Molecular neuroimmunoendocrinology: role and significance in the regulation of reproductive function

Abstract

The review paper is devoted to analysis of current molecular biological investigations, which testify on the molecular chemical unity of the signaling mechanisms into three classical regulatory systems-nervous, endocrine and immune ones. This biological general phenomenon allows to create a new special field of biomedicine-neuroimmunoendocrinology, which studies the structural-functional basis and molecular unity of neuroimmunoendocrine regulation of homeostasis in norm and pathology. The special attention pays on the presence of nervous, endocrine and immune cells in the reproductive system, which produce hormonal substances (regulatory peptides, biogenic amines, and related molecules) in situ inside endometrium, placenta, mammary glands. The role of these molecules in the mechanisms of reproduction is discussed.

Keywords

neuroimmunoendocrinology / regulatory peptides / reproductive function

References

[1] Райхлин Н.Т., Кветной И.М., Осадчук М.А. APUD- система (общепатологические и онкологические аспекты). - Обнинск, 1993, 212 с.

[2] Сережин Б.С., Ломакина И.И. Апудоциты и апудомы предстательной железы, молочных желез и матки // Арх. патол. - 1986. - Т.48, №12. - С. 72-77.

[3] Шейнина Л.И., Кутивадзе Д.А., Сулава Т.А. и др. Иммуногистохимия апудоцитов молочной железы при диспластических и опухолевых процессах / Регуляторные пептиды и биогенные амины. Радиобиологические и онкорадиологические аспекты / Под. ред. А.Ф. Цыба, И.М. Кветного. Обнинск, 1992. - С. 129-132.

[4] Abraham S., Indrasingh I., Vettivel S. et al. Gross morphology and ultrastructure of dendritic cells in the normal human decidua // Clin. Anat. - 2000. - Vol. 13, № 3. - P. 177-80.

[5] Bagot C.N., Troy P.J., Taylor H.S. Alteration of maternal Hoxa 10 expression by in vivo gene transfection affects implantation // Gene Ther. — 2000. - N 7. - P. 1378-1384.

[6] Daftary G.S., Taylor H.S. Molecular markers of implantation: clinical implications // Curr. Opin. Obstet. Gynecol. - 2001. - Vol. 13. - P. 269-274.

[7] Dickson R.B., Lippman M.E. Growth factors in breast cancer // Endocrine Reviews. - 1995. - Vol.16, N 5. - P. 559-589.

[8] Dilioglou S., Cruse J.M., Lewis R.E. Costimulatory function of umbilical cord blood CD14(+) and CD34(+) derived dendritic cells // Exp. Mol. Pathol. — 2003. - Vol. 75, N 1 - P. 18-33.

[9] Dines K.C., Powell H.C. Mast cell interactions with the nervous system: relationshipto mechanisms of disease // J. Neuropathol. Exper. Neurol. - 1997. - Vol. 56. - P. 627-640.

[10] Giudice L.C. Multifaceted roles for IGFBP-1 in human endometrium during implantation and pregnancy // Ann. N.Y. Acad. Sci. - 1997. - Vol. 828. - P. 146-156.

[11] Illera M.J., Cullinan E., Guy Y. et al. Blockade of the alpha(v)beta(3) integrin adversely affects implantation in the mouse // Biol. Reprod. - 2000. — Vol. 62. - P. 1285-1290.

[12] Inagami T., Naruse M., Hoover R. Endothelium as an endocrine organ // Ann. Rev. Physiol. - 1995. - Vol. 57. - P. 171-189.

[13] Hill J.A., Choi B.C. Maternal immunological aspects of pregnancy success and failure // J. Reprod. Fertil. Suppl. - 2000. - Vol. 55. - P. 91-97.

[14] Hopkins S.J., Rothwell N.J. Cytokines and nervous system I: expression and recognition // Trends Neurosci. - 1995. - N 18. - P. 83-88.

[15] Hsieh-Li H.M., Witte D.P., Weinstein M. et al. Hoxa 11 structure, extensive antisense transcription, and function in male and female fertility // Development. - 1995. - Vol. 121. -P. 1373-1385.

[16] Kammerer U., Schoppet M., McLellan A. et al. Human decidua contains potent immunostimulatory CD83(+) dendritic cells // Am. J. Pathol. - 2000. - Vol. 157, N 1. - P. 159-69.

[17] Kvetnoy I.M. Extrapineal melatonin: location and role within diffuse neuroendocrine system // Histochem. J. - 1999. - Vol. 31. - P. 1-12.

[18] Kvetnoy I.M., Hernandez-Yago J., Hernandez J.M. et al. Diffuse neuroendocrine system and mitochondrial diseases: molecular and cellular bases of pathogenesis, new approaches to diagnosis and therapy // Neuroendocrinol. Lett. - 2000. - N 21. - P. 83-99.

[19] Kvetnoy I.M., Reiter R.J., Khavinson V.H. Claude Bernard was right: hormones may be produced by "non-endocrine" cells // Neuroendocrinol. Lett. - 2000. — N 21. - P. 173-174.

[20] Merrill J.E., Jonakait G.M. Interactions of the nervous and immune system in development, normal brain homeostasis and disease // FASEB J. - 1995. - N 9. - P. 611-618.

[21] Montes M., Aleman P., Garcia-Tortosa C. et al. Cultured human decidual stromal cells express antigens associated with hematopoietic cells //J. Reprod. Immunol. - 1996. - Vol. 30, N1.-P. 53-66.

[22] Mummidi S., Catano G., Lam L. et al. Extensive repertoire of membrane-bound and soluble dendritic cell-specific ICAM-3-grabbing nonintegrin 1 (DC-SIGN1) and DC-SIGN2 isoforms. Inter-individual variation in expression of DC-SIGN transcripts // J. Biol. Chem. - 2001. - Vol. 276, N 35. - P. 33196-33212.

[23] Pearse A.G.E. The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept // J. Histochem. Cytochem. - 1969. - Vol. 17. - P. 303-313.

[24] Polak J. M., Bloom S.R. Immunocytohemistry of diffuse neuroendocrine system / Immunocytohemistry: modern methods and applications / Ed. J.M.Polak, Svan Noorden. Bristol: John Wright & Sons Ltd, 1986. - P. 328-348.

[25] Psychoyos A. Uterine receptivity for nidation // Ann. N.Y. Acad. Sci. - 1986. - Vol. 476. - P. 36-42.

[26] Salzet M. Immune cells express endocrine markers // Neuroendocrinol. Lett. - 2002. - N 3. - P. 8-9.

[27] Satokata I., Benson G., Maas R. Sexually dimorphic sterility phenotypes in Hoxa 10-deficient mice // Nature. - 1995. - Vol. 374. - P. 460-463.

[28] Soilleux E.J., Barten R., Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13 // J. Immunol. - 2000. - Vol. 165, N 6. - P. 2937-2942.

[29] Sternberg E.M. Interactions between the immune and neuroendocrine systems / Progress in brain research / Ed. E.A.Mayer, C.B.Saper. - Vol. 122. - Elsevier Science BV, 2000. -P. 328-348.

[30] Szabolcs P., Park K.D., Reese M. et al. Absolute values of dendritic cell subsets in bone marrow, cord blood, and peripheral blood enumerated by a novel method // Stem. Cells. - 2003. - Vol. 21, N 3. - P. 296-303.

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