Blood supply to the uterus and ovaries in healthy women and patients with ovarian insufficiency

Abstract

The aim of this study was to investigate the relation between ovarian blood flow, folliculogenesis and sex-steroid production during normal menstrual cycle and in women with ovarian failure. Ten healthy women and 40 patients with ovarian failure underwent hormonal assays (follicle-stimulating, luteinizing hormones, estradiol, progesterone, prolactine, testosterone) and ultrasound examination of the uterus and ovaries with color Doppler ultrasonography of the uterine and ovarian vessels on the 3 -5th, 11- 13th, 17- 19th and 21 -23rd days оf menstrual cycle. Intraovarian blood flow of the ovary carrying the predominant follicle in healthy women appeared more active than in conrdlateral ovary on the 3-5th days of the cycle. Inpatients with ovarian failure no difference was detected between the ovaries during the periods in question. Ovarian and uterine blood flow inpatients with the ovarian failure was less intensive comparingwith healthy women. Positive correlation between uterine blood flow and estradiol concentration in serum was revealed.

Keywords

blood supply to the ovaries / folliculogenesis / steroidogenesis

References

[1] Волкова О. В. Функциональная морфология женской репродуктивной системы. — М., 1983. - 325 с.

[2] Ковальский Г. Б., Китаев Э. М., Рыжавский Б. Я., Мельникова Л. М. Структурные основы генеративной и эндокринной функций яичников в норме и патологии. — СПб, 1996. - 204 с.

[3] НИКИТИНА. 14. Фолликуло- и оогенез при стимуляции овуляции // Акуш. и гин. — 1998. — №1. — С. 41-45.

[4] Побединский Н. М., Федорова Е. В. и др.Липман А. Д. Цветовое допплеровское картирование и допплерометрия артерий миометрия и эндометрия //Ультразв. диагн. — 2000. — №1.-С. 54-62.

[5] Стрижаков А. Н., Давыдов А. И. Клиническая трансвагинальная эхография. — М., 1997. - 321 с.

[6] Agrawal Р., Conway G. S., Sladkevicius Р, et al. Serum vascular endothelial growth factor (VEGF) in the normal menstrual cycle: association with changes in ovarian and uterine Doppler blood flow//Clin. Endocrinol. — 1999. — Vol. 50, № 1. -P. 101-106.

[7] Cacciatore B., SimbergN., TiitinenA., et al. Evidence of interplay between plasma endothelin-1 and 17 beta-estradiol in regulation of uterine blood flow and endometrial growth in infertile women // Fertil. Steril. — 1997. — Vol. 67, № 5. - P. 883-888.

[8] Cicinelli E., Ignarro L. J., Schonauer L. M., et al. Effects of short-term transdermal estradiol administration on plasma levels of nitric oxide in postmenopausal women // Fertil. Steril. - 1998. - Vol. 69, № 1.- P. 58-61.

[9] Coulam С. B., Goodman C., Pinehart J. S. Colour Doppler indices of follicular blood flow as predictors of pregnancy after in-vitro fertilization and embryo transfer// Hum. Peprod. — 1999. — Vol. 14, №8. - P. 1979-1982.

[10] Friden В. E., Wallin A., Brannstrom M. Phase-dependent influence of nonsteroidogenic cells on steroidogenesis and prostaglandin production by the human corpus luteum // Fertil.Steril. - 2000. - Vol. 73, № 2. - P. 359-365.

[11] Glock J. L., BrumstedJ. P. Color flow pulsed Doppler ultrasound in diagnosing luteal phase defect// Fertil. Steril. - 1995. - Vol. 64, № 3. - P. 500-504.

[12] HueyS., AbuhamadA., Barroso G., et al. Perifollicular blood flow Doppler indices, but not follicular pO2, pC02, or pH, predict oocyte developmental competence in vitro fertilization // Fertil. Steril. — 1999. - Vol. 72, №4. - P. 707-712.

[13] Kalogirou D., AntoniouG., BotsisD., etal. Transvaginal Doppler ultrasound with color flow imaging in the diagnosis of luteal phase defect (LPD) // Clin. Exp. Obstet. Gynecol.— 1997. - Vol. 24, № 2. - P. 95-97.

[14] KupesicS., KurjakA. The assessment of uterine and ovarian perfusion in infertile patients // Eur.J. Obstet. Gynecol. Peprod. Biol. — 1997. - Vol. 71, №2. - P. 151-154.

[15] KupesicS., KurjakA. Uterine and ovarian perfusion during the periovulatory period assessed by transvaginal color Doppler// Fertil.Steril. - 1993. - Vol. 60, № 3. - P. 439-443.

[16] LunenfeldE., Schwartz/., Meiznerl:, etal. Intraovarian blood flow during spontaneous and stimulated cycles // Human Peprod. — 1996. — Vol. 11, № 11. - P. 2481-2483.

[17] Sladkevicius P, Campbell S. Advanced ultrasound examination in the management of subfertility // Curr. Opin. Obstet. Gynecol. — 2000. — Vol. 12, №3. - P. 221-225.

[18] Steer С. V., Tan S. L, Mason B. A., et al. Midluteal-phase vaginal color Doppler assessment of uterine artery impedance in a subfertile population // Fertil. Steril. - 1994. - Vol. 61, № 1. - P. 53-58.

[19] SterzikK., AbtM., Grab D.,et al. Predicting the histologic dating of an endometrial biopsy specimen with the use of Doppler ultrasonography and hormone measurements in patients undergoing spontaneous ovulatory cycles // Fertil. Steril. — 2000. - Vol. 73, №1. -P. 94-98.

[20] Tan S. L., Zaidi J., Campbell S., et al. Blood flow changes in the ovarian and uterine arteries during the normal menstrual cycle //Am. J. Obstet. Gynecol. — 1996. — Vol. 175, № 3, Pt. 1. - P. 625-631.

[21] TinkanenH., KujansuuE., Laippala P. The association between hormone levels and vascular resistance in uterine and ovarian arteries in spontaneous menstrual cycles — a Doppler ultrasound study // Acta Obstet. Gynecol. Scand. — 1995. - Vol. 74, № 4. - P. 297-301.

[22] Tinkanen H. The role of vascularisation of the corpus luteum in the short luteal phase studied by Doppler ultrasound //Acta Obstet. Gynecol. Scand. — 1994. — Vol. 73, №4. - P. 321-323.

[23] Yokota A., Nakai A., OyaA., et al. Changes in uterine and ovarian arterial impedance during the periovulatory period in conception and nonconception cycles // J. Obstet. Gynaecol. Res. - 2000. — Vol. 26, № 6. - P. 435-440.

[24] Zaidi J., Collins W., Campbell S.,et al. Blood flow changes in the intraovarian arteries during the periovulatory period: relationship to the time of day// Ultrasound Obstet. Gynecol. — 1996. - Vol. 7, № 2. - P. 135-140

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