Markers of bone remodeling in patients with surgical menopause undergoing hormone replacement therapy with Divigel

Abstract

Twenty women with surgical menopause, 40-50 years of age, received hormonal replacement therapy with transdermic preparation Divigel during 24 months. On the background of therapy with Divigel we witnessed normalization of indeces of osteal remodeling—considerable decrease pyridinoline and deoxypyridinoline, and elevation of alkaline phosphatase. Mineral density of bone tissue in the group of patients with surgical menopause waslowerin comparison with control (p<0,01). Divigeltumedto exertprotective influence on the bone tissue inpatients with osteoporosis irrespective о f duration о f surgical menopause by the beginning of therapy.

Keywords

menopause / hormone therapy / Divigel

References

[1] Краснопольский В. И., Рубченко Т. И. Хирургическая менопауза // Пробл. репрод. — 1998. — №5.— С. 76-80.

[2] Сметник В. П. Постменопаузальный остеопороз: принципы заместительной гормонотерапии // Остеопороз и остеопатии. — 1998. — № 2. — С. 21-24.

[3] Black D., Duncan A., Robins S. Р. Quantitative analysis of the pyridinoline crosslinks of collagen in urine using ion-paired reversed- phase H PLC //Anal. Biochem. — 1988. - Vol. 169. - P. 197-203.

[4] Delmas P. D. Biochemical markers of bone turnover// Acta Orthop. Scand.— 1995. - Vol. 66, Suppl. 266. - P. 176-182.

[5] EyreD. R., Oguechi H. The pyridinium crosslinks of skeletal collagens: their measurement, properties and a proposed pathway of formation // Biochem. Biophys. Res. Commun. — 1980. — Vol. 92. — P. 403-410.

[6] Hashimoto K., Nozaki M., Inoue Y., etal. The chronological change of vertebral loss following oophorectomy using dual energy X-ray absorbtiometry: the correlation with specific markers of bone metabolism //Maturitas. — 1995. — Vol. 22. — P. 185-192.

[7] Hreshchyshyn M., Hopkins A., Zylstra S., etal. Effects of natural menopause, hysterectomy and on lumbar spine and femoral neck bone densities // Obstet. Gynecol. — 1988. - Vol. 72, № 8. - P. 631-638.

[8] Kress В. C. Bone alkaline phosphatase in normal and disease processes // Schmidt-Gayk H. E., Blind E., Roth H.-J. (eds.). Calcium regulating hormones and markers of bone metabolism: measurement and interpretation. — Heidelberg. — Clin. Lab. Publications. — 1997. — P. 171- 181.

[9] Price С. P. Multiple forms of human serum alkaline phosphatase: Detection and quantitation //Ann. Clin. Biochem. — 1993. — Vol. 30. — P. 355-372.

[10] Price С. P, Thompson P. W. The role of biochemical tests in the screening and monitoring of osteoporosis //Ann. Clin. Biochem. — 1995. - Vol. 32. - P. 244-260.

[11] Robins S. P, Black D., Paterson C. R., Reid D. M., Duncan A., Seibel M. J. Evaluation of urinary hydroxypyridinium crosslink measurements as resorption markers in metabolic bone diseases // Eur. J. Clin. Invest. - 1991. - Vol. 21.- P. 310-315.

[12] Sands R., Studd W., Jones J., Alaghband-Zade J. Comparison of the biochemical effects of testosteron and estrogen on bone markers in surgically menopausal women // Gynecol. Endocrinol. — 2000. — № 14.— P. 382—387.

[13] Van StraalenJ. P, Sanders E., Prummel M. F., Sanders G. T. B. Bone-alkaline phosphatase as indicator of bone formation // Clin. Chim. Acta. -1991.- Vol. 201.- P. 27-34.

[14] Withold W., Schulte U., Reinauer H. Method for determination of bone alkaline phosphatase activity: analytical performance and clinical usefulness in patients with metabolic and malignant bone diseases//Clin. Chern. - 1996. - Vol. 42, № 2. - P. 210-217

RIGHTS & PERMISSIONS

Eсо-Vector