Modern conceptions for cervical cancer prevention

Abstract

Human papillomavirus (HPV) is found to be the central risk factor for cervical cytologic abnormalities and cancer. The purpose of the study was to estimate the sensitivity and prognostic value of polymerase chain reaction (PCR) and Hybrid Capture 2 (HC 2) for HPV DNA detection, to determine the rate of cytologic abnormalities and attending infections in HPV-infected women. 729 women were investigated for HPVDNA detection. HC 2 had sensitivity compared with PCR, hut it had advantages in viral load detection. The rate of HPV DNA detection was up to 30% in women with cervical pathology, among them in21%o of cases cytologic abnormality was revealed. The peak detection of HPV was between ages 20 and 30. The same ages were characterized by the peak of cervical pathology. 31%> of HPV-infected women had coexisted bacterial infections (chlamydiosis, mycoplasmosis or ureaplasmosis), 35% - Herpes simplex virus infection. HPV-detection can improve the timely revealing of cervical cytologic abnormalities. The bacteriology and virology screening with corresponding therapy must he also included in investigation complex of HPV-infected women.

Keywords

cervical cancer / early diagnosis / detection / polymerase chain reaction / 2nd generation molecular hybridization

References

[1] Cox J.T., Lorinez А.Т., Schiffmann M.H et. al. //Amer. J. of Obst. And Gyn. 1995. Vol. 172. P. 946-954.

[2] Cuzik J., Szarewsky A., Terry G. et. al.//Lancet. 1995. Vol. 345. P. 1533- 1536.

[3] Hildesheim A,. Schiffman M.H., Gravitt P. et. al. //J. of Inf. Dis. 1994. Vol. 169. P 235-240.

[4] Koutsky L.A., Holmes K.K., Critchlow C.W. et. al.//N. Engl. J. of Medicine. 1992. Vol. 327. P. 1272- 1278.

[5] Sherman M.E., Schiffman M.H., Lorincz A.T. et. al. //Amer. J. of Clin. Path. 1994. Vol. 101. P. 182-187.

[6] Slater D.N., Milner PC., Radley H./ /J. of Clin. Path. 1994. Vol.47. P.27-28.

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