The role of antiphospholipid antibodies on the pathogenesis of habitual pregnancy loss
O. N. Arzhanova , T. N. Shliakhtenko , S. А. Selkov , T. А. Pluzhnikova , О. V. Tishkevitch , А. V. Fedorenko , E. A. Shapovalova
Journal of obstetrics and women's diseases ›› 2002, Vol. 51 ›› Issue (2) : 18 -22.
The role of antiphospholipid antibodies on the pathogenesis of habitual pregnancy loss
Clinical and anamnesis analysis as well as analysis of the course and outcome of the present pregnancy was performed on 595 patients with complicated obstetrical and gynecological history (COGH) — habitual pregnancy loss, infertility, genital chronic processes. Control groupconsisted of 5O healthy women. Immunofluorescent analysis was used to reved antiphospholipid antibodies on blood plasma. Antiphospholipid antibodies were found in 42% of COGH women. No antiphospholipid antibodies were seen in the control group. In all patients of the studied groupthe course of pregnancy was accompanied with signs of threatened abortion, gestosis. 29% (p< O, O1) patients had preterm labor and spontaneous abortion occurred in 18% (p< O, O1) of cases. Perinatal mortality was 9, 8%±4, 16.
the role of antiphospholipid antibodies / AFA / pathogenesis of miscarriage
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