Cytokine production by peripheral blood lymphocytes in patients with ovarian epithelial tumors

R. V. Pavlov; V. A. Aksenenko; A. Yu. Krivoruchko; N. A. Pavlenko

doi:10.17816/JOWD89004

Journal of obstetrics and women's diseases ›› 2001, Vol. 50 ›› Issue (1) : 37 -40. DOI: 10.17816/JOWD89004

Scientific activity

research-article

Cytokine production by peripheral blood lymphocytes in patients with ovarian epithelial tumors

Author information +

History +

PDF

Abstract

In presence of autoserum, production of IL1b, IL2, IL4, IL6 and TNFa by peripheral blood lymphocytes of 30 patients with epithelial tumors of ovaries and 50 patients with epithelial ovarian cancer of I-IV stages was investigated. The data received enable to ascertain the increase of mononuclear activity during ovarian tumor progression, increase of T-helpers of the second type activity, along with the reduction of T-helpers of the first type activity in peripheral blood of patients, and abnormalities of IL6-dependent mechanism of control of ILIb and TNFa production by peripheral blood lymphocytes of patients with ovarian cancer.

Keywords

peripheral blood lymphocyte cytokines / increased activity of T-helpers

Cite this article

Download citation ▾

R. V. Pavlov, V. A. Aksenenko, A. Yu. Krivoruchko, N. A. Pavlenko. Cytokine production by peripheral blood lymphocytes in patients with ovarian epithelial tumors. Journal of obstetrics and women's diseases, 2001, 50(1): 37-40 DOI:10.17816/JOWD89004

登录浏览全文

4963

注册一个新账户忘记密码

References

Publishing order | Descend order by publishing year | Descend order by cited within

[1]	Бережная Н.М., Ковальчук Б.В., Осипова Е. В. Влияние продуктов культивирования опухолевых клеток различного гистогенеза на функциональную активность лимфоцитов крови человека в зависимости от чувствительности опухолевых биоптатов к ИЛ-2//

[2]	Экспериментальная онкология. - 1993. - Том 10, № 3. - С. 46-50.

[3]	Возианов А.Ф., Бутенко А.К., Зак К. П. Цитокины. Биологические и противоопухолевые свойства. - Киев: Наукова думка, 1998. - 317 с.

[4]	Володько Н.А., Билынский Б.Т., Кадар О. В. Оценка активности фактора некроза опухоли (ФИО) у онкологических больных // Вопросы онкологии. - 1994. - Том 40, №4-6. - С. 181-185.

[5]	Грачева Л.А. Цитокины в онкогематологии. - М.: Алтус, 1996. - 122 с.

[6]	Яковлева Н.В., Аксенова Н.Я., Ковальчук Л. В., Павлюк А. С. Иммунорегуляторная роль моноцитов при злокачественных опухолях яичников // Тезисы доклада I Съезда иммунологов России, Новосибирск, 23-25 июня, 1992. - Новосибирск, 1992. - С. 580.

[7]	Boyum A. Isolation of mononuclear cells and granulocytes from human blood // Scand. J. Clin. Lab. Invest. - 1968. - Vo 1.21, N3. - P. 77-82.

[8]	Еlsasser-Beile U., von Kleist S., Gallati H., Pfleiderer A. Evaluation of cytokine levels in whole cell cultures of patients with gynaecological tumors as diagnostic parameters // Anticancer Res. - 1991. - Vol.11, N3. - P. 1093 - 1095.

[9]	Schondorf T, Engel H., Lindemann C., Kolhagen H., von Rucker A.A., Mallmann P. Cellular characteristics of peripheral blood lymphocytes and tumour-infiltrating lymphocytes in patients with gynaecological tumours // Cancer Immunol. Immunother. - 1997. - Vol.44, N2. - P. 88-96.

[10]	Schondorf T, Engel H., Kurbacher C.M., Brenne U., Kolhagen H., Gbhring U.J., Scharl A., Mallmann P. Immunologic features of tumor-infiltrating lymphocytes and peripheral blood lymphocytes in ovarian cancer patients //J. Soc. Gynecol. Investig. - 1998. - Vol. 5, N2. - P. 102 - 107.