2003.00296.x.

[32] Roos-Jansåker A.M., Renvert S., Egelberg J. Treatment of peri-implant infections: a literature review. J Clin Periodontol. 2003;30(6):467–85. doi: 10.1034/j.1600–051x.2003.00296.x.

[33] Renvert S, Roos-Jansåker AM, Claffey N. Non-surgical treatment of peri-implant mucositis and peri-implantitis: a literature review. J Clin Perio-dontol. 2008;35(8 Suppl):305–15. doi: 10.1111/j.1600–051X.2008.01276.x.

[34] Renvert S., Roos-Jansåker A.M., Claffey N. Non-surgical treatment of peri-implant mucositis and peri-implantitis: a literature review. J Clin Perio-dontol. 2008;35(8 Suppl):305–15. doi: 10.1111/j.1600–051X.2008.01276.x.

[35] Máximo MB, de Mendonça AC, Renata Santos V, Figueiredo LC, Feres M, Duarte PM. Short-term clinical and microbiological evaluations of pe-ri-implant diseases before and after mechanical anti-infective therapies. Clin Oral Implants Res. 2009;20(1):99–108. doi: 10.1111/j.1600–0501.2008.01618.x.

[36] Máximo M.B., de Mendonça A.C., Renata Santos V., Figueiredo L.C., Feres M., Duarte P.M. Short-term clinical and microbiological evaluations of peri-implant diseases before and after mechanical anti-infective therapies. Clin Oral Implants Res. 2009;20(1):99–108. doi: 10.1111/j.1600–0501.2008.01618.x.

[37] Ghallab NA. Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: review of the current evidence. Arch Oral Biol. 2018;87:115–24. doi: 10.1016/j.archoralbio.2017.12.022.

[38] Ghallab N.A. Diagnostic potential and future directions of biomarkers in gingival crevicular fluid and saliva of periodontal diseases: review of the current evidence. Arch Oral Biol. 2018;87:115–24. doi: 10.1016/j.archoralbio.2017.12.022.

[39] de Araújo MF. Analysis of CD15, CD57 and HIF1α in biopsies of patients with peri-implantitis. Pathol. Res. Pract. 2017;213(9):1097–101. doi: 10.1016/j.prp.2017.07.020.

[40] de Araújo M.F. Analysis of CD15, CD57 and HIF1α in biopsies of patients with peri-implantitis. Pathol. Res. Pract. 2017;213(9):1097–101. doi: 10.1016/j.prp.2017.07.020.

[41] Lukyanova LD. Current issues of adaptation to hypoxia. Signal mechanisms and their role in system regulation. Patologicheskaya fiziologiya i eksperimental'naya terapiya. 2011;(1):3–19. (in Russian)

[42] Лукьянова Л.Д. Современные проблемы адаптации к гипоксии. Сигнальные механизмы и их роль в системной регуляции. Патологическая физиология и экспериментальная терапия. 2011;(1):3–19.

[43] Groeger SE, Meyle J. Epithelial barrier and oral bacterial infection. Periodontol 2000. 2015;69(1):46–67. doi: 10.1111/prd.12094.

[44] Groeger S.E., Meyle J. Epithelial barrier and oral bacterial infection. Periodontol 2000. 2015;69(1):46–67. doi: 10.1111/prd.12094.

[45] Zorina OA, Mustafina FK, Boriskina OA, Berkutova IS, Serebrja-ko-va OA. The efficacy of «PROF.GEORG BIRKMEIER OVER DENTAL GEL®» in the com-plex treatment of patients with chronic periodontitis. Stomatologiya dlya vsekh. 2018;(3):12–7. (in Russian)

[46] Зорина О.А., Мустафина Ф.К., Борискина О.А., Беркутова И.С., Серебрякова О.А. Эффективность применения «ПРОФ. ГЕОРГ БИРКМАЙЕР НАДХ ДЕНТАЛ ГЕЛЬ» в составе комплексного лечения у пациентов с хроническим пародонтитом. Стоматология для всех. 2018;(3):12–7.

[47] Wu D, Chen B, Cui F, He X, Wang W, Wang M. Hypoxia–induced microRNA–301b regulates apoptosis by targeting Bim in lung cancer. Cell Prolif. 2016;49(4):476–83. doi: 10.1111/cpr.12264.

[48] Wu D., Chen B., Cui F., He X., Wang W., Wang M. Hypoxia–induced microRNA–301b regulates apoptosis by targeting Bim in lung cancer. Cell Prolif. 2016;49(4):476–83. doi: 10.1111/cpr.12264.

[49] Alani A, Kelleher M, Bishop K. Peri-implantitis. Part 1: Scope of the problem. Br Dent J. 2014;217(6):281–7. doi: 10.1038/sj.bdj.2014.808.

[50] Alani A., Kelleher M., Bishop K. Peri-implantitis. Part 1: Scope of the problem. Br Dent J. 2014;217(6):281–7. doi: 10.1038/sj.bdj.2014.808.

[51] Zorina OA, Mustafina FK, Boriskina OA, Berkutova IS. Results of evaluation of the efficiency of phytopreparation ALFA Nectar in patients with chronic generalized periodontitis. Farmateka. 2016;(10):50–7. (in Russian)

[52] Зорина О.А., Мустафина Ф.К., Борискина О.А., Беркутова И.С. Результаты исследования эффективности применения фитопрепарата Alfa Nectar у пациентов с хроническим генерализованным пародонтитом. Фарматека. 2016;(10):50–7.

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