Role of atrial natriuretic peptide (ANP) in feto-placental and maternal circulation

Abstract

ANPwas measured in maternal cubital vein (M), umbilical vein (UV) and artery (UA) in 39 women at term delivery (23 vaginal, 16 caesarean): 15 - normal pregnancy; 24 pregnancies were complicated by placental insufficiency, 14 - by preeclampsia, 10 - by diabetes mellitus. Blood gases and pH in UA, UV were measured.

M, UA, UV ANPat caesarean section was similar to that in vaginal delivery (p>0,05). In normal and complicated pregnancies, UA ANPwas significantly higher than ANPin M and UV. In pregnancies complicated by diabetes mellitus, UV ANPwas higher than ANPin UA (21, 93 fmol/l and 13, 03 fmol/l). In pregnancies complicated by acute placental insufficiency, UV ANPwas significantly lower than that in UA in normal pregnancy (p<0,001). There is positive correlation between ANPconcentration and pH in UV.

Fetus is capable of ANPproduction. ANPmay be synthesized in the placenta.

Fetal hypoxia appears to be a potent stimulus for elevating of ANPplasma concentration.

Keywords

natriuretic peptide / mother-placenta-fetus / hemodynamic system / atrial natriuretic polypeptide / fetoplacental and maternal circulation

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