Prevalence of variants of the FAD-dependent amino oxidase gene in adolescents with internet addiction
K. V. Afonicheva
Cytokines and inflammation ›› 2023, Vol. 20 ›› Issue (3) : 9 -12.
Prevalence of variants of the FAD-dependent amino oxidase gene in adolescents with internet addiction
The aim of the research was to study the prevalence of rs1137070 MAOA polymorphism in Tuvan, Khakass and Russian adolescents, as well as the degree of their Internet addiction, assessed on the Chen scale. Materials and methods. The study included 559 adolescents of the Angara-Yenisei macroregion (Tuvinians, Khakas, Russians). The type of Internet addiction was assessed on the Chen scale, polymorphism was detected using real-time PCR. Results. It was revealed that the frequency of the TT rs1137070 genotype of the MAOA associated with low activity of the MAOA enzyme is significantly higher in Tuvan adolescents compared to Russians (31.1% vs. 21.2%, p=0.020). Pathological Internet addiction is more often observed among Khakas compared to Russian adolescents (26.4% vs. 15.5%, p=0.028). Thus, it is shown that the presence of a tendency to Internet addiction is potentially observed in carriers of the allele variant T rs1137070 MAOA, and Tuvans and Khakas, like other Asian populations, are more susceptible to the development of pathological dependencies, relative to Russians.
monoamine oxidase / polymorphism / Internet addiction / adolescents
| [1] |
Barry D. T., Steinberg M. A., Wu R., Potenza M. N. Differences in characteristics of Asian American and white problem gamblers calling a gambling helpline // CNS Spectr. 2009. Т. 14. № 2. P. 83-91. |
| [2] |
Clukay C., Dajani R., Hadfield K., Quinlan J., Panter-Brick C., Mulligan C. Association of MAOA genetic variants and resilience with psychosocial stress: A longitudinal study of Syrian refugees // PLoS ONE. 2019. Vol. 14. № 7. |
| [3] |
Ensembl - a genome browser for vertebrate genomes. Режим доступа: URL: https://www.ensembl.org/index.html (дата обращения: 14.04.2023). |
| [4] |
Luczak S.E., Khoddam R., Yu S., Wall T.L., Schwartz A., Sussman S. Review: Prevalence and co-occurrence of addictions in US ethnic/racial groups: Implications for genetic research // Am J Addict. 2017. Т. 26. № 5. P. 424-236. |
| [5] |
Mak K.K., Lai C.M., Ko C.H., Chou C., Kim D.I., Watanabe H., Ho R.C. Psychometric Properties of the Revised Chen Internet Addiction Scale (CIAS-R) in Chinese Adolescents // J. Abnorm. Child Psychol. 2014. Vol. 42. № 7. P. 1237-1245. |
| [6] |
McDermott R., Tingley D., Cowden J., Frazzetto G., Johnson D. Monoamine oxidase A gene (MAOA) predicts behavioral aggression following provocation // PNAS. 2009. Т. 106. № 7. P. 2118-2123. |
| [7] |
Narayanan Krishna S., Venkataramanan V., McNerney M. W. Problematic Internet use in adolescent psychosocial and physiological development. Oxford : Academic Press, 2023. – P. 245-258. |
| [8] |
Smolnikova M. V. Tereshchenko S.Yu. Pathogenetics of Internet addiction in adolescents // Siberian Medical Review. 2022. № 2 (134). P. 107. |
| [9] |
Sohrabi S. The criminal gene: the link between MAOA and aggression (review) // BMC Proc. 2015. Т. 9. № Suppl 1. P. A49. |
| [10] |
Young K. Internet addiction: The emergence of a new clinical disorder // Cyberpsychol Behav. 1998. Т. 1. Internet addiction. P. 237-244. |
| [11] |
Смольникова М. В., Терещенко С. Ю. Интернет-зависимость у подростков: поиск генетических ассоциаций // Мед. генетика. 2020. Т. 19. № 4. С. 46-48. Smolnikova M.V., Tereshchenko S.Yu. [Internet addiction in adolescents: the search for genetic associations] Medicinskaâ genetika (Moscow). 2020. Vol. 19. № 4. P. 46-48. Russian. |
Afonicheva K.V.
/
| 〈 |
|
〉 |
PDF
