The role of antiphospholipid antibodies on the pathogenesis of habitual pregnancy loss

O. N. Arzhanova; T. N. Shliakhtenko; S. А. Selkov; T. А. Pluzhnikova; О. V. Tishkevitch; А. V. Fedorenko; E. A. Shapovalova

doi:10.17816/JOWD90372

Journal of obstetrics and women's diseases ›› 2002, Vol. 51 ›› Issue (2) : 18 -22. DOI: 10.17816/JOWD90372

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The role of antiphospholipid antibodies on the pathogenesis of habitual pregnancy loss

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Abstract

Clinical and anamnesis analysis as well as analysis of the course and outcome of the present pregnancy was performed on 595 patients with complicated obstetrical and gynecological history (COGH) — habitual pregnancy loss, infertility, genital chronic processes. Control groupconsisted of 5O healthy women. Immunofluorescent analysis was used to reved antiphospholipid antibodies on blood plasma. Antiphospholipid antibodies were found in 42% of COGH women. No antiphospholipid antibodies were seen in the control group. In all patients of the studied groupthe course of pregnancy was accompanied with signs of threatened abortion, gestosis. 29% (p< O, O1) patients had preterm labor and spontaneous abortion occurred in 18% (p< O, O1) of cases. Perinatal mortality was 9, 8%±4, 16.

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the role of antiphospholipid antibodies / AFA / pathogenesis of miscarriage

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O. N. Arzhanova, T. N. Shliakhtenko, S. А. Selkov, T. А. Pluzhnikova, О. V. Tishkevitch, А. V. Fedorenko, E. A. Shapovalova. The role of antiphospholipid antibodies on the pathogenesis of habitual pregnancy loss. Journal of obstetrics and women's diseases, 2002, 51(2): 18-22 DOI:10.17816/JOWD90372

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